The effect of Ehlers-Danlos syndromes on TMJ function and craniofacial pain

Mitakides, John

doi:10.1080/08869634.2018.1435092

Cited by 9 publications

(6 citation statements)

References 14 publications

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“…Previous studies have shown that patients with EDS have a significant higher prevalence of CMD symptoms compared to a control group [22]. In addition to affecting the temporomandibular joint, patients with EDS often show an increased mouth opening (for 69.5% of our cohort the maximal incisal edge was above 40mm), having a higher risk of sudden meniscal and/or condylar jaw dislocation, which can lead to inflammation of the affected regions [23].…”

Section: Discussionmentioning

confidence: 70%

“…To help those patients who suffer from CMD and to increase their OHRQoL, CMD-specific physiotherapy is recommended to counteract damage to the temporomandibular joint (TMJ) [23]. This therapy can involve both changes in body posture and changes in everyday life, such as chewing habits or stress management techniques.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 46 participants were included in the study with 91.3% being female (see Table 2), i.e., four participants were male and 42 were female. The median age (interquartile range (IQR)) of the participants was 39.5 (23) years. At the time of diagnosis, the median age (IQR) was 34 (25) years.…”

Section: Age and Diagnosis Periodmentioning

confidence: 99%

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Correlation between Oral Health-Related Quality of Life and Objectively Measured Oral Health in People with Ehlers–Danlos Syndromes

Oelerich

Kleinheinz

Reißmann

et al. 2020

IJERPH

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It is a well-known fact that people with Ehlers–Danlos syndromes (EDS) report a worse oral health-related quality of life (OHRQoL) than the general population. The aim of this study was to examine whether there is a correlation between the subjective OHRQoL and the objectively measured oral health in people with EDS. To determine the subjective OHRQoL, the German version of the 14-item Oral Health Impact Profile (OHIP-14) questionnaire was used. Furthermore, all participants in the study were clinically examined, and the measured parameters were recorded using the Physical Oral Health Index (PhOX). Altogether, records of 46 participants were collected. The median (interquartile range (IQR)) of the OHIP-14 was 17 (23) points and the median of the PhOX was 73 (16) points. However, a statistically significant correlation could not be demonstrated (r = −0.240, p = 0.108). In the observed cohort, for participants who reported having pain often or very often, the OHIP score (median = 24, IQR = 18, p < 0.01) was higher than the score of the group given by participants who never or intermittently experienced pain (median = 8, IQR = 18). In conclusion, patients with EDS showed a reduced OHRQoL, although it was not possible to observe an association between the subjective OHRQoL and the objective oral health. However, participants who often or very often suffer from pain in their tooth, mouth, and jaw areas showed a reduced OHRQoL.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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Correlation between Oral Health-Related Quality of Life and Objectively Measured Oral Health in People with Ehlers–Danlos Syndromes

Oelerich

Kleinheinz

Reißmann

et al. 2020

IJERPH

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“…137 Anatomical abnormalities in orofacial structures have been identified in hEDS populations, such as the absence of lingual and inferior labial frenula. 141,142 Subluxations and dislocation of the temporomandibular joint, along with temporomandibular disorders (TMD) are a significant occurrence in hEDS patients, [143][144][145][146] which may be attributed to vertebral posture and cervical functions of the head and neck. 147 As craniocervical instability has been noted among hEDS populations, muscle spasms bordering the anterior, posterior, and suboccipital triangle muscles may result in the overuse and spasm of mastication muscles, sequentially resulting in subluxation of the temporomandibular joint.…”

Section: Oral and Mandibular Manifestationsmentioning

confidence: 99%

Hypermobile Ehlers‐Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understood causes

Gensemer

Burks

Kautz

et al. 2020

Developmental Dynamics

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The Ehlers-Danlos syndromes (EDS) are a group of heritable, connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. There is phenotypic and genetic variation among the 13 subtypes. The initial genetic findings on EDS were related to alterations in fibrillar collagen, but the elucidation of the molecular basis of many of the subtypes revealed several genes not involved in collagen biosynthesis or structure. However, the genetic basis of the hypermobile type of EDS (hEDS) is still unknown. hEDS is the most common type of EDS and involves generalized joint hypermobility, musculoskeletal manifestations, and mild skin involvement along with the presence of several comorbid conditions. Variability in the spectrum and severity of symptoms and progression of patient phenotype likely depend on age, gender, lifestyle, and expression domains of the EDS genes during development and postnatal life. In this review, we summarize the current molecular, genetic, epidemiologic, and pathogenetic findings related to EDS with a focus on the hypermobile type.

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“…Based on the existing literature, TMD among EDS has been assessed by a few studies and without considering the heterogeneity of EDS. 4,7–9 However, the classification of EDS was changed considerably in 2017, and apart from hEDS, 10 other subtypes are considered as rare diseases. In the past, the different subtypes have often been studied collectively.…”

Section: Introductionmentioning

confidence: 99%

Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review

Oelerich,

Daume,

Yekkalam

et al. 2024

J Int Med Res

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This narrative review aims to demonstrate and summarize the complex relationship between Ehlers-Danlos syndromes (EDS) and temporomandibular disorders (TMD) by reviewing the results of observational studies and case reports. EDS are a set of hereditary connective tissue disorders, where generalized joint hypermobility (GJH), especially in the hypermobile subtype (hEDS), is a key symptom. Mutations have been identified in genes that impact the production or assembly of collagen for all subtypes except hEDS. While the correlation between GJH and TMD has been analysed in various studies, fewer studies have examined TMD in patients with EDS, with most showing an increased prevalence of TMD. In case–control studies, an elevated prevalence of myalgia, arthralgia and disc-related disorders was found in individuals with EDS. Various therapeutic interventions have been reported within the literature in the form of case reports and observational studies, but there are no long-term clinical trials with results on the efficacy of different therapeutic approaches to date. This review demonstrates the high prevalence of different TMDs in different subtypes of EDS, but also shows that little is known about the success of treatment thus far. Further clinical research is necessary to provide adequate guidance on targeted treatment.

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The effect of Ehlers-Danlos syndromes on TMJ function and craniofacial pain

Cited by 9 publications

References 14 publications

Correlation between Oral Health-Related Quality of Life and Objectively Measured Oral Health in People with Ehlers–Danlos Syndromes

Correlation between Oral Health-Related Quality of Life and Objectively Measured Oral Health in People with Ehlers–Danlos Syndromes

Hypermobile Ehlers‐Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understood causes

Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review

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