The effect of erythropoietin on healing of obstructive vs nonobstructive left colonic anastomosis: an experimental study

Moran, Münevver; Özmen, Mehmet Mahir; Düzgün, Arife Polat; Gok, Riza; Renda, Nurten; Seçkin, Selda; Çoşkun, Faruk

doi:10.1186/1749-7922-2-13

Cited by 17 publications

(14 citation statements)

References 32 publications

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“…Various agents have been investigated to ameliorate these effects of peritonitis on colonic anastomoses. All of these agents aiming to reduce ischemia including hyperbaric oxygen, glucan, erythropoietin, bosentan, growth hormone, and H 2 antagonists like famotidine [10][11][12][13][14][15] .…”

Section: Discussionmentioning

confidence: 99%

Effect of ozone on colon anastomoses in rat peritonitis model

et al. 2016

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PURPOSE:To investigate the effects of medical ozone theraphy on the colon anastomosis of peritonitis model in rats. METHODS:Eighteen rats were randomly assigned into three equal groups; control, cecal punctuation and colon anastomosis and ozone theraphy. Sepsis was performed with a cecal punctuation in groups 2 and 3. The medical ozone theraphy was administered intraperitonealy for three weeks in group 3 while the other rats received saline injection. At the twenty second day serum were obtained for TNF-α and IL-1β, the colonic burst pressures were measured and colonic tissue samples were obtained for MDA and MPO levels.Histolopatological examination was evaluated with H&E stain, and Ki-67, IL-1β and the VEGF immunostaining densities were also compared. RESULTS:Intraperitoneal ozone administration reversed TNF-α, IL-1β, MDA and MPO levels and the colonic burst pressures. There was also a significant difference at immunostaining densities of histopathological examination. CONCLUSION:Medical ozone therapy may contribute to tissue healing by affecting the proliferation and the vascularization thus has benefits on colonic anastomosis at peritonitis in rats.

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Section: Discussionmentioning

confidence: 99%

Effect of ozone on colon anastomoses in rat peritonitis model

et al. 2016

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“…These agents include hyperbaric oxygen, glucan, erythropoietin, bosentan, growth hormone, and H 2 antagonists like famotidine. All of these agents aim to reduce ischemia (18)(19)(20)(21)(22)(23). OT increases tissue oxygenation by shifting the oxyhaemoglobin curve to the right.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ozone Therapy (OT) on Healing of Colonic Anastomosis in a Rat Model of Peritonitis

Erginel¹,

Erginel²,

Aksoy³

et al. 2014

Balkan Med J

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Colonic resection and anastomosis is one of the most common operations in gastrointestinal surgery, both in children and adults. Although these are safe operations, an anastomosis leakage is a frequent problem (1, 2). Age, condition of the patient, colonic flora, inflammation and surgical techniques are the most important factors affecting the outcome of these procedures (3, 4). The presence of peritonitis is a defining factor of anastomosis integrity.The cecal ligation and puncture (CLP) model was first defined by Hubbard et al. (5) in 1978 to induce peritonitis. Several studies suggest that in the presence of peritonitis, wound healing worsens and anastomotic leakage increases. To avoid these unwanted effects of peritonitis on wound healing and to increase anastomosis security, various methods and local or systemic agents are being investigated.Ozone is a three-oxygen molecule (O 3 ). Ozone therapy (OT) is systematically effective when pathological inflammatory and immunologic processes are activated. Among these conditions are wound healing, macular degeneration related to aging, and conditions that are ischemic or infectious.During OT, the gaseous mixture of oxygen and ozone exerts biological actions that may increase certain enzymes and cytokines. Ozone provides its protective effects via autacoids, cytokines, and growth factors. Recurrent OT corrects the disBackground: Ozone is a three-oxygen molecule (O3). Ozone therapy (OT) is systematically effective when pathological inflammatory and immunologic processes are activated. Among of these conditions are wound healing, macular degeneration related to aging, and conditions that are ischemic or infectious. Aims: The aim of this study was to determine the effects of OT on wound healing of intestinal anastomosis in the presence of peritonitis in a rat model. Study Design: Animal experimentation. Methods: A total of 40 Wistar albino rats were randomized into four groups (n=10) including: sham (S), peritonitis (P), ozone 0 (O0), and ozone 24 (O24). In group S, only cecal dissection was carried out. The S group had only a cecal dissection and intestinal anastomosis performed, but no peritonitis. In all other groups, cecal ligation and puncture (CLP) followed the cecal dissection to induce bacterial peritonitis. 24 h after puncture, a cecal resection and ileocolic anastomosis were performed. In group P, 24 h after CLP, a cecal resection and ileocolic anastomosis were performed and no ozone was administered. In group O0, immediately after the anastomosis, and in group O24, starting 24 hours after the anastomosis, an intraperitoneal 1 mg/ kg/day ozone administration was applied for seven days. On the seventh day the animals were sacrificed, the anastomotic bursting pressures (BP) and the hydroxyproline values of the anastomotic tissues were measured, and histopathologic examination of the anastomotic segment was carried out. Results: The highest BP was in group S, with 211±23.13 mmHg. The mean BP of group P was 141±56.25 mmHg, which was significantly lower than in t...

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“…Although the incidence of this complication has been significantly reduced with the application of modern surgical techniques, it is still an important complication. [4,9,[12][13][14] As with all anastomoses, tissue blood flow and oxygenation are considerable factors in colonic anastomoses. [5,12] In comparison with other gastrointestinal components, the colon is known to present higher anastomotic leak rates due to its certain anatomical and biological characteristics, such as low collagen content, high collagenase activity, reduced collateral circulation, and absence of a serosa in the extraperitoneal rectum.…”

Section: Discussionmentioning

confidence: 99%

“…The common denominator of all those studies was the effort to reduce ischemia. [4,5,12,14,16,17] Benacerraf et al [18] reported 100% anastomotic leak in cases where perianastomotic oxygen pressure was below 20 mmHg, while denoting that the anastomotic leak rate was reduced by elevation of oxygen pressure. In the current study, we used pentoxifylline and vinpocetine to reduce ischemia.…”

Section: Discussionmentioning

confidence: 99%

İskemik kolon anastomozlarının iyileşmesi üzerine pentoxifylline ve vinpocetinenin etkisi. (Deneysel Çalışma)

Sümer¹

2011

Ulus Travma Acil Cerrahi Derg

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The effect of erythropoietin on healing of obstructive vs nonobstructive left colonic anastomosis: an experimental study

Abstract: We failed to find any direct and evident effects of erythropoietin on healing of left colonic anastomosis. On the other hand, erythropoietin might prevent negative effects of obstruction on healing.

Cited by 17 publications

References 32 publications

Effect of ozone on colon anastomoses in rat peritonitis model

Effect of ozone on colon anastomoses in rat peritonitis model

Effect of Ozone Therapy (OT) on Healing of Colonic Anastomosis in a Rat Model of Peritonitis

İskemik kolon anastomozlarının iyileşmesi üzerine pentoxifylline ve vinpocetinenin etkisi. (Deneysel Çalışma)

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