The effect of endometrial scratch injury on pregnancy outcome in women with previous intrauterine insemination failure: A randomized clinical trial

Ashrafi, Mahnaz; Tehraninejad, Ensieh Shahrokh; Haghiri, Mansooreh; M, Masomi; Sadatmahalleh, Shahideh Jahanian; Arabipoor, Arezoo

doi:10.1111/jog.13401

Cited by 20 publications

(28 citation statements)

References 32 publications

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“…Transferred embryo quality and endometrium receptivity are the most important factors influencing the implantation and clinical pregnancy rates following embryo transfer . Despite the dynamic nature of the implantation which requires both embryonic and endometrial involvement, first, the endometrium must be adequately prepared to receive the embryo into the uterine wall; therefore, maternal changes in the endometrium can affect implantation .…”

Section: Introductionmentioning

confidence: 99%

Does low‐dose aspirin improve pregnancy rate in women undergoing frozen‐thawed embryo transfer cycle? A pilot double‐blind, randomized placebo‐controlled trial

Madani

Ahmadi

Jahangiri

et al. 2018

J of Obstet and Gynaecol

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Section: Introductionmentioning

confidence: 99%

Does low‐dose aspirin improve pregnancy rate in women undergoing frozen‐thawed embryo transfer cycle? A pilot double‐blind, randomized placebo‐controlled trial

Madani

Ahmadi

Jahangiri

et al. 2018

J of Obstet and Gynaecol

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“…In 2007, in a study conducted in Iran, they were able to observe that if a mechanical injury was caused in the endometrium, this would undergo an inflammatory process, followed by a chain-secretion of cytokines, prostaglandins, chemotactic factors, and growth factors that later induced a repair process of the endometrial tissue, called "Healing endometrial" 4 .…”

Section: Medicina Universitariamentioning

confidence: 99%

“…This repaired tissue promotes the attachment of the embryo and the endometrium, thus increasing implantation rate and, consequently, pregnancy rate 4 .…”

Section: Medicina Universitariamentioning

confidence: 99%

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Effects on endometrial mechanical stimulation (healing) in normal intrauterine insemination cycles

González-Báez¹,

Puente-Villarreal²,

Lemini-Camarillo³

et al. 2020

RMU

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Objective:The objective of the study was to investigate the effect of healing on the results of intrauterine insemination cycles. Healing stimulation consists of placing a pipelle insemination cannula vaginally through the cervix, until it touches the uterine fundus and remove it. Material and methods: An experimental, longitudinal, prospective, comparative, and non-blinded study was performed with patients from the "Dr. José Eleuterio González, " University Hospital, who attended the Center for Reproductive Medicine (CeUMER) who underwent controlled ovarian stimulation and intrauterine insemination. Two groups were formed: a control group consisting of 40 cycles and a study group of 40 cycles, in which healing was performed on the day of the application of choriogonadotropin alfa as the trigger for ovulation. Results: A clinical pregnancy rate of 17.5% and biochemical pregnancy rate of 5% were found in the endometrial mechanical stimulation study group undergoing intrauterine inseminations, while the control group obtained a clinical pregnancy rate of 20%. They did not show biochemical pregnancies in the control group with a biochemical pregnancy rate without having a statistical significance (p = 0.15). There was no significant impact on clinical pregnancy when performing healing. Conclusions: There was no significant impact on the clinical pregnancy rate in the study group when healing was performed. The presence of biochemical pregnancy was evidenced only in the group with stimulation, but no significant value was presented. The other variables that were evaluated during the study did not have a significant difference between the two groups, nor in the association with clinical and biochemical pregnancy.

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“…Randomized controlled trials have also shown improvements of intrauterine insemination (IUI) results in women subjected to controlled endometrial injury prior to insemination [9,10]. However, there were some other studies that have shown no benefit from the procedure [15,16].…”

Section: Introductionmentioning

confidence: 99%

Endometrial scratch for infertile polycystic ovary syndrome (PCOS) women undergoing laparoscopic ovarian drilling: a randomized controlled trial

Gibreel

Ali

Hemida

et al. 2019

Middle East Fertil Soc J

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Background: Women with polycystic ovarian syndrome (PCOS) may undergo laparoscopic ovarian drilling (LOD). To find out whether endometrial scratch, at time of LOD, could improve live birth rate in subfertile women with PCOS, a randomized controlled trial was conducted. Results: There was no evidence of a significant difference in cumulative live birth rate between women who had endometrial scratch at time of LOD and those who had LOD only (38.1% and 34.3% respectively, odds ratio 1.18, 95% CI (0.67, 2.07); p = 0.57). Conclusion: Women undergoing laparoscopic ovarian drilling should not be subjected to endometrial scratch as it does not lead to improvement in live birth rate. The study was prospectively registered on 25 April 2014 in ClinicalTrials.gov with identifier number NCT02140398. Patients and methods Study design and participants We conducted a parallel randomized controlled trial (RCT), approved by our university ethics committee. We approached all infertile women with anovulatory infertility due to PCOS referred for laparoscopic ovarian drilling in Mansoura University Teaching Hospitals in Mansoura,

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The effect of endometrial scratch injury on pregnancy outcome in women with previous intrauterine insemination failure: A randomized clinical trial

Cited by 20 publications

References 32 publications

Does low‐dose aspirin improve pregnancy rate in women undergoing frozen‐thawed embryo transfer cycle? A pilot double‐blind, randomized placebo‐controlled trial

Does low‐dose aspirin improve pregnancy rate in women undergoing frozen‐thawed embryo transfer cycle? A pilot double‐blind, randomized placebo‐controlled trial

Effects on endometrial mechanical stimulation (healing) in normal intrauterine insemination cycles

Endometrial scratch for infertile polycystic ovary syndrome (PCOS) women undergoing laparoscopic ovarian drilling: a randomized controlled trial

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