1990
DOI: 10.1097/00132582-199007000-00023
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The Effect of Elevated Blood Glucose on the Electroencephalogram and Cerebral Metabolism During Short-Term Brain Ischemia in Fetal Sheep

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Cited by 3 publications
(4 citation statements)
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“…For example, hyperglycemia, which occurred in the dexamethasone-treated rats during hypoxia,' tends to exacerbate ischemic damage in adults but may be beneficial in young animals. [22][23][24][25] As observed in the present study, dexamethasone also inhibits somatic growth, and studies by others suggest that growth retardation may either reduce brain damage caused by hypoxia-ischemia in neonatal rats26 or increase damage in growth-retarded newborn piglets.27 Irrespective of its overall physiological effect, dexamethasone likely binds to glucocorticoid receptors within the cell, and the hormone receptor complex then interacts with specific regulating DNA elements. This results in either positive or negative control of gene expression.…”
Section: Methodsmentioning
confidence: 60%
“…For example, hyperglycemia, which occurred in the dexamethasone-treated rats during hypoxia,' tends to exacerbate ischemic damage in adults but may be beneficial in young animals. [22][23][24][25] As observed in the present study, dexamethasone also inhibits somatic growth, and studies by others suggest that growth retardation may either reduce brain damage caused by hypoxia-ischemia in neonatal rats26 or increase damage in growth-retarded newborn piglets.27 Irrespective of its overall physiological effect, dexamethasone likely binds to glucocorticoid receptors within the cell, and the hormone receptor complex then interacts with specific regulating DNA elements. This results in either positive or negative control of gene expression.…”
Section: Methodsmentioning
confidence: 60%
“…27,35 Dexamethasone and glucose treatment attenuated the rate of rise in cortical impedance and increased EEG activity during asphyxia, consistent with previous findings at term gestation. 36 The maximal increase in impedance was attenuated by glucose treatment. These findings infer that increased glucose supported anaerobic metabolism 36 and so attenuated cellular swelling, consistent with evidence that hyperglycemia reduced ATP depletion during HI in piglets.…”
Section: Discussionmentioning
confidence: 96%
“…36 The maximal increase in impedance was attenuated by glucose treatment. These findings infer that increased glucose supported anaerobic metabolism 36 and so attenuated cellular swelling, consistent with evidence that hyperglycemia reduced ATP depletion during HI in piglets. 37…”
Section: Discussionmentioning
confidence: 96%
“…Cerebral blood flow and metabolic investigations in experimental animals of species other than the rat also support the notion that glucose is not deleterious to the immature brain undergoing hypoxiaischemia through the mechanism of enhanced tissue lactic production [Hope et al, 1988;Chao et al, 1989;Young et al, 1991]. However, hyperglycemia has been shown to increase ischemic brain damage in newborn pigs [LeBlanc et al, 1993].…”
Section: Studies In Other Speciesmentioning
confidence: 64%