The Effect of Drugs in the Production of Agranulocytosis With Particular Reference to Amidopyrine Hypersensitivity 1

Dameshek, William; Colmes, Abraham

doi:10.1172/jci100760

Cited by 64 publications

(13 citation statements)

References 11 publications

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“…In the prototype of this, aminophenazone-dependent serum leucoagglutinins were found during active aminophenazone-induced agranulocytosis (Dameshek & Colmes 1936;Magis et al 1962;Moeschlin & Wagner 1952;Squier & Madison 1935). Similar drug-dependent leucoagglutination was described in connection with agranulocytosis induced by phenylbutazone (Pretty et al 1965), chlorpropamide (Levitt 1987), sulphonamides (Evans & Ford 1958) and mercurial diuretics (Koszewski & Hubbard 1956).…”

Section: Discussionmentioning

confidence: 94%

On the Possible Mechanisms and Predictability of Clozapine†-Induced Agranulocytosis

et al. 1992

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Studies were conducted on serum removed from 15 patients before, during, and after, clozapine-induced agranulocytosis. Cytotoxic studies were compared with samples taken from patients during treatment with clozapine who did not develop agranulocytosis or treatment controls (TC); additional controls consisted of allogeneic (NC) and autogeneic serum from apparently normal people. The effect of serum on measurable functions of polymorphonuclear neutrophils (PMNs) taken from normal people was tested. Procedures under study included suppression of postphagocytosis-induced 14C02-indicated respiratory burst, as well as ejection of try pan blue by test PMNs. PMNs exposed to active agranulocytosis serum plus complement displayed diminished 14C02 emission during phagocytosis or failed to eject trypan blue. PMNs exposed to serum of TC and NC continued to function normally as regards 14C02 emission and trypan blue ejection. Five patients studied before the development of agranulocytosis showed suppressed PMN function, which increased to peak value during agranulocytosis and then disappeared within 40 days of recovery. Similar suppression of colony forming units of granulocytes and macrophages (CFU-GM) was found whenever agranulocytosis serum was included in the marrow culture. The cytotoxic material required complement for its full expression, was not dialysable, was neutralised by anti-IgM serum, and was absorbed by test PMNs. Furthermore, solutions of clozapine or 5 of its metabolites offered no similar suppression of PMN function in vitro after incubation in an aqueous medium or with normal serum. These observations favour development of an immunogenic clone in sensitive people during active treatment with clozapine, which eventually leads to precipitous depletion of PMNs and their precursors. The early appearance of this suppressive substance may offer an early warning for development of agranulocytosis.

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Section: Discussionmentioning

confidence: 94%

On the Possible Mechanisms and Predictability of Clozapine†-Induced Agranulocytosis

et al. 1992

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“…However, direct evidence for such a mechanism is often limited. One of the first drugs to be associated with a high incidence (1%) of agranulocytosis was aminopyrine (138,139). There was a rapid drop in neutrophils on reexposure to the drug, suggesting peripheral destruction of neutrophils.…”

Section: Role Of Cellular Disposition Inmentioning

confidence: 99%

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

Park

Pirmohamed

Kitteringham

1998

Chem. Res. Toxicol.

251

126

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“…A reasonable explanation can be offered by the observations of Plum (1937) and Dameshek and Colmes (1936).…”

Section: Amidopyrine Causes Agranulocytosis In Great Britainmentioning

confidence: 80%

Agranulocytosis Caused by Amidopyrine

Discombe¹

1952

BMJ

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The Effect of Drugs in the Production of Agranulocytosis With Particular Reference to Amidopyrine Hypersensitivity 1

Cited by 64 publications

References 11 publications

On the Possible Mechanisms and Predictability of Clozapine†-Induced Agranulocytosis

On the Possible Mechanisms and Predictability of Clozapine†-Induced Agranulocytosis

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

Agranulocytosis Caused by Amidopyrine

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