The effect of endurance exercise-induced lactacidosis on biochemical markers of bone turnover

Herrmann, Markus; Müller, Monika; Scharhag, Jürgen; Sand-Hill, Marga; Kindermann, Wilfried; Herrmann, Wolfgang

doi:10.1515/cclm.2007.282

Cited by 35 publications

(36 citation statements)

References 60 publications

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“…which is greater than the 17%-46% increase reported in previous studies (Barry et al 2011;Guillemant et al 2004;Herrmann et al 2007;Maïmoun et al 2006). This discrepancy may be due to the 3-fold longer duration of cycling in the current study.…”

Section: B † † †contrasting

confidence: 60%

“…Pearson's linear regression was used to investigate correlations between PTH, cortisol, serum or sweat calcium concentration, total energy expenditure, and the concentration of the bone markers. Based on the recent study of Barry et al (2011) where the average SD for the change in ␤-CTX from pre-to postexercise was 0.25, a sample size of 10 participants will afford 74%-88% statistical power to identify the smallest worthwhile change in serum ␤-CTX concentration of 0.23-0.28 ng·mL −1 as has been previously observed where cycling persisted for only 1 h (Barry et al 2011;Herrmann et al 2007). Data are presented as means ± SD.…”

Section: Discussionmentioning

confidence: 96%

“…Previous studies have evaluated the bone turnover marker response following only a single short (1 h) cycling bout (Barry et al 2011;Guillemant et al 2004;Herrmann et al 2007;Maïmoun et al 2006), and report increases in the bone resorption marker, C-terminal teleopeptide of type I collagen (␤-CTX), with no change (Barry et al 2011;Guillemant et al 2004;Herrmann et al 2007) or small relative increases in bone formation marker, bone alkaline phosphotase (bone-ALP), (Maïmoun et al 2006) compared with resting values. Thus, bone resorption is stimulated by a bout of short duration cycling, but it is unknown whether the response will be magnified by longer bouts of cycling.…”

Section: Introductionmentioning

confidence: 99%

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Bone resorption is suppressed immediately after the third and fourth days of multiday cycling but persistently increased following overnight recovery

Oosthuyse

Badenhorst

Avidon

2014

Appl. Physiol. Nutr. Metab.

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Previous studies suggest that seasoned cyclists may incur a low bone mineral density. This study investigated the effect of multiday cycling on bone turnover. Ten male cyclists completed 4 consecutive days of cycling for 3 h·day −1 . Sweat calcium excretion during exercise and serum calcium, cortisol, bone formation marker (bone alkaline phosphotase (bone-ALP)), bone resorptive marker (C-terminal telopeptide of type I collagen (␤-CTX)), and parathyroid hormone concentration were measured before and immediately postexercise each day. Serum ␤-CTX concentration increased from pre-to postcycling on days 1 and 2 (p = 0.01) (day 1: 0.31 ± 0.14 to 0.60 ± 0.4 ng·mL −1 ; day 2: 0.58 ± 0.26 to 0.87 ± 0.42 ng·mL −1 ), while serum bone-ALP concentration remained unchanged. Conversely, on days 3 and 4 both serum ␤-CTX (day 3: 0.60 ± 0.26 to 0.43 ± 0.26 ng·mL −1 , p < 0.05; day 4: 0.63 ± 0.21 to 0.43 ± 0.22 ng·mL −1 , p < 0.001) and bone-ALP (p < 0.01) response to exercise was suppressed. Interestingly, calcium lost to sweat and postexercise serum cortisol concentration were also significantly lower on days 3 and 4 than on day 1 (p < 0.05). However, both serum ␤-CTX (102%-124%) and bone-ALP (25%-29%) remained persistently elevated after 21 h of overnight recovery on all successive days compared with day 1 pre-exercise, where the percentage increase was greater for ␤-CTX (p < 0.05). Bone resorption, immediately following prolonged cycling, is acutely reduced by the third and fourth consecutive days and is coincident to reduced sweat calcium excretion and cortisol concentration. However, multiday cycling imposes a persistent increase in bone resorption following overnight recovery.Key words: bone turnover, bone metabolism, cycling, cortisol, sweat calcium, parathyroid hormone. Résumé :Des études antérieures suggèrent que des cyclistes d'expérience peuvent présenter une faible densité minérale osseuse. Cette étude analyse l'effet de plusieurs jours de vélo sur le renouvellement du tissu osseux. Dix cyclistes masculins participent à 4 jours consécutifs de vélo à raison de 3 h·jour -1 . Tous les jours, avant et immédiatement après l'exercice à vélo, on évalue l'excrétion de calcium dans la sueur au cours de l'exercice ainsi que les variables suivantes : calcium sérique, cortisol, marqueur de la formation osseuse (phosphatase alcaline osseuse (« ALP » osseuse)), marqueur de résorption osseuse (télopeptide c-terminal du collagène de type 1 (« ␤-CTX »)) et concentration de la parathormone. La concentration sérique de ␤-CTX augmente du début à la fin de l'exercice aux jours 1 et 2 (p = 0,01) (jour 1: de 0,31 ± 0,14 à 0,60 ± 0,4 ng·mL -1 ; jour 2: de 0,58 ± 0,26 à 0,87 ± 0,42 ng·mL -1 ), mais la concentration sérique d'ALP osseuse ne varie pas. Par contre, aux jours 3 et 4, la concentration sérique de ␤-CTX (jour 3: de 0,60 ± 0,26 à 0,43 ± 0,26 ng·mL -1 , p < 0,05; jour 4: de 0,63 ± 0,21 à 0,43 ± 0,22 ng·mL -1 , p < 0,001) et d'ALP osseuse (p < 0,01) diminue au cours de l'exercice. Curieusement, la perte de calcium dans la su...

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Section: B † † †contrasting

confidence: 60%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Bone resorption is suppressed immediately after the third and fourth days of multiday cycling but persistently increased following overnight recovery

Oosthuyse

Badenhorst

Avidon

2014

Appl. Physiol. Nutr. Metab.

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“…Prolonged, endurance exercise increases P-CTX [15][16][17][18][19] but again, bone formation markers are largely unresponsive [15,16,18,19], suggesting that prolonged exercise might result in a transient negative remodelling balance. This acute response may be of significance to athletic populations as the net effects of changes in bone resorption and formation have been implicated in both stress fractures [20] and changes in bone mineral density (BMD) [21].…”

Section: 3mentioning

confidence: 99%

Effect of fasting versus feeding on the bone metabolic response to running

Scott

Sale

Greeves³

et al. 2012

Bone

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Abbreviations: ACa, albumin-adjusted calcium; Bone ALP, bone alkaline phosphatase; BMD, bone mineral density; P-CTX, C-terminal telopeptide region of collagen type 1; CHO, carbohydrate; FAST, overnight fast from 21:00; FED, a standardised breakfast consumed at 08:15; GLP-1, glucagon-like peptide-1; GLP-2, glucagon-like peptide-2; GIP, glucosedependent insulinotropic polypeptide; LMM, linear mixed model; OC, osteocalcin; OPG, osteoprotegerin; P1NP, N-terminal propeptides of procollagen type 1; PTH, parathyroid hormone; PO4, phosphate; RER, respiratory exchange ratio; RPE, ratings of perceived exertion; VO2, oxygen uptake; V02max, maximal rate of oxygen uptake. ABSTRACTIndividuals often perform exercise in the fasted state, but the effects on bone metabolism are not currently known. We compared the effect of an overnight fast with feeding a mixed meal on the bone metabolic response to treadmill running. Ten, physically-active males aged 28 ± 4 y (mean ± 1SD) completed two, counterbalanced, 8 d trials. After 3 d on a standardised diet, participants performed 60 min of treadmill running at 65% V02max on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before and during exercise, for 3h after exercise, and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for the c-terminal telopeptide region of collagen type 1 (P-CTX), n-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone alkaline phosphatase (bone ALP), parathyroid hormone (PTH), albumin-adjusted calcium, phosphate, osteoprotegerin (OPG), Cortisol, leptin and ghrelin. Only the P-CTX response was significantly affected by feeding. Pre-exercise concentrations decreased more in FED compared with FAST (47% vs 26%, P < 0.001) but increased during exercise in both groups and were not significantly different from baseline at 1 h post-exercise. At 3 h post-exercise, concentrations were decreased (33%, P < 0.001) from baseline in FAST and significantly lower (P < 0.001) than in FED. P1NP and PTH increased, and OC decreased during exercise. Bone markers were not significantly different from baseline on FU1-FU4.Fasting had only a minor effect on the bone metabolic response to subsequent acute, endurance exercise, reducing the duration of the increase in P-CTX during early recovery, but having no effect on changes in bone formation markers. The reduced duration of the P-CTX response with fasting was not fully explained by changes in PTH, OPQ leptin or ghrelin.

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“…The change in osteocalcin after a single bout of exercise is unclear; it could decrease, 19 remain unchanged 27 or increase. 16 , 42 Conversely, the change in osteocalcin after a period of training is more obvious and tends to increase.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Walking and Bench-Step Exercise on Osteocalcin and CTX-1 in Post-Menopausal Women With Osteopenia

Haryono

Tulaar

Sudoyo

et al. 2017

J. Musculoskelet. Res.

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Purpose: Bench-step exercise produces biomechanical movements beneficial to improve bone remodeling. However, no studies have confirmed the effects of bench-step exercise (BE) on bone formation and resorption. The goal of this study is to compare the effects of bench-step and walking exercise (WE) on changes in osteocalcin and CTX-1 levels. Methods: Fifty-nine sedentary post-menopausal women with osteopenia (T-score between À1 and À2.5) were randomly divided into two groups: WE group (n ¼ 29) and BE group (n ¼ 30). Subjects performed 12 weeks of exercise. The osteocalcin and CTX-1 levels were analyzed using enzyme-linked immunosorbent assay. Independent t-test or Wilcoxon test was used to analyze the osteocalcin and CTX-1 levels. The difference in changes in the osteocalcin and CTX-1 between the groups before and after was analyzed using Mann-Whitney test. Results: The results showed a significant increase in the osteocalcin and CTX-1 levels in both groups (P < 0:05). The increased levels of osteocalcin between groups were not statistically different (P > 0:367). The increase in CTX-1 resulting from BE was lower than that from WE (P < 0:048). Conclusion: This study indicates that BE may inhibit resorption stronger than WE.

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The effect of endurance exercise-induced lactacidosis on biochemical markers of bone turnover

Abstract: Anaerobic exercise does not systemically affect bone turnover, suggesting that exercise-induced acidosis is not involved in the pathogenesis of stress fractures.

Cited by 35 publications

References 60 publications

Bone resorption is suppressed immediately after the third and fourth days of multiday cycling but persistently increased following overnight recovery

Bone resorption is suppressed immediately after the third and fourth days of multiday cycling but persistently increased following overnight recovery

Effect of fasting versus feeding on the bone metabolic response to running

Comparison of the Effects of Walking and Bench-Step Exercise on Osteocalcin and CTX-1 in Post-Menopausal Women With Osteopenia

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