The effect of electrical stimulation on reinnervation of rat muscle: contractile properties and endplate morphometry

Eberstein, Arthur; Pachter, Bruce R.

doi:10.1016/0006-8993(86)91166-2

Cited by 25 publications

(17 citation statements)

References 11 publications

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“…Artificially maintaining muscle activity during the period of denervation/paralysis may improve neuromuscular rehabilitation. Electrostimulation of denervated muscle, passive exercise, and locomotion training have been shown to be effective strategies to retard muscle atrophy and to improve contractile responses after reinnervation 8, 34–37. It was suggested that induced activity that mimics physiological motion would produce better preservation/recovery of muscle functional properties than conventional electrical stimulation 8, 31.…”

Section: Discussionmentioning

confidence: 99%

“…Less is known about the effects of passive motion of the denervated limbs. Some studies have shown that passive exercise of the denervated muscle before reinnervation preserves the structure of the end‐plates and enhances reinnervation 35. In contrast, continuous passive motion of the hindlimb after tibial nerve section did not influence nerve regeneration, although this treatment was only performed during the first 14 days after injury 51.…”

Section: Discussionmentioning

confidence: 99%

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Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat

2011

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat

2011

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“…forma, é comum, na prática clínica da fisioterapia, o emprego da eletroestimulação com o objetivo de minimizar a atrofia muscular e favorecer boa recuperação funcional da lesão nervosa periférica (22)(23)(24)(25).…”

Section: Resultsunclassified

Efeito da eletroestimulação no músculo desnervado de animais: revisão sistemática

Cavalcante¹,

Silva²,

Montenegro

et al. 2012

Fisioter. mov.

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INTRODUÇÃO: A recuperação funcional após a lesão nervosa periférica está relacionada a fatores intrínsecos e extrínsecos ao sistema nervoso periférico, tais como a gravidade da lesão e a condição dos órgãos-alvo. A atrofia constitui uma das principais alterações do músculo após a lesão nervosa e, uma vez instalada, atua como barreira ao crescimento axonal durante a reinervação muscular. O uso da eletroestimulação é rotineiro no campo da fisioterapia e tem o objetivo de minimizar ou impedir a atrofia muscular e, assim, favorecer a recuperação da lesão nervosa periférica. OBJETIVO: Avaliar os efeitos da eletroestimulação sobre as características tróficas do músculo desnervado. MÉTODOS: Artigos publicados entre 1990 e 2010 e indexados aos bancos de dados da PUBMED foram selecionados utilizando os seguintes descritores: "muscle denervation AND electric stimulation" e "muscular atrophy AND electric stimulation". Foram considerados como critério de inclusão os estudos experimentais em animais (ratos) que utilizassem a lesão nervosa periférica como modelo de desnervação e que avaliassem o efeito da eletroestimulação muscular sobre a área de secção transversa e/ou a massa muscular de músculos desnervados. RESULTADOS: Nove artigos foram selecionados para a revisão. CONCLUSÕES: O efeito da eletroestimulação está diretamente relacionado à característica do protocolo de intervenção, que, quando aplicado de maneira adequada, apresenta o efeito de retardar e, em alguns casos, impedir a atrofia do músculo desnervado.

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“…Some of the physiological benefits of using electrical stimulation for this application include (1) maintaining the normal sarcomere pattern and preventing degeneration and atrophy of muscle fibers and acetylcholine receptors in the neuromuscular junctions, [47][48][49][50][51][52][53][54][55] (2) maintaining the structural and functional integrity of the denervated muscles that in turn enhances its functional recovery after re-innervation, [56][57][58][59] (3) up-regulation of the production of neurotrophic factors by the denervated skeletal muscle.…”

Section: Electrical Stimulationmentioning

confidence: 99%

Multi‐channel orbicularis oculi stimulation to restore eye‐blink function in facial paralysis

et al. 2001

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Facial paralysis due to facial nerve injury results in the loss of function of the muscles of the hemiface. The most serious complication in extreme cases is the loss of vision. In this study, we compared the effectiveness of single- and multiple-channel electrical stimulation to restore a complete and cosmetically acceptable eye blink. We established bilateral orbicularis oculi muscle (OOM) paralysis in eight dogs; the OOM of one side was directly stimulated using single-channel electrical stimulation and the opposite side was stimulated using multi-channel electrical stimulation. The changes in the palpebral fissure and complete palpebral closure were measured. The difference in current intensities between the multi-channel and single-channel simulation groups was significant, while only multi-channel stimulation produced complete eyelid closure. The latest electronic stimulation circuitry with high-quality implantable electrodes will make it possible to regulate precisely OOM contractions and thus generate complete and cosmetically acceptable eye-blink motion in patients with facial paralysis.

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The effect of electrical stimulation on reinnervation of rat muscle: contractile properties and endplate morphometry

Cited by 25 publications

References 11 publications

Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat

Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat

Efeito da eletroestimulação no músculo desnervado de animais: revisão sistemática

Multi‐channel orbicularis oculi stimulation to restore eye‐blink function in facial paralysis

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