The Effect of Early Postnatal Nutrition on Human T Cell Leukemia Virus Type 1 Mother-to-Child Transmission: A Systematic Review and Meta-Analysis

Miyazawa, Tokuo; Murase, Masahiko; Sakurai, Motoichiro; Itabashi, Kazuo; Yonemoto, Naohiro

doi:10.3390/v13050819

Cited by 7 publications

(16 citation statements)

References 23 publications

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“…2-4) [113]. The results suggest that STBF ≤ 3 months does not increase the risk of MTCT compared to ExFF, but the risk of MTCT may increase by approximately threefold if the duration of STBF is up to 6 months.…”

Section: Systematic Review and Meta-analysismentioning

confidence: 77%

“…Finally, 11 articles (i.e., 10 previous studies and our prospective cohort study [94]) were included in the meta-analysis. Six articles on the effect of STBF ≤ 3 months [94,[103][104][105][106][107], five articles on STBF ≤ 6 months [104,106,[108][109][110], and three articles on FTBMF [94,111,112] were included for the systematic review and meta-analysis [113]. The pooled relative risks of STBF ≤ 3 months, STBF ≤ 6 months, and FTBMF compared with ExFF were 0.72 (95% CI: 0.30-1.77; p = 0.48), 2.91 (95% CI: 1.69-5.03; p = 0.0001), and 1.14 (95% CI: 0.20-6.50; p = 0.88), respectively (Figures 2-4) [113].…”

Section: Systematic Review and Meta-analysismentioning

confidence: 99%

“…Six articles on the effect of STBF ≤ 3 months [94,[103][104][105][106][107], five articles on STBF ≤ 6 months [104,106,[108][109][110], and three articles on FTBMF [94,111,112] were included for the systematic review and meta-analysis [113]. The pooled relative risks of STBF ≤ 3 months, STBF ≤ 6 months, and FTBMF compared with ExFF were 0.72 (95% CI: 0.30-1.77; p = 0.48), 2.91 (95% CI: 1.69-5.03; p = 0.0001), and 1.14 (95% CI: 0.20-6.50; p = 0.88), respectively (Figures 2-4) [113]. The results suggest that STBF ≤ 3 months does not increase the risk of MTCT compared to ExFF, but the risk of MTCT may increase by approximately threefold if the duration of STBF is up to 6 months.…”

Section: Systematic Review and Meta-analysismentioning

confidence: 99%

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Mother-to-Child Transmission of Human T-Cell Leukemia Virus Type 1: Mechanisms and Nutritional Strategies for Prevention

Itabashi

Miyazawa

2021

Cancers

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Approximately 95% of mother-to-child transmission (MTCT) of human T-cell leukemia virus type-1 (HTLV-1) is derived from prolonged breastfeeding, which is a major cause of adult T-cell leukemia (ATL). Exclusive formula feeding (ExFF) is therefore generally used to prevent MTCT. A recent cohort study revealed that 55% of pregnant carriers chose short-term breastfeeding for ≤ 3 months in Japan. Our meta-analysis showed that there was no significant increase in the risk of MTCT when breastfeeding was carried out for ≤ 3 months compared with ExFF (pooled relative risk (RR), 0.72; 95% confidence interval (CI), 0.30–1.77), but there was an almost threefold increase in risk when breastfeeding was carried out for up to 6 months (pooled RR, 2.91; 95% CI, 1.69–5.03). Thus, short-term breastfeeding for ≤ 3 months may be useful in preventing MTCT. Breastmilk is the best nutritional source for infants, and any approach to minimizing MTCT by avoiding or limiting breastfeeding must be balanced against the impact on the child’s health and mother–child bonding. To minimize the need for nutritional interventions, it is necessary to identify factors that predispose children born to carrier mothers to MTCT and thereby predict MTCT development with a high degree of accuracy.

