The effect of epidurally administered dexamethasone with lignocaine for post-operative analgesia in dogs undergoing ovariohysterectomy. A dose-response study

Hermeto, Larissa Corrêa; Rossi, Rafael de; Bicudo, Natalia de Andrade; Assis, Klebs Tavares; Escobar, Lucas Latta; Camargo, Pedro Santana de

doi:10.1590/s0102-865020170040000008

Cited by 9 publications

(5 citation statements)

References 30 publications

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“…While evaluating the use of lidocaine through epidural administration, previous studies (DeRossi et al, 2016) also observed that the animals that received only lidocaine required rescue analgesia after two hours in the postoperative period. These results are similar in female dogs subjected to ovariohysterectomy that received only lumbosacral epidural lidocaine (Hermeto et al, 2017).…”

Section: Discussionsupporting

confidence: 63%

Analgesic effect of epidural maropitant and the combination of maropitant and lidocaine in cats subjected to ovariohysterectomy

Corrêa¹,

Niella²,

Oliveira³

et al. 2022

RSD

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The present study aimed to evaluate the efficacy of epidural maropitant administered with or without lidocaine for post-operative analgesia in cats. Forty cats submitted to epidural administration of treatments followed by ovariohysterectomy were assessed in this study. The cats were randomly distributed into experimental groups: epidural control group (ECG), which received saline; epidural lidocaine group (ELG), which received 3 mg/kg of 2% lidocaine without vasoconstrictor; epidural maropitant group (EMG), which received 1 mg/kg of maropitant; and epidural lidocaine and maropitant group (ELMG), which received 3 mg/kg of 2% lidocaine without vasoconstrictor and 1 mg/kg of maropitant. In all groups, sacrococcygeal epidural administration was performed. Physiological variables were measured during the surgical procedure. Post-operative pain was assessed over six hours by using a visual analogue scale and a multidimensional scale for assessment of post-operative pain in cats. During the surgical procedure, the heart rate in the ELMG was lower than that in the EMG. The ECG required a higher quantity of rescue analgesia in the post-operative period. The EMG and ELMG showed lower pain scores than the ECG. Epidural administration of lidocaine and maropitant, alone or in combination, provided similar analgesic effects in the post-operative period. Although the results indicate analgesic effects of lidocaine and maropitant used alone for two hours and the combination for three hours, the clinical use is limited because the duration of analgesia is too short for postoperative analgesia.

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Section: Discussionsupporting

confidence: 63%

Analgesic effect of epidural maropitant and the combination of maropitant and lidocaine in cats subjected to ovariohysterectomy

Corrêa¹,

Niella²,

Oliveira³

et al. 2022

RSD

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“…The anesthetist used 22G-gauge Touhy-type epidural needles. The method was confirmed using the loss resistance technique (Valverde 2008;Hermeto et al 2017). Dogs were randomly assigned to three experimental groups: the lidocaine -control-group (GL, n = 7) medicated with 2 mg Kg -1 ; the lidocaine-fentanyl group (GLF, n = 7) that received the same dose of lidocaine in combination with 3 µg Kg -1 of fentanyl; and the lidocaine-morphine group (GLM, n = 7) that received the same dose of lidocaine plus morphine at 0.1 mg Kg -1 .…”

Section: Experimental Designmentioning

confidence: 99%

Assessment of thermal response, cardiorespiratory parameters and post-operative analgesia in dogs undergoing ovariohysterectomy with different combinations of epidural analgesia and isoflurane

Casas-Alvarado¹,

Mota-Rojas²,

Hernández-Ávalos³

et al. 2023

J. Anim. Behav. Biometeorol.

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This study aimed to evaluate the thermal response of the eyelids and lacrimal gland of the left eye (LETG) through infrared thermography (IRT), cardiorespiratory parameters, and their association with nociception and pain in bitches undergoing elective ovariohysterectomy (OVH) anesthetized with isoflurane and epidural analgesia. Twenty-one healthy bitches of different breeds were randomized into three groups receiving epidural blocks: GL (n=7), lidocaine (2 mg Kg-1); GLF (n=7), lidocaine (2 mg Kg-1) and fentanyl (3 µg Kg-1); and GLM (n=7), lidocaine (2 mg Kg-1) with morphine (0.1 mg Kg-1). IRT and cardiorespiratory parameters were evaluated at baseline (Ebasal), thirty minutes before anesthetic premedication, and at different surgical events: first incision (EInc), ligature and section of the left (ELoV), and right (ERoV) ovarian pedicle, ligature, and re-section of the cervix (EUt), and skin suture (ESut). The assessment of acute pain in the immediate post-operative period was registered at E1h, E2h, and E3h using IRT, the Dynamic Interactive Visual Analogic Scale (DIVAS), and the University of Melbourne Pain Scale (UMPS) scales. The results showed a statistically significant decrease in the lower eyelid surface temperature (LELT) during EInc for GL (32.9°C ± 0.62), in comparison to GLF (34.2°C ± 0.62) and GLM (35.3°C ± 0.62) (P = 0.006). Regarding LETG, a significant increase (P = 0.03) in the IRT of Ebasal (36.8°C ± 0.63) and EInc (36.1°C ± 0.63) for GLM was observed in comparison to the thermographic values for both perioperative events and groups. The GLM showed a significant decrease in IRT values of ERoV at E3h in the upper and lower eyelids (P = 0.03 and P = 0.01, respectively). A progressive and significant reduction of the IRT values of LETG was also recorded in GLM, with differences in ERoV (35.2 °C ± 0.63) (P = 0.02) and E3h (35.3 °C ± 0.63) (P = 0.01). The cardiovascular parameters (SAP, DAP, and MAP) did not differ between treatments, but in GL, there was a significant difference (P = 0.01) during EInc and ESut, compared to Ebasal. In the body temperature, EInc and ESut gradually decreased in all treatment groups (P = 0.01). In conclusion, hemodynamic and cardiorespiratory stability was associated with IRT readings and the absence of nociception. Changes in superficial temperature in the immediate post-operative period were lessened using isoflurane and epidural analgesia of lidocaine alone or in combination with pure opioids. These findings were clinically validated to the DIVAS and UMPS acute pain assessment scales.

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“…The technique chosen in this study was based on the data observed in humans 12 and also on the difficulty of the tutor in adhering to the conservative treatment with oral anti-inflammatory because it is a herding dog whose dwelling in a rural area would interfere with the administration of the drug. Thus, electro stimulation-guided epidural administration combining dexamethasone (4mg) 13 , bupivacaine 0.125% (0.22mL. kg -1 ), and morphine (0.1mg.kg -1 ) 14 was the selected approach.…”

Section: Case Reportmentioning

confidence: 99%

“…Dexamethasone has been frequently used in analgesic blockades with the main advantage being its high potency and duration. In veterinary medicine, only one study reports the use of epidural dexamethasone 13 . This work evaluated the analgesic influence of different doses of dexamethasone (2, 4 and 8 mg) associated with lidocaine in dogs submitted to ovary salpingohisterectomy.…”

Section: 7mentioning

confidence: 99%

Interventional analgesic block in a dog with cauda equina syndrome. Case report

Mencalha¹,

Generoso²,

Souza³

2019

Brazilian Journal of Pain

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BACKGROUND AND OBJECTIVES: The cauda equina syndrome is a neurological condition prevalent in dogs which neurological signs are caused by the compression of the nerve roots located in the lumbosacral spinal canal and is frequently associated with pain, claudication, paresis or paralysis of the hindlimbs and changes in the functioning of the sphincters. The objective of this study was to check the effects of the epidural injection with the combination of dexamethasone, bupivacaine and morphine on the relief of pain and neurological signs in a dog with traumatic cauda equina syndrome. CASE REPORT: Case study of a 2-year old Red Heeler dog, weighing 16kg with a diagnosis of post-trauma cauda equina syndrome. The evaluation consisted of neurological and pain assessment (visual analog scale), quality of life ("5H2M") and infrared thermography. After the initial evaluation and authorization of the tutor, the dog was submitted to general anesthesia and a lumbosacral epidural block, guided by electrostimulation, with the association of dexamethasone, bupivacaine and morphine. After the procedure, the dog showed immediate remission of claudication, paresis and satisfactory analgesia on days 0, 15, 30 and 60 after the intervention. CONCLUSION: The epidural block was effective in improving pain, quality of life and neurological signs and may be an excellent alternative in dogs with pain syndromes associated with the spinal canal.

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The effect of epidurally administered dexamethasone with lignocaine for post-operative analgesia in dogs undergoing ovariohysterectomy. A dose-response study

Cited by 9 publications

References 30 publications

Analgesic effect of epidural maropitant and the combination of maropitant and lidocaine in cats subjected to ovariohysterectomy

Analgesic effect of epidural maropitant and the combination of maropitant and lidocaine in cats subjected to ovariohysterectomy

Assessment of thermal response, cardiorespiratory parameters and post-operative analgesia in dogs undergoing ovariohysterectomy with different combinations of epidural analgesia and isoflurane

Interventional analgesic block in a dog with cauda equina syndrome. Case report

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