Background: Optimism has different effects on patients with chronic rheumatic disease. Gout is an increasingly prevalent disorder around the world, while the compliance to urate lowering therapy (ULT) of gout patients is poor. The objective of this study was to assess the optimism of gout patients. Contributors to optimism and poor compliance were also explored.Methods: A total of 530 gout patients, 174 ankylosing spondylitis (AS) patients, 60 rheumatoid arthritis (RA) patients and 324 healthy volunteers were included. Optimism, anxiety, and depression were measured by the life orientation test-revised (LOT-R), self-rating anxiety scale (SAS) and self-rating depression scale (SDS). Demographic and disease characteristic were recorded, including education, residence, disease duration, etc. Severity of pain in the involved joints was assessed by the visual analog scale (VAS). Concentration of serum uric acid (SUA) was collected at baseline and the last examination within the follow-up. Compliance to ULT was investigated by the medication possession ratio (MPR) in 3 months. The contributors to optimism and poor compliance were detected by the multivariate and binary logistic regression analysis.Results: The LOT-R score of gout patients was higher than AS and RA patients, but there was no statistical difference between gout patients and healthy controls. The SAS and SDS score of gout patients were lower than AS and RA patients, while the SDS score of gout patients was higher than healthy controls. The mean disease duration and VAS score were 5.0 (2.0-7.3) years and 2.0 (0.0-4.0). Percentage of gout patients with an MPR<0.8 was 55.1%. Insufficient education contributed to optimism in gout patients. Insufficient education, living in countryside, higher concentration of SUA and higher LOT-R score led to poor compliance to ULT.Conclusion. The optimism of gout patients is greater compared with AS and RA patients. The compliance to ULT is poor, which ascribes to optimism. Furthermore, the optimism of gout patients may attribute to insufficient education.