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Section: Systematic Review and Meta-analysismentioning

confidence: 77%

Section: Systematic Review and Meta-analysismentioning

confidence: 99%

Section: Systematic Review and Meta-analysismentioning

confidence: 99%

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Mother-to-Child Transmission of Human T-Cell Leukemia Virus Type 1: Mechanisms and Nutritional Strategies for Prevention

Itabashi

Miyazawa

2021

Cancers

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“…co-infection; and access to safe, affordable formula feeding. A recent meta-analysis showed that short-term breastfeeding was not associated with a significant increase in the transmission of HTLV-1 [ 20 ]. However, the data were mainly restricted to Japan and may not be representative in other settings.…”

Section: Discussionmentioning

confidence: 99%

Anti-HTLV-1/2 IgG Antibodies in the Breastmilk of Seropositive Mothers

et al. 2021

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Background: HTLV-1/2 mother-to-child transmission (MTCT) is an important route for the maintenance of HTLV-1/2 within populations and disproportionally contributes to the burden of HTLV-1-associated diseases. Avoidance of breastfeeding is the safest recommendation to prevent MTCT. Due to the benefits of breastfeeding, alternative methods that would allow seropositive mothers to breastfeed their babies are needed. There is limited knowledge about HTLV-1/2 infection and breastmilk. Methods: Paired blood and milk samples collected from HTLV-1/2 seropositive mothers were tested for HTLV-1 proviral load (PVL) quantification and for the detection of anti-HTLV-1/2 IgG. Results: All breastmilk samples had detectable anti-HTLV-1/2 IgG. HTLV-1/2 proviral DNA was detected in all samples except for one. HTLV-1 PVL and IgG binding ratio (BR) was similar in milk and plasma. However, antibody titer was significantly higher in blood (Median (95%CI): Milk:128 (32–512); Plasma:131,584 (16,000–131,584), p < 0.05). There was a strong correlation between HTLV-1 PVL, anti-HTLV-1/2 IgG BR, and titer when comparing milk and blood. PVL did not correlate with antibody BR nor titer in blood or milk. Conclusions: Anti-HTLV-1/2 IgG are present in milk in the same proportion as blood but in lower quantity. PVL in milk correlates with blood.

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“…In this context, Itabashi et al conducted a prospective multicenter cohort study involving HTLV-1 carrier pregnant women and their infants as part of the Health, Labor, and Welfare Science Research Program in Japan to determine the rate of MTCT by ExFF, STBF, and FTBMF [ 56 ]. Miyazawa et al reported findings through a systematic review that integrated the results of the cohort study and previous studies [ 103 ].…”

Section: Strategies To Prevent Htlv-1 Mtctmentioning

confidence: 99%

How Can We Prevent Mother-to-Child Transmission of HTLV-1?

Itabashi¹,

Miyazawa

Uchimaru

2023

IJMS

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The perception of human T-cell leukemia virus type 1 (HTlV-1) infection as a “silent disease” has recently given way to concern that its presence may be having a variety of effects. HTLV-1 is known to cause adult T-cell leukemia (ATL), an aggressive cancer of peripheral CD4 T cells; however, it is also responsible for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Most patients develop ATL as a result of HTLV-1 mother-to-child transmission. The primary route of mother-to-child transmission is through the mother’s milk. In the absence of effective drug therapy, total artificial nutrition such as exclusive formula feeding is a reliable means of preventing mother-to-child transmission after birth, except for a small percentage of prenatal infections. A recent study found that the rate of mother-to-child transmission with short-term breastfeeding (within 90 days) did not exceed that of total artificial nutrition. Because these preventive measures are in exchange for the benefits of breastfeeding, clinical applications of antiretroviral drugs and immunotherapy with vaccines and neutralizing antibodies are urgently needed.

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The Effect of Early Postnatal Nutrition on Human T Cell Leukemia Virus Type 1 Mother-to-Child Transmission: A Systematic Review and Meta-Analysis

Cited by 7 publications

References 23 publications

Mother-to-Child Transmission of Human T-Cell Leukemia Virus Type 1: Mechanisms and Nutritional Strategies for Prevention

Mother-to-Child Transmission of Human T-Cell Leukemia Virus Type 1: Mechanisms and Nutritional Strategies for Prevention

Anti-HTLV-1/2 IgG Antibodies in the Breastmilk of Seropositive Mothers

How Can We Prevent Mother-to-Child Transmission of HTLV-1?

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