The effect of estrin and male hormone injected separately and simultaneously upon the smooth muscle and epithelium of the seminal vesicle in the albino rat

Overholser, M. D.; Nelson, Warren O.

doi:10.1002/ar.1090620304

Cited by 18 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The influence of sex hormones on the size and cellular appear ance of the seminal vesicle is well established from a lot of previous investigations (1,2,3,4,5,6,7,8,9,10,11,12,13,14).…”

Section: Les Vésicules Séminales Du Rat En Culture Tissulairementioning

confidence: 93%

Endocrine Dependence of Rat Seminal Vesicle Tissue in Tissue Culture

Bengmark¹,

Hesselsjoe²

1964

Urol Int

View full text Add to dashboard Cite

“…The influence of sex hormones on the size and cellular appear ance of the seminal vesicle is well established from a lot of previous investigations (1,2,3,4,5,6,7,8,9,10,11,12,13,14).…”

Section: Les Vésicules Séminales Du Rat En Culture Tissulairementioning

confidence: 93%

Endocrine Dependence of Rat Seminal Vesicle Tissue in Tissue Culture

Bengmark¹,

Hesselsjoe²

1964

Urol Int

View full text Add to dashboard Cite

“…picture is not seriously confused by them. On the contrary, it is specifically interesting to note that the hormone restored to some individuals the ejaculation pattern as well as the interest and ability to copulate, especially since secretory activity of the accessory sex glands is not restored by estrin administration (3,4,5,8,13,16). The castrate rat, however, although he has no secretion to ejaculate, nevertheless shows the behavior pattern typical of ejaculation in the normal male, differing in no observable detail from the complete normal pattern.…”

Section: Fig 2 Same As Figure 1 Second Gbotjp Of Testsmentioning

confidence: 99%

Sex activity of castrated male rats increased by estrin administration.

Ball¹

1937

Journal of Comparative Psychology

View full text Add to dashboard Cite

Nissen (12), using the obstruction box technique, has reported an increase of sex drive in castrated male rats after injection with placental extracts containing estrin. Kun (9) in a more direct study of mating behavior, reports that castrated male rats are changed so completely by estrin injections that they exhibit perfect female copulatory behavior. Nissen's report gives scanty information on the effect of estrin on actual copulatory behavior and Kun's results were hard to reconcile with the growing evidence (2,6,10,17) that sex behavior in the female is not brought about directly by the gonadal hormone but is more probably the result of some intermediate event set off by estrin. The following exploratory experiment undertook to examine the effect of estrin on male sex behavior more directly than Nissen's investigation and more quantitatively than Kun's. It was arranged on the basis of the assumption that estrin, if it did anything, would stimulate the pituitary 2 to release the same hormone the testes had released and thereby increase or restore normal sex activity. The results are not incompatible with this assumption as Kun's seem to be, but the two experiments are not 1 This investigation was supported by a grant from the Committee for Research in Problems of Sex, National Research Council.* Since the writing of this paper, there has come to my attention a report by Nelson and Gallagher (Science, 1936, 84, 230-232) that androgenic hormones alone enabled male rats to sire litters a month and more after the removal of the pituitary. The hypothesis that suggested the present experiment must, therefore, be incorrect. It is apparent that, although the results obtained are not incompatible with it, their explanation must be sought elsewhere.

show abstract

“…Unfortunately many have involved tissues other than the seminal vesicle (Kochakian, 1963;Coffey et al, 1968;Kerr & Searle, 1973;Lesser & Bruchovsky, 1973;Isotalo-& Santti, 1975) or species other than the rat (Deanesly-& Parkes, 1933;Ortiz et al, 1956;Allen, 1958;Kassenaar et al, 1962;Morley et al, 1973;Alison et al, 1974Alison et al, , 1976. Even where the seminal vesicle of the rat has been examined, these studies are not directly applicable to the problem under consideration, because the critical timeperiods were not examined in sufficient detail (Moore et al, 1930;Rabinovitch et al, 1951;Porter & Melampy, 1952;Ritter, 1969) or immature animals were used (Overholser & Nelson, 1935;Rudolph & Samuels, 1949;Sheppard et A!., 1965). The present study was undertaken in an attempt to define the action of testosterone on cell proliferation in the seminal vesicle of sexually mature rats.…”

mentioning

confidence: 99%

Testosterone control of nucleic acid content and proliferation of epithelium and stroma in rat seminal vesicles

Higgins

Burchell

Mainwaring

1976

Biochemical Journal

View full text Add to dashboard Cite

Tissue wet weight, nucleic acid content and epithelial and stromal cell numbers were measured in the seminal vesicles of sexually mature male rats. After castration, tissue weight and RNA decreased rapidly and in aprallel to reach, after 14 days, values only 15-20% of those in control (not castrated) animals. During this period, DNA decreased to a much lesser extent (by about 40%), but this change in DNA correlates well with the observed loss of cells from the epithelium. Testosterone in vivo promoted an immediate resynthesis of RNA, the value characteristic of control animals being reached within 80h. Delays occurred in the hormone-induced regain of tissue weight (30h) and DNA (40h), each of which preceded proliferation of the epithelium (40--50h). The cells of the stroma were unaffected by these changes in the androgenic statls of the animal. It is suggested that these proliferative changes in the epithelium cannot account for the previously reported induction by testosterone of basic secretory proteins in this tissue.

show abstract

The effect of estrin and male hormone injected separately and simultaneously upon the smooth muscle and epithelium of the seminal vesicle in the albino rat

Cited by 18 publications

References 7 publications

Endocrine Dependence of Rat Seminal Vesicle Tissue in Tissue Culture

Endocrine Dependence of Rat Seminal Vesicle Tissue in Tissue Culture

Sex activity of castrated male rats increased by estrin administration.

Testosterone control of nucleic acid content and proliferation of epithelium and stroma in rat seminal vesicles

Contact Info

Product

Resources

About