The Effect of Epidural Somatostatin on Postoperative Pain

Chrubasik, J.; Meynadier, J.; Scherpereel, P; Wünsch, Erich

doi:10.1213/00000539-198511000-00009

Cited by 78 publications

(23 citation statements)

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“…Third, intrathecally applied SOM inhibits motor reflexes in response to noxious stimuli and reduces c-Fos expression and mechanical hyperalgesia in neuropathic pain model (Mollenholt et al, 1988;Tsai et al, 2002). Finally, SOM has been shown to be analgesic when given systemically to patients with cluster headache, or when given intrathecally to patients with cancer pain or postoperative pain (Sicuteri et al, 1984;Chrubasik et al, 1985;Meynadier et al, 1985;Penn et al, 1992;Paice et al, 1996). Collectively, these findings suggest that SOM plays a significant role in the transmission of nociceptive information.…”

Section: Introductionmentioning

confidence: 92%

Effects of Somatostatin on the Responses of Rostrally Projecting Spinal Dorsal Horn Neurons to Noxious Stimuli in Cats

Jung

Lee

et al. 2008

Korean J Physiol Pharmacol

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Somatostatin (SOM) is a widely distributed peptide in the central nervous system and exerts a variety of hormonal and neural actions. Although SOM is assumed to play an important role in spinal nociceptive processing, its exact function remains unclear. In fact, earlier pharmacological studies have provided results that support either a facilitatory or inhibitory role for SOM in nociception. In the current study, the effects of SOM were investigated using anesthetized cats. Specifically, the responses of rostrally projecting spinal dorsal horn neurons (RPSDH neurons) to different kinds of noxious stimuli (i.e., heat, mechanical and cold stimuli) and to the Aδ -and C-fiber activation of the sciatic nerve were studied. Iontophoretically applied SOM suppressed the responses of RPSDH neurons to noxious heat and mechanical stimuli as well as to C-fiber activation. Conversely, it enhanced these responses to noxious cold stimulus and Aδ -fiber activation. In addition, SOM suppressed glutamate-evoked activities of RPSDH neurons. The effects of SOM were blocked by the SOM receptor antagonist cyclo-SOM. These findings suggest that SOM has a dual effect on the activities of RPSDH neurons; that is, facilitation and inhibition, depending on the modality of pain signaled through them and its action site.

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Section: Introductionmentioning

confidence: 92%

Effects of Somatostatin on the Responses of Rostrally Projecting Spinal Dorsal Horn Neurons to Noxious Stimuli in Cats

Jung

Lee

et al. 2008

Korean J Physiol Pharmacol

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“…Whether intrathecal administration of SST antagonist would have had an antinociceptive effect is an important question considering the fact that SST administration itself could prove neurotoxic (Gaumann and Yaksh, 1988;Mollenholt et al, 1994). Intriguingly, intrathecal administration of SST in humans (Chrubasik et al, 1985;Mollenholt et al, 1994) and in rats (Chapman and Dickenson, 1992) produced antinociception. While the exact reason for these findings needs to be studied, it may be hypothesized that this could have been due to diffusion rostrally to the brain as is often noted after intrathecal morphine treatment, sometimes with near-fatal or fatal consequences (Carvalho, 2008).…”

Section: Discussionmentioning

confidence: 99%

Role of Somatostatin and Somatostatin Receptor type 2 in Postincisional Nociception in Rats

et al. 2015

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“…The use of SRIF as a spinal pain killer in clinical practice was first described by Chrubasik et al [70][71][72]. In the 15 years since this first indication, multiple studies have been carried out in various countries despite the fact that the clinical use of SRIF has often achieved non-univocal results [73,74], both in its use for patients with cancer in the terminal stage [75] and in postoperative pain [76].…”

Section: Analgesic Action Of Srif Via Spinal Administrationmentioning

confidence: 99%

The epidural and intrathecal administration of somatotrophin-release inhibiting factor: Native and synthetic analogues

Beltrutti¹,

Moessinger²,

Varrassi

2000

Current Review of Pain

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It is well-known that morphine is the king of analgesics. It is widely used, and administered in various ways for the control of acute and chronic pain states. There are, however, certain types of pain and certain clinical conditions in which morphine cannot be used due to the risk of possible complications. These are usually pain states associated with intracranial hypertension, the presence of serious respiratory problems, the onset of major opioid tolerance, persistent vomiting, and so on. The search for "alternative analgesics" has been in progress for a decade, alternatives that could be used alone or in combination for spinal administration in the treatment of complex chronic pain states and with a low incidence of secondary effects. Today, research is carefully assessing the clinical effectiveness and the side effects of a series of drugs for spinal administration, that is, epidural or intrathecal, such as the new narcotics, alpha-2 agonists, central muscle relaxants, calcitonin, and local anesthetics. In this alternative analgesic category we have to mention the somatotrophin-release inhibiting factor (SRIF), which is an ubiquitous native hormone with widespread, predominantly inhibitory actions, and octreotide, its synthetic analogue. In this article we review the literature on the natural drug and its synthetic analogue, paying particular attention to the problems connected with intraspinal administration and analgesic properties.

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The Effect of Epidural Somatostatin on Postoperative Pain

Cited by 78 publications

References 0 publications

Effects of Somatostatin on the Responses of Rostrally Projecting Spinal Dorsal Horn Neurons to Noxious Stimuli in Cats

Effects of Somatostatin on the Responses of Rostrally Projecting Spinal Dorsal Horn Neurons to Noxious Stimuli in Cats

Role of Somatostatin and Somatostatin Receptor type 2 in Postincisional Nociception in Rats

The epidural and intrathecal administration of somatotrophin-release inhibiting factor: Native and synthetic analogues

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