The effect of endogenously released glucose, insulin, glucagon-like peptide 1, ghrelin on cardiac output, heart rate, stroke volume, and blood pressure

Hlebowicz, Joanna; Lindstedt, Sandra; Björgell, Ola; Dencker, Magnus

doi:10.1186/1476-7120-9-43

Cited by 22 publications

(16 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies reported an early and short-term rise of isoprene concentration in exhaled breath when cardiac output increased [54,55]. Recent investigations support our finding that changes in blood glucose and insulin concentrations may influence the heart rate, cardiac output, and blood pressure [54,56].…”

Section: Discussionsupporting

confidence: 54%

Exhalation pattern changes during fasting and low dose glucose treatment in rats

et al. 2015

View full text Add to dashboard Cite

The analysis of exhaled metabolites has become a promising field of research in recent decades. Several volatile organic compounds reflecting metabolic disturbance and nutrition status have even been reported. These are particularly important for long-term measurements, as needed in medical research for detection of disease progression and therapeutic efficacy. In this context, it has become urgent to investigate the effect of fasting and glucose treatment for breath analysis. In the present study, we used a model of ventilated rats that fasted for 12 h prior to the experiment. Ten rats per group were randomly assigned for continuous intravenous infusion without glucose or an infusion including 25 mg glucose per 100 g per hour during an observation period of 12 h. Exhaled gas was analysed using multicapillary column ion-mobility spectrometry. Analytes were identified by the BS-MCC/IMS database (version 1209; B & S Analytik, Dortmund, Germany). Glucose infusion led to a significant increase in blood glucose levels (p < 0.05 at 4 h and thereafter) and cardiac output (p < 0.05 at 4 h and thereafter). During the observation period, 39 peaks were found collectively. There were significant differences between groups in the concentration of ten volatile organic compounds: p < 0.001 at 4 h and thereafter for isoprene, cyclohexanone, acetone, p-cymol, 2-hexanone, phenylacetylene, and one unknown compound, and p < 0.001 at 8 h and thereafter for 1-pentanol, 1-propanol, and 2-heptanol. Our results indicate that for long-term measurement, fasting and the withholding of glucose could contribute to changes of volatile metabolites in exhaled air.

show abstract

Section: Discussionsupporting

confidence: 54%

Exhalation pattern changes during fasting and low dose glucose treatment in rats

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The food effect remained even after implementation of HR correction methodologies and appeared to be unassociated with direct changes in HR. It is recognized that other physiological changes (eg, possibly autonomic perturbations) take place after a meal and that those specific variables were not accounted for within this analysis . Nevertheless, the model performed well in capturing the QT and has significant implications for QT study assessment following a meal or when a cohort is receiving a medication that influences postprandial glucose concentrations.…”

Section: Discussionmentioning

confidence: 99%

Influence of Meals and Glycemic Changes on QT Interval Dynamics

Cirincione

Sager

Mager

2017

The Journal of Clinical Pharma

View full text Add to dashboard Cite

Thorough QT/QTc studies have become an integral part of early drug development programs, with major clinical and regulatory implications. This analysis expands on existing pharmacodynamic models of QT interval analysis by incorporating the influence of glycemic changes on the QT interval in a semimechanistic manner. A total of 21 healthy subjects enrolled in an open‐label phase 1 pilot study and provided continuous electrocardiogram monitoring and plasma glucose and insulin concentrations associated with a 24‐hour baseline assessment. The data revealed a transient decrease in QTc, with peak suppression occurring approximately 3 hours after the meal. A semimechanistic modeling approach was applied to evaluate temporal delays between meals and subsequent changes that might influence QT measurements. The food effect was incorporated into a model of heart rate dynamics, and additional delayed effects of the meal on QT were incorporated using a glucose‐dependent hypothetical transit compartment. The final model helps to provide a foundation for the future design and analysis of QT studies that may be confounded by meals. This study has significant implications for QT study assessment following a meal or when a cohort is receiving a medication that influences postprandial glucose concentrations.

show abstract

“…The correlation between heart rate and MPI has however been found to be insignificant [1] or weak [17]. Physiological changes in the levels of glucose, insulin, glucagon-like peptide 1 (GLP-1) and ghrelin may also influence the activity of the heart [18]. Moreover, it is known that insulin has positive chronotropic and inotropic effects on the heart [19], and the hormone GLP-1 has been shown to improve left ventricular function [20, 21].…”

Section: Discussionmentioning

confidence: 99%

“…The hormone ghrelin has been shown to increase cardiac output (CO) and stroke volume (SV) [22–24]. The ingestion of food has also been shown to decrease the diastolic blood pressure [18]. Considering the changes in hemodynamics with increased cardiac output and altered loading conditions it is not surprising that MPI – and more specifically the isovolumetric contraction and relaxation - changes accordingly.…”

Section: Discussionmentioning

confidence: 99%

Effect of food intake on myocardial performance index

Gårdinger

Dieden

Hlebowicz

et al. 2017

Cardiovasc Ultrasound

Self Cite

View full text Add to dashboard Cite

BackgroundMyocardial performance index (MPI) has been investigated in a variety of populations, but the effect of food intake has not been evaluated. We assessed whether myocardial performance index is affected by food intake in healthy subjects.MethodsTwenty-three healthy subjects aged 25.6 ± 4.5 years were investigated. MPI was measured before, 30 min after, and 110 min after a standardized meal.ResultsMPI decreased significantly (P < 0.05) from fasting values 30 min after the meal, and had almost returned to baseline after 110 min. MPI decreased from 0.28 ± 0.06 (fasting) to 0.20 ± 0.07 30 min after eating. At 110 min after eating the index value was almost back to the baseline value 0.26 ± 0.06. (P = 0.15).ConclusionsThis study shows that myocardial performance index is affected by food intake in healthy subjects.

show abstract

The effect of endogenously released glucose, insulin, glucagon-like peptide 1, ghrelin on cardiac output, heart rate, stroke volume, and blood pressure

Cited by 22 publications

References 54 publications

Exhalation pattern changes during fasting and low dose glucose treatment in rats

Exhalation pattern changes during fasting and low dose glucose treatment in rats

Influence of Meals and Glycemic Changes on QT Interval Dynamics

Effect of food intake on myocardial performance index

Contact Info

Product

Resources

About