The effect of early prednisolone treatment on the generalization rate in ocular myasthenia gravis

Abstract

Our results agree well with previous studies on this issue. Taken together, published data indicate risk ratios for generalization of below 0.32 under corticosteroid treatment in comparison to untreated patients.

Prognosis of Ocular Myasthenia Gravis

“…Sommer et al 6 Previous studies have shown overall conversion rates of OMG to GMG of 50% to 64%. 2,4,12,13 Our series of OMG patients showed a much lower overall conversion rate of 20.9%, consistent with more recent retrospective studies reporting overall conversion rates ranging from 23% to 31%, 6,8,14,15 and this low conversion rate was observed in subjects with or without immunosuppressant therapy. Prior studies have emphasized the possible effect of immunotherapy on conversion rates.…”

Geographical Distribution of Myasthenia Gravis in Northern Europe - Results from a Population-Based Study from Two Countries

“…We believe that the difference is not due to bias, since the distribution of ocular and bulbar versus the generalized symptoms EOMG was similar in both countries. One may speculate whether this difference derives from treatment differences between the two cohorts, such as early treatment with corticosteroids in purely ocular-manifested MG, thereby preventing conversion to a generalized disease [35] . On the other hand, variable frequencies for ocular MG are described around Europe (13-52%) [3,25] .…”

Presented with Uncommon Complaints in a Case of Pediatric Ocular Myasthenia Gravis

“…Although most of the retrospective studies have indicated that the reduced rates of generalization in patients with OMG who were administered early corticosteroid treatment, it has not been confirmed with a randomized prospective controlled study, yet. 5,13,14 MG is an autoimmune, multifactorial, clinically broad spectrum of disease which is seen more frequent in females and related to the neuromuscular junction. It is commonly easy to diagnose if suspected, however it is also easy to be misdiagnosed.…”