The Effect of Endodontic Therapy on Periapical Exudate Neutrophil Elastase and Prostaglandin-E2 Levels

Alptekin, Nilgün Özlem; Arı, Hale; Haliloğlu, Seyfullah; Alptekin, Tuncay; Serpek, Behiç; Ataoğlu, Tamer

doi:10.1097/01.don.0000158010.43884.59

Cited by 25 publications

(34 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, an attempt was made to evaluate the COX-2 level influenced by TEGDMA in cultured dental pulp cells, which are essentially pulp fibroblast. Raised PGE 2 levels in pulp tissues and periapical exudate have been correlated with the failure of radiological and clinical outcome (Waterhouse et al 2002, Alptekin et al 2005. A recent study recorded COX-2 was induced by TEGDMA in RAW 264.7 cells, which are murine monocyte-macrophage cell line, in sub-lethal concentrations (0.1-0.4 mmol L )1 ) and shorter exposure time (1-24 h) (Lee et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Effect of triethylene glycol dimethacrylate on the cytotoxicity, cyclooxygenase‐2 expression and prostanoids production in human dental pulp cells

Chang

Huang

et al. 2012

Int Endodontic J

View full text Add to dashboard Cite

Triethylene glycol dimethacrylate induced cytotoxicity, cell cycle arrest and apoptosis in dental pulp cells, which was associated with the decline of cdc2, cyclin B1, cdc25C expression and elevation of p21 expression. Concomitantly, COX-2 expression, PGE(2) and PGF(2α) production increased. These effects may contribute to explain the pulpal damage and inflammation induced by TEGDMA after operative procedures.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of triethylene glycol dimethacrylate on the cytotoxicity, cyclooxygenase‐2 expression and prostanoids production in human dental pulp cells

Chang

Huang

et al. 2012

Int Endodontic J

View full text Add to dashboard Cite

show abstract

“…Thus, it was suggested that NE levels in periapical exudates may be a reliable marker for disease state of periapical lesions. It was also shown that periapical exudate NE levels were correlated with PGE2 levels and the canals with pus discharge contained higher NE and PGE2 total amounts than teeth without these signs [90]. …”

Section: Methodsmentioning

confidence: 99%

Pathogenesis of Apical Periodontitis: a Literature Review

Graunaite¹,

Lodienė²,

Mačiulskienė

2011

JOMR

102

View full text Add to dashboard Cite

ObjectivesThis review article discusses the host response in apical periodontitis with the main focus on cytokines, produced under this pathological condition and contributing to the degradation of periradicular tissues. The pace of research in this field has greatly accelerated in the last decade. Here we provide an analysis of studies published in this area during this period.Material and methodsLiterature was selected through a search of PubMed electronic database. The keywords used for search were pathogenesis of apical periodontitis cytokines, periapical granuloma cytokines, inflammatory infiltrate apical periodontitis. The search was restricted to English language articles, published from 1999 to December 2010. Additionally, a manual search in the cytokine production, cytokine functions and periapical tissue destruction in the journals and books was performed.ResultsIn total, 97 literature sources were obtained and reviewed. The topics covered in this article include cellular composition of an inflammatory infiltrate in the periapical lesions, mechanisms of the formation of the innate and specific immune response. Studies which investigated cytokine secretion and functions were identified and cellular and molecular interactions in the course of apical periodontitis described.ConclusionsThe abundance and interactions of various inflammatory and anti-inflammatory molecules can influence and alter the state and progression of the disease. Therefore, periapical inflammatory response offers a model, suited for the study of many facets of pathogenesis, biocompatibility of different materials to periapical tissues and development of novel treatment methods, based on the regulation of cytokines expression

show abstract

“…Prostaglandins type 2 (PGE2) are major mediators of local inflammatory processes, synthesized by the enzyme cyclooxygenase (COX), leading to the development of inflammatory symptoms in the gums and teeth, as in periodontitis (Chidiac et al, 2002;Alptekin et al, 2005). Throat "Pain" "An inflamed throat feels sore, it kind of hurts.…”

Section: Conditionsmentioning

confidence: 99%

Resilience and adaptation in the use of medicinal plants with suspected anti-inflammatory activity in the Brazilian Northeast

Júnior

Ladio

Albuquerque

2011

Journal of Ethnopharmacology

View full text Add to dashboard Cite

The Effect of Endodontic Therapy on Periapical Exudate Neutrophil Elastase and Prostaglandin-E2 Levels

Cited by 25 publications

References 28 publications

Effect of triethylene glycol dimethacrylate on the cytotoxicity, cyclooxygenase‐2 expression and prostanoids production in human dental pulp cells

Effect of triethylene glycol dimethacrylate on the cytotoxicity, cyclooxygenase‐2 expression and prostanoids production in human dental pulp cells

Pathogenesis of Apical Periodontitis: a Literature Review

Resilience and adaptation in the use of medicinal plants with suspected anti-inflammatory activity in the Brazilian Northeast

Contact Info

Product

Resources

About