The high production of melons in Indonesia is affected by non-optimal post-harvest handling and the accelerated loss of quality due to its abundant water content, which reduce its economic value. The Sky Rocket variety is Indonesia's most widely grown type of melon. The post-harvest handling of melon that has not been implemented is the production of jam. The correct recipe must be determined to produce melon spread, or jam, with good characteristics. This study aims to determine the effects of the sucrose and acidifier on the physicochemical and sensory characteristics of the melon spread and to find the combination of treatments that produce the melon spread with the best physicochemical and sensory characteristics. This study used experimental methods and factorial randomized block design. The observed factors were the concentration of sucrose, 40%, 50% and 60%, and the type of acidifier, citric acid, lime and pineapple. Experiments were performed three times; thus, there were 27 experimental units. The variables observed included water content, acidity (pH), total dissolved solids and vitamin C content, as well as sensory variables such as colour, spreadability, texture, melon aroma, sweet taste and preference. The use of different concentrations of sucrose affected the water content, total dissolved solids, and sensory variables of the melon spread. The type of acidifier affected the physicochemical and sensory variables of the melon spread, except for the total dissolved solids. The interaction between the sucrose and the acidifier only affected the sensory variables. The best treatment combinations were treatment with 50% sucrose and pineapple with a water content of 31.49%, pH 6.90, TPT 71.00°Bx, vitamin C of 114.40 mg/100 g, colour 3.55 (bright green), spreadability 4.05, texture 3.12, melon aroma 3.00, sweet taste 4.23 and preference 3.43.