2007
DOI: 10.1111/j.1528-1167.2006.00948.x
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The Effect of Electrical Stimulation and Lesioning of the Anterior Thalamic Nucleus on Kainic Acid–Induced Focal Cortical Seizure Status in Rats

Abstract: The electrical stimulation and lesioning of ANT suppressed focal cortical clinical seizures induced by KA injection. Additionally, an analysis of cerebral metabolic changes indicated that these procedures might suppress the function as amplifier and synchronizer of seizure activity.

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Cited by 86 publications
(44 citation statements)
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“…Successful establishment of the KA-TLE model was confirmed by video recordings of spontaneous epileptic seizures in KA-treated monkeys. Our results showed that the mean number of total seizures was significantly lower in the ATN-stimulation group compared with the shamstimulation group, indicating that ATN-stimulation was effective in seizure reduction,which is consistent with previous studies (Fisher et al, 2010;Hamani et al, 2008;Hodaie et al, 2002;Jou et al, 2013;Kerrigan et al, 2004;Lim et al, 2007;Mirski et al, 1997;Takebayashi et al, 2007). Moreover, our results revealed that the changes in the amino acid levels in the ATN-stimulation group were significantly different from those changes in the sham-stimulation group.…”
Section: Discussionsupporting
confidence: 93%
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“…Successful establishment of the KA-TLE model was confirmed by video recordings of spontaneous epileptic seizures in KA-treated monkeys. Our results showed that the mean number of total seizures was significantly lower in the ATN-stimulation group compared with the shamstimulation group, indicating that ATN-stimulation was effective in seizure reduction,which is consistent with previous studies (Fisher et al, 2010;Hamani et al, 2008;Hodaie et al, 2002;Jou et al, 2013;Kerrigan et al, 2004;Lim et al, 2007;Mirski et al, 1997;Takebayashi et al, 2007). Moreover, our results revealed that the changes in the amino acid levels in the ATN-stimulation group were significantly different from those changes in the sham-stimulation group.…”
Section: Discussionsupporting
confidence: 93%
“…It is known that electrical and pharmacological stimulation of certain brain regions can promote or inhibit the release of neurotransmitters, causing various effects in the downstream neuronal compartment (Chang et al, 2009;Takebayashi et al, 2007). An excessive release of neurotransmitters can sometimes induce neurodegenerative alterations, as observed in animal studies (Salazar and Tapia, 2012).…”
Section: Discussionmentioning
confidence: 97%
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“…Two other circuits are believed to be involved in the propagation of seizures: the corticothalamic circuit and the mammillary circuit. The corticothalamic circuit involves propagation of seizure activity from the motor cortex to the caudate, putamen, the globus pallidus and the thalamus,8 and unilateral, repeated stimulation of this circuit can result in continual partial seizures 42. The mammillary circuit also involves the ANT, from which seizure activity is propagated to the mammillary bodies to the brainstem 8…”
Section: Discussionmentioning
confidence: 99%
“…The rationale for the AN target comes from the early work of Mirski et al [11][12][13] who demonstrated a reduction in drug-induced seizures in a rodent model with interruption, or high-fre-quency stimulation, of the Papez circuit. Subsequent preclinical studies [14][15][16][17] have confirmed that the AN is a key node in this pathway that can influence seizure initiation and propagation. Electrophysiologic mapping of this circuit has also been conducted in patients undergoing investigational AN DBS.…”
Section: Introductionmentioning
confidence: 99%