The effect of electro-acupuncture on pro-oxidant antioxidant balance values in overweight and obese subjects: a randomized controlled trial study

Mazidi, Mohsen; Parizad, P. Abbasi; Arazi, Hamid; Zhao, Baixiao; Rahsepar, Amir Ali; Tavallaie, Shima; Parizadeh, Seyed Mostafa; Rezaie, Peyman; Safariyan, Mohammad; Nematy, Mohsen; Mohammadi, Maryam; Darbandi, Mahsa; Darbandi, Sara; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.

doi:10.1515/jcim-2015-0081

Cited by 14 publications

(14 citation statements)

References 15 publications

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“…Generally, improvements of diet and lifestyle are recommended; however, the effect on weight loss is often unsatisfactory. A large body of clinical and experimental evidence shows that acupuncture is effective for the treatment of obesity, and that acupuncture treatment is accompanied by a reduction in obesity-related com-plications, such as hyperlipidemia[ 21 , 22 ]. Indeed, in this study, the AG mice were observed to have lower body weight and less abdominal adiposity with an improved blood lipid status, in comparison to NG mice.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture improved lipid metabolism by regulating intestinal absorption in mice

Guo

Meng

et al. 2020

WJG

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BACKGROUND Non-alcoholic fatty liver disease (NAFLD), in which abnormal lipid metabolism plays an important role in disease progression, has become a pandemic. Abnormal lipid metabolism, for example an increased fat intake, has been thought to be an initial factor leading to NAFLD. The small intestine is the main site of dietary lipid absorption. A number of clinical trials have shown that acupuncture has positive effects in the regulation of lipid metabolism, which is closely associated with the progression of NAFLD. We therefore hypothesized that, acupuncture can improve the conditions of NAFLD by regulating intestinal absorption of lipid. AIM To study the role of acupuncture treatment in the improvement of metabolic syndrome secondary to NAFLD by mouse model. METHODS 8-wk-old male C57BL/6J mice were fed a methionine- and choline-deficient diet for 3 wk. Then, all mice were separated randomly into acupoints group (AG) or non-acupoints group (NG) with high fat diet feeding. Needling treatment was performed at Zu san li, Guan yuan and Yong quan acupoints as acupuncture treatment to AG mice while non-acupoints place to NG mice. Finally, mice were anesthetized with an injection of ketamine-medetomidine and euthanized by exsanguination. RESULTS An apparent improvement of obesity was found in AG mice after acupuncture treatment. In AG mice, the body weight was much lower (22.6 ± 1.2 g vs 28.1 ± 1.0 g, P < 0.005) in comparison to NG mice. The length of small intestine in AG mice was significantly shorter (26.7 ± 2.3 cm vs 32.7 ± 2.7 cm, P < 0.005). A large amount of chyme was observed in the lumen of the AG small intestine. The expression of microsomal triglyceride transfer protein, apolipoprotein B and apolipoprotein C2 was downregulated. Triacylglycerols (TGs), total cholesterol and nonesterified fatty acid (NEFA) levels of the small intestinal tissue were significantly higher in AG mice, but the serum TGs and NEFA levels were reduced in AG mice. CONCLUSION These results indicate that acupuncture at Zu san li, Guan yuan and Yong quan suppressed lipid absorption by downregulating the expression of apolipoproteins in the small intestine.

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Section: Discussionmentioning

confidence: 99%

Acupuncture improved lipid metabolism by regulating intestinal absorption in mice

Guo

Meng

et al. 2020

WJG

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“…In obese subjects, acupuncture treatment significantly decreased serum pro-oxidant antioxidant balance (PAB) values, which has been shown to be positively correlated to body weight and also increased in obese patients [34]. Eight acupuncture points on the abdomen, including Tianshu (ST-25) bilateral, Weidao (GB-28) bilateral, Zhongwan (REN-12), Shuifen (REN-9), Guanyuan (REN-4), Sanyinjiao (SP-6), and additional points including Quchi (LI-11) and Fenlong (ST-40) for excess mood (patients with higher energy) and Qihai (REN-6) and Yinlingqau (SP-9) for deficiency mood (patients with lower energy) on both lower legs, were selected.…”

