The Effect of Drug Molecules on the Phase Transition of Lipids

Interactions of Phenothiazines with Lipid Bilayer and their Role in Multidrug Resistance Reversal

“…Presumably due to its common usage in psychiatry the most extensively studied phenothiazine derivative was chlorpromazine. The effect of chlorpromazine on the phase transition properties of DPPC was studied by Cater et al [34]. Using differential scanning calorimetry they found that CPZ induced the concentrationdependent decrease of phase transition temperature accompanied by the broadening of the transition peaks.…”

Interaction of Chlorpromazine with Phospholipid Membranes: A Monolayer and a Microelectrophoresis Approach

“…Chlorpromazine (Cpz) is a phenotiazine with neuroleptic activity, showing a large capacity to interact with biological membranes and sometimes be used as a local anesthetic. [1][2][3][4][5][6][7][8][9] Cpz has an amino group and because of its pK a value, [10][11][12] exists essentially in its charged form at physiological pH (with a small amount of neutral form). In some earlier works, the local anesthetic-lipid interaction has been interpreted in terms of a "Langmuir" adsorption 9,[13][14][15][16] and, in others, in terms of a partition coefficient.…”

Magnetic resonance studies on the interaction of antidepressants with lipid model membranes

“…In a publication, Cater et al [8] reported mainly calorimetric evidence (DSC) of modifications in the physical state of the lipid produced by a large series of compounds, assuming in the case of DMI some modification to be responsible of the strong shift in the transition temperature (T,). With the parameters obtained here it is possible to make a measure of the tilt and spread angles of the chains, and the differences in tilting caused by DMI.…”