The Effect of Elevated Mean Arterial Blood Pressure in Cervical Traumatic Spinal Cord Injury with Hemorrhagic Contusion

Mushlin, Harry; Lessing, Noah L; Wessell, Aaron; Chryssikos, Timothy; Pratt, Nathan; Caffes, Nicholas; Oliver, Jeffrey; Aarabi, Bizhan; Schwartzbauer, Gary

doi:10.1016/j.wneu.2020.08.163

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…This has been shown to correlate with improved neurological recovery by theoretically ensuring adequate spinal cord perfusion pressure and preventing secondary injury. In the context of associated spinal haemorrhage, a 2020 retrospective review concluded that elevated MAPs over 85 mm Hg for 7 days were not associated with a significantly increased risk of haemorrhagic expansion in those with cervical spine haemorrhagic contusions 26…”

Section: Discussionmentioning

confidence: 99%

Spinal subdural haemorrhage secondary to strenuous exercise and warfarin, complicated by acute ischaemic stroke

Liu,

McHugh,

2024

BMJ Case Rep

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Spinal subdural haemorrhage or haematoma (SSDH) is a rare condition that is often overlooked and missed on initial presentation due to its non-specific features that may mimic other more common pathologies. It is associated with high morbidity and mortality rates, with few evidence-based management principles, particularly during the subacute stages of recovery. In this report, we detail a case of SSDH associated with exercise and anticoagulation therapy, which was complicated by acute ischaemic stroke. SSDH should be suspected in cases of acute back pain without a clear alternative cause, particularly in coagulopathic individuals. Following treatment, early recommencement of anticoagulation therapy may be justified in certain cases where indicated, after careful consideration of the affected individual’s risk profile.

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Section: Discussionmentioning

confidence: 99%

Spinal subdural haemorrhage secondary to strenuous exercise and warfarin, complicated by acute ischaemic stroke

Liu,

McHugh,

2024

BMJ Case Rep

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“…In addition to supporting the idea that maintaining a normotensive state through pharmacological MAP elevation during the acute phase of SCI increases the likelihood of neurological recovery, this study also suggested that hypertension (MAP >94 mmHg) may have negative effects. Logistic regression analysis in acute cervical SCI patients suggest that increased MAP to the goal of >85 mmHg for 7 days post-injury did not increase the risk for hemorrhagic contusion expansion [ 54 ].…”

Section: Managing Acute Pathophysiology After Traumatic Scimentioning

confidence: 99%

Clinical Trials Targeting Secondary Damage after Traumatic Spinal Cord Injury

Khaing

Chen

Safarians

et al. 2023

IJMS

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Spinal cord injury (SCI) often causes loss of sensory and motor function resulting in a significant reduction in quality of life for patients. Currently, no therapies are available that can repair spinal cord tissue. After the primary SCI, an acute inflammatory response induces further tissue damage in a process known as secondary injury. Targeting secondary injury to prevent additional tissue damage during the acute and subacute phases of SCI represents a promising strategy to improve patient outcomes. Here, we review clinical trials of neuroprotective therapeutics expected to mitigate secondary injury, focusing primarily on those in the last decade. The strategies discussed are broadly categorized as acute-phase procedural/surgical interventions, systemically delivered pharmacological agents, and cell-based therapies. In addition, we summarize the potential for combinatorial therapies and considerations.

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The Effect of Elevated Mean Arterial Blood Pressure in Cervical Traumatic Spinal Cord Injury with Hemorrhagic Contusion

Cited by 2 publications

References 28 publications

Spinal subdural haemorrhage secondary to strenuous exercise and warfarin, complicated by acute ischaemic stroke

Spinal subdural haemorrhage secondary to strenuous exercise and warfarin, complicated by acute ischaemic stroke

Clinical Trials Targeting Secondary Damage after Traumatic Spinal Cord Injury

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