Section: Evidence From Clinical Studiesmentioning

confidence: 99%

Mechanisms of Acupuncture Therapy for Simple Obesity: An Evidence-Based Review of Clinical and Animal Studies on Simple Obesity

Wang

Huang

Wei

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Simple obesity is a worldwide epidemic associated with rapidly growing morbidity and mortality which imposes an enormous burden on individual and public health. As a part of Traditional Chinese Medicine (TCM), acupuncture has shown the positive efficacy in the management of simple obesity. In this article, we comprehensively review the clinical and animal studies that demonstrated the potential mechanisms of acupuncture treatment for simple obesity. Clinical studies suggested that acupuncture regulates endocrine system, promotes digestion, attenuates oxidative stress, and modulates relevant molecules of metabolism in patients of simple obesity. Evidence from laboratory indicated that acupuncture regulates lipid metabolism, modulates inflammatory responses, and promotes white adipose tissue browning. Acupuncture also suppresses appetite through regulating appetite regulatory hormones and the downstream signaling pathway. The evidence from clinical and animal studies indicates that acupuncture induces multifaceted regulation through complex mechanisms and moreover a single factor may not be enough to explain the beneficial effects against simple obesity.

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“…In particular, there is experimental evidence that acupuncture not only reduces body weight, but also increases adiponectin and decreases leptin in obese rats (Peplow, 2015). This is supported by the results of clinical trials which show that acupuncture can reduce not only body weight and fat content, but also obesity-related complications, such as serum pro-oxidant antioxidant imbalance, dyslipidemia, and inflammation (Mazidi et al, 2017). Another interesting experimental finding is that electro-acupuncture (EA) increases cold endurance in the Stat5NKO mouse model of obesity (Fu et al, 2017).…”

Section: Introductionmentioning

confidence: 81%

Role of Neuro-Immune Cross-Talk in the Anti-obesity Effect of Electro-Acupuncture

Gong

et al. 2020

Front. Neurosci.

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There is evidence to show that electro-acupuncture (EA) has a promotive effect on both lipolysis and thermogenesis, and that these mechanisms underlie the anti-obesity effect of EA. The sympathetic nervous system (SNS) is known to play a role in thermogenesis. Additionally, obesity is characterized by a chronic low-grade inflammatory state. Based on these findings, the aim of the present study is to investigate the potential neuro-immune mechanisms underlying the therapeutic effect of EA in obesity. In the experiment, we used a high fat diet (HFD) rats model to study the effect of EA in reducing body weight. EA increases the activity of sympathetic nerves in inguinal white adipose tissue (iWAT), especially in the HFD group. Compared to HFD rats, EA can decrease sympathetic associated macrophage (SAM) and the level of norepinephrine transporter protein (Slc6a2). The relative uncoupling protein 1 expression shows EA increases thermogenesis in iWAT, and increases β3 receptors. Interestingly, injecting β antagonist in iWAT increases Slc6a2 protein levels. Additionally, the SNS-macrophage cross-talk response to EA showed in iWAT but not in epididymis white adipose tissue. The results of the present study indicate that EA exerts its anti-obesity effect via three mechanisms: (1) inhibition of SAMs and the norepinephrine transporter protein SlC6a2, (2) promoting SNS activity and thermogenesis, and (3) regulating immunologic balance.

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The effect of electro-acupuncture on pro-oxidant antioxidant balance values in overweight and obese subjects: a randomized controlled trial study

Cited by 14 publications

References 15 publications

Acupuncture improved lipid metabolism by regulating intestinal absorption in mice

Acupuncture improved lipid metabolism by regulating intestinal absorption in mice

Mechanisms of Acupuncture Therapy for Simple Obesity: An Evidence-Based Review of Clinical and Animal Studies on Simple Obesity

Role of Neuro-Immune Cross-Talk in the Anti-obesity Effect of Electro-Acupuncture

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