The constant body temperature of homeotherms is the net result of the balance between heat production and heat loss. This balance is achieved through changes in physical and chemical functions mediated by neural mechanisms.Body temperature can be measured at a number of sites on the animal body; e.g. oral, rectal and axillary temperatures are often used clinically to indicate the deep body temperature. However, Benzinger (1961) suggests that because of its considerable thermal inertia, rectal temperature is not a reliable index of deep body temperature and although it may be a useful clinical indicator, it is not truly representative of the temperature which stimulates the heat-production or heat-conservation mechanisms.While it is unlikely that the temperature of any one location is truly representative of the deep body temperature, that of the blood supplying the brain seems to provide a better measure of the changes which affect thermoregulatory mechanisms than do any of the sites where body temperature is commonly measured. However, it was not until Bligh (1957 a) successfully implanted thermocouples in the bicarotid trunk of sheep tbat it became possible to keep the temperature of the blood flowing to the brain under constant observation for prolonged periods in the intact, conscious animal. This procedure has the disadvantage of requiring surgery which limits its application to a small number of animals at any given time. On the other hand, the non-surgical technique of measuring the temperature of the tympanic membrane (Benzinger, 1959) does not readily lend itself to animal research because each animal must be thoroughly trained to permit this kind of treatment. Thus, an attempt was made in this study to find a readily accessible location on the body of sheep which closely follows the temperature of the internal carotid artery and which could be used under a variety of experimental conditions.