Background: Entrepreneurship plays a strategic role in increasing a country's economic growth and can also provide new jobs so that it can reduce the number of unemployed. Objective: To reveal the effect of emotional intelligence, spiritual intelligence, and social intelligence on entrepreneurial intention through self-leadership as a mediating variable. Method: The study used a quantitative approach with survey methods, the sample consisted of 107 final year students majoring in informatics and computer at STMIK Bina Patria consisting of 48 males and 59 females. Data were collected by using a questionnaire and analyzed by using Partial Least Square (PLS). Results: Emotional intelligence influenced self-leadership. Spiritual intelligence influenced significantly on self-leadership. Social intelligence influenced self-leadership. Emotional intelligence influenced entrepreneurship intention. Self-leadership influenced directly on entrepreneurship intention. Social intelligence influenced directly entrepreneurship intention. Meanwhile, self-leadership can successfully mediate the influence of emotional intelligence, spiritual intelligence, and social intelligence on entrepreneurship intention. Conclusions: The results showed that emotional intelligence, spiritual intelligence, and spiritual intelligence influenced the entrepreneurship intention mediated by self-leadership. This is an empirical confirmation of the strategic role of emotional intelligence, spiritual intelligence, and social intelligence in developing self-leadership to influence the entrepreneurial intention of the students.