The effect of efflux pump inhibitors on in vitro and in vivo efficacy of solid lipid nanoparticles containing SN38

Nasirizadeh, Samira; Jaafari, Mahmoud Reza; Iranshahi, Mehrdad; Golmohammadzadeh, Shiva; Mahmoudi, Asma; Ansari, Legha; Mosallaei, Navid; Malaekeh‐Nikouei, Bizhan

doi:10.1016/j.jddst.2020.101969

Cited by 10 publications

(5 citation statements)

References 50 publications

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“…Figure 6(B) shows the uptake of SN38-NPs is 2.89-fold higher than free SN38 and 2.07-fold higher than SN38-NPs without HA after 6 h. Higher drug concentrations in Caco-2 cells in comparison with C26 cells was due to more P-gp in Caco-2 cells and more efficacy of efflux inhibitors such as PEGylated chitosan [51].…”

Section: Cellular Uptake Of Fluorescent Sn38-npsmentioning

confidence: 98%

Synthesis of novel polymeric nanoparticles (methoxy-polyethylene glycol-chitosan/hyaluronic acid) containing 7-ethyl-10-hydroxycamptothecin for colon cancer therapy: in vitro, ex vivo and in vivo investigation

Sharifi

Jahangiri

Ebrahimnejad

2021

Artificial Cells, Nanomedicine, and Biotechnology

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Section: Cellular Uptake Of Fluorescent Sn38-npsmentioning

confidence: 98%

Synthesis of novel polymeric nanoparticles (methoxy-polyethylene glycol-chitosan/hyaluronic acid) containing 7-ethyl-10-hydroxycamptothecin for colon cancer therapy: in vitro, ex vivo and in vivo investigation

Sharifi

Jahangiri

Ebrahimnejad

2021

Artificial Cells, Nanomedicine, and Biotechnology

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“…(2) SLNs also improve drug bioavailability. Samira et al [ 41 ] designed SN38-loaded SLNs and evaluated the drug uptake efficiency in vitro by Caco-2 and C26 cell lines. It was observed that SN38-loaded SLNs were significantly internalized in C26 and Caco-2 cell lines at 2 and 4 h compared to free SN38.…”

Section: Nano-delivery Systems Loaded With Antitumor Active Ingredien...mentioning

confidence: 99%

Smart Targeted Delivery Systems for Enhancing Antitumor Therapy of Active Ingredients in Traditional Chinese Medicine

Kang

Wang

et al. 2023

Molecules

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As a therapeutic tool inherited for thousands of years, traditional Chinese medicine (TCM) exhibits superiority in tumor therapy. The antitumor active components of TCM not only have multi-target treatment modes but can also synergistically interfere with tumor growth compared to traditional chemotherapeutics. However, most antitumor active components of TCM have the characteristics of poor solubility, high toxicity, and side effects, which are often limited in clinical application. In recent years, delivering the antitumor active components of TCM by nanosystems has been a promising field. The advantages of nano-delivery systems include improved water solubility, targeting efficiency, enhanced stability in vivo, and controlled release drugs, which can achieve higher drug-delivery efficiency and bioavailability. According to the method of drug loading on nanocarriers, nano-delivery systems can be categorized into two types, including physically encapsulated nanoplatforms and chemically coupled drug-delivery platforms. In this review, two nano-delivery approaches are considered, namely physical encapsulation and chemical coupling, both commonly used to deliver antitumor active components of TCM, and we summarized the advantages and limitations of different types of nano-delivery systems. Meanwhile, the clinical applications and potential toxicity of nano-delivery systems and the future development and challenges of these nano-delivery systems are also discussed, aiming to lay the foundation for the development and practical application of nano-delivery systems of TCM in clinical settings.

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“…Nano-formulations are commonly developed for a wide variety of applications in the biomedical area such as specific analyte detection [ [69] , [70] , [71] ], specific disorder diagnosis [ 72 ], targeted delivery and co-delivery of therapeutic agents [ 73 ], efflux pump circumvention [ 74 , 75 ] as well as preventing embedded drugs' enzymatic degradation, adjusted drug release, improving pharmacokinetics, and enhancing the wound-healing efficacy [ 76 , 77 ]. Accordingly, nanotechnology is the vanguard for the improvement of the solubility and bioavailability of aqueous insoluble drugs/compounds.…”

Section: Nanotechnology For Delivery Of Narmentioning

confidence: 99%

Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease

Mehranfard,

Ghasemi,

Rajabian

et al. 2023

Heliyon

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The effect of efflux pump inhibitors on in vitro and in vivo efficacy of solid lipid nanoparticles containing SN38

Cited by 10 publications

References 50 publications

Synthesis of novel polymeric nanoparticles (methoxy-polyethylene glycol-chitosan/hyaluronic acid) containing 7-ethyl-10-hydroxycamptothecin for colon cancer therapy: in vitro, ex vivo and in vivo investigation

Synthesis of novel polymeric nanoparticles (methoxy-polyethylene glycol-chitosan/hyaluronic acid) containing 7-ethyl-10-hydroxycamptothecin for colon cancer therapy: in vitro, ex vivo and in vivo investigation

Smart Targeted Delivery Systems for Enhancing Antitumor Therapy of Active Ingredients in Traditional Chinese Medicine

Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease

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