The effect of embryo glue on clinical pregnancy rate in frozen embryo transfers

Chao, Sheng D.; Schenkman, E.; Kim, S.; Kenigsberg, Daniel; Brenner, S.; Moodie, G.

doi:10.1016/j.fertnstert.2008.07.1185

Cited by 8 publications

(2 citation statements)

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“…In women who failed to conceive despite at least three previous embryo transfers, a 25% clinical pregnancy and 14.2% delivered pregnancy rate were achieved using EmbryoGlue, when compared with women not using EmbryoGlue (39.2% and 39.2% respectively; P > 0.05; Dietterich et al 2007). Among 120 cases, no statistical difference was found between clinical pregnancies in the control group and test group using EmbryoGlue (38% vs 42%) (Chao et al 2008). Similar results were obtained by Marek et al (2004).…”

Section: Gosupporting

confidence: 70%

Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep

Marei

Wathes

Raheem

et al. 2017

Reprod. Fertil. Dev.

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(200 words for RFD)An increasing number of reports suggests a role of hyaluronan (HA) in female reproduction and interest in its application in assisted reproduction is rising. However, there are contrasting data about the effectiveness of adding HA to the embryo-transfer medium on improving pregnancy rates. Using sheep as an experimental model, the studies reported here analysed the impact of HA infusion into the uterus on embryo attachment to uterine luminal epithelium (LE) and expression of selected markers of uterine receptivity. On Day 14 after natural mating (preattachment), uterine horns were infused with either (n = 4 each): PBS (control), HA (1 mg mL-1), HA + hyaluronidase 2 (Hyal2; 300 IU mL-1) or 4-methyl-umbelliferone (HA-synthesis inhibitor; 4MU, 1 mM). HA immunostaining on uterine sections collected on Day 17 was negative in the 4MU group and weak in the HA+Hyal2 group. In contrast to 4MU, which resulted in 100% attachment, HA infusion blocked embryo attachment in all treated animals.This was accompanied by the disappearance of mucin 1 and increased expression of osteopontin and CD44v6 in the LE of uteri with attached embryos. In conclusion, the presence of HA at the embryo-maternal interface during embryo implantation resulted in reduced endometrial receptivity and inhibited the interaction of trophoblasts with the LE, whereas clearance of HA favoured embryo attachment.3

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Section: Gosupporting

confidence: 70%

Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep

Marei

Wathes

Raheem

et al. 2017

Reprod. Fertil. Dev.

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“…Urman et al found that HA-enriched media increased the rate of clinical pregnancies and implantation on days 3 and 5 of ET. 6 Several authors state that HA-enriched media have not shown significant results in their study 2,19 and concluded that future research should show whether EG is the highest quality option for all patients or only for those patients in whom the quality of the embryo is poor, for patients in whom implantation has failed and older patients. 20 Nishihara et al 21 state that pregnancies, implantation, and abortion rates where media with different concentrations of HA was used during ET gives similar results.…”

Section: Discussionmentioning

confidence: 98%

Influence of EmbryoGlue® transfer medium on implantation of human embryos

Pavlović-Vasić¹,

Sibinčić²,

Milaković³

et al. 2021

Scripta Medica

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Introduction: Thanks to ever-growing advances in medical science, couples who are in the in vitro fertilisation (IVF) now have more options than ever to encase their chances at a successful pregnancy. One of the options is the use of EmbryoGlue (EG), that creates a bridge between the embryo and the uterus and provides protection to the embryo itself during the transfer process. Aim of this study was to determine whether EG medium is of greater importance for embryo implantation than conventional medium in assisted reproductive technology and compare the rate of embryo implantation with EG and conventional medium in relation to the quality of the embryo, the age of the patients and tobacco smoking. Methods: The retrospective study included 50 patients who used EG medium in embryo transfer (ET) and 50 patients in the control group using conventional medium. All patients underwent ET after stimulation of the cycle according to a short protocol. ETs were done on Day 2, 3, or 5 in the blastocyst stage. Age and smoking status were recorded. Results: Out of a total of 100 patients, 42 patients had successful implantation and positive b-hCG 15 days after ET. In a control group 38 % had positive b-hCG and in the group of patients who used EG 46 %. A higher rate of embryo implantation success was observed on the second day of transfer in the group of patients using EG. In the EG group a significant increase in the embryo implantation rate was observed in patients older than 35. In tobacco smokers the implantation rate was higher if they used EG during ET. Conclusion: EG medium had a positive effect on the second day of ET, patients above the age of 35 and patients who were tobacco smokers.

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Adherence compounds in embryo transfer media for assisted reproductive technologies

Bontekoe

Blake

Heineman

et al. 2010

Cochrane Database of Systematic Reviews

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There is evidence of an improved clinical pregnancy rate with the use of adherence compounds in ART cycles but no evidence of an effect on live birth rate. The increase in multiple pregnancy rate may be the result of the use of a combination of an adherence compound and a policy of transferring more than one embryo. Further studies of adherence compounds with single embryo transfer need to be undertaken.

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The effect of embryo glue on clinical pregnancy rate in frozen embryo transfers

Cited by 8 publications

References 0 publications

Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep

Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep

Influence of EmbryoGlue® transfer medium on implantation of human embryos

Adherence compounds in embryo transfer media for assisted reproductive technologies

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