The Effect of Equine Recombinant Growth Hormone on Second Intention Wound Healing in Horses

Abstract

Intramuscular administration of recombinant equine growth hormone (10 microg/kg daily for 7 days, then 20 microg/kg daily for 49 days) does not appear to have any beneficial clinical effect on healing of equine limb wounds.

Effect of activated protein C in second intention healing of equine distal limb wounds: a preliminary study

“…5,10 Digital photographs of the wounds were obtained on days 1, 7, 14, 21, 28, 35, 42 and 49 after wound creation and wounds were measured using image analysis software (Scion Image, Scion Corporation, USA) as previously described. 12,13,27 A 2.5 × 2.5 cm template (6.25 cm 2 ) was placed next to the wound as a standard reference. The area of the wound (cm 2 ) was measured three times and the average calculated to produce a single measure for each wound on each day.…”

Comparison of the effects of topical application of UMF20 and UMF5 manuka honey with a generic multifloral honey on wound healing variables in an uncontaminated surgical equine distal limb wound model

“…Most experimental studies of equine distal limb wound healing using surgical models have been performed on forelimbs. 43 The results of the present study suggested that in clean uncontaminated wounds of the distal limb in horses UMF20 is superior to both commercial food-grade multifloral honey and UMF5 as a topical treatment to enhance healing. 43 That study showed that hindlimb wounds healed significantly slower than forelimb wounds, but the pattern of healing is similar, with wounds initially retracting, followed by a period of consistent and steady contraction.…”

“…[28][29][30] Although UMF20 reduced the overall wound healing time compared with GH and the control, the healing times for all treatment groups were longer than those observed in previous studies of secondintention healing in forelimb wounds. 43 That study showed that hindlimb wounds healed significantly slower than forelimb wounds, but the pattern of healing is similar, with wounds initially retracting, followed by a period of consistent and steady contraction. [1][2][3][4][5][6][7][28][29][30][39][40][41][42] However, the prolonged healing times in this study are consistent with the results of the only other study to investigate distal limb wound healing in equine hindlimbs.…”

Recombinant equine growth hormone administration: effects on synovial fluid biomarkers and cartilage metabolism in horses

“…Recombinant equine growth hormone (reGH) has recently been evaluated for various applications in the horse (Malinowski et al 1997;McKeever et al 1998;Dart et al 2002). When administered s y s t e m i c a l l y, reGH increased plasma concentrations of IGF-1 and improved body condition in aged mares (Malinowski et al 1 9 9 7 ;McKeever et al 1998).…”