The Effect of Estrogen on Hepatic Fat Accumulation during Early Phase of Liver Regeneration after Partial Hepatectomy in Rats

Srisowanna, Naparee; Choijookhuu, Narantsog; Yano, Koichi; Batmunkh, Baatarsuren; Ikenoue, Makoto; Huynh, Nguyen Nhat; Yamaguchi, Yuya; Hishikawa, Yoshitaka

doi:10.1267/ahc.19018

Cited by 18 publications

(10 citation statements)

References 38 publications

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“…Estrogens, acting mainly through ERα, can limit liver damage by orchestrating cell proliferation, thus favoring liver regeneration, a process that further contributes to sex-differences in NAFLD progression, since male animals show higher recruitment of monocytes and a delayed recovery from acute liver injury [ 44 , 399 , 400 , 401 , 402 ]. Estrogen and ERα play an important role also in regulating the accumulation of fats in the liver by modulating CD36 during the early phase of liver regeneration, when FA, TG and CH are required for the proliferation of hepatocytes and for the formation of new cell membrane [ 403 ].…”

Section: Nafld and Estrogen Signalingmentioning

confidence: 99%

Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology

Torre

2021

Cells

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Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, being frequently associated with obesity, unbalanced dietary regimens, and reduced physical activity. Despite their greater adiposity and reduced physical activity, women show a lower risk of developing NAFLD in comparison to men, likely a consequence of a sex-specific regulation of liver metabolism. In the liver, sex differences in the uptake, synthesis, oxidation, deposition, and mobilization of lipids, as well as in the regulation of inflammation, are associated with differences in NAFLD prevalence and progression between men and women. Given the major role of sex hormones in driving hepatic sexual dimorphism, this review will focus on the role of sex hormones and their signaling in the regulation of hepatic metabolism and in the molecular mechanisms triggering NAFLD development and progression.

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Section: Nafld and Estrogen Signalingmentioning

confidence: 99%

Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology

Torre

2021

Cells

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“…One of the most important physiological changes in postmenopausal women is a dramatic reduction in estrogen. Estrogen deficiency promotes metabolic dysfunction that predisposes women to obesity, type 2 diabetes, and liver fat accumulation 17–19 . In our study, after adjusting for age, menopause duration, TG, and HDL‐C, a 1‐unit increase in the fat mass index was associated with a 0.176 U/L increase in ALT.…”

Section: Discussionmentioning

confidence: 51%

Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women

Wang

et al. 2022

Aging Medicine

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Objective To investigate the relationships between serum alanine aminotransferase (ALT) and body composition among postmenopausal women in China. Methods A cross‐sectional study was conducted with 776 postmenopausal women in China from May to July 2008. Clinical information was collected using a standardized questionnaire. Measures of body composition were obtained using dual X‐ray absorptiometry. Body lean mass and fat mass indices were calculated by dividing total body lean/fat weight (kg) by body height squared (kg/m2). Blood samples were collected to assess liver and renal functions and lipid profiles. Analysis of variance, Pearson correlations, and multiple regression were used to analyze the associations between serum ALT and body composition. Results We found negative relationships of serum ALT with age, menopause duration, and serum HDL‐C levels. Serum ALT was positively correlated with BMI, serum TG levels, and the lean mass index and fat mass index. In a multivariate model adjusted for age, menopause duration, serum TG, and HDL‐C levels, a 1‐unit increase in the fat mass index was associated with a 0.176 U/L increase in ALT (95% CI 0.020 to 0.050, P < 0.001). Conclusion Serum ALT was positively associated with the body fat mass index of postmenopausal women in China.

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“…Total RNA was extracted from snap frozen liver tissues using Isogen II (Nippon Gene, Tokyo, Japan), as reported previously 42 . RNA was reverse transcribed to cDNA using Moloney murine leukemia virus reverse transcriptase (Invitrogen, Carlsbad, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration

Yano

Choijookhuu

Ikenoue

et al. 2022

Sci Rep

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Liver regeneration is an extraordinarily complex process involving a variety of factors; however, the role of chromatin protein in hepatocyte proliferation is largely unknown. In this study, we investigated the functional role of high-mobility group box 2 (HMGB2), a chromatin protein in liver regeneration using wild-type and HMGB2-knockout (KO) mice. Liver tissues were sampled after 70% partial hepatectomy (PHx), and analyzed by immunohistochemistry, western blotting and flow cytometry using various markers of cell proliferation. In WT mice, hepatocyte proliferation was strongly correlated with the spatiotemporal expression of HMGB2; however, cell proliferation was significantly delayed in hepatocytes of HMGB2-KO mice. Quantitative PCR demonstrated that cyclin D1 and cyclin B1 mRNAs were significantly decreased in HMGB2-KO mice livers. Interestingly, hepatocyte size was significantly larger in HMGB2-KO mice at 36–72 h after PHx, and these results suggest that hepatocyte hypertrophy appeared in parallel with delayed cell proliferation. In vitro experiments demonstrated that cell proliferation was significantly decreased in HMGB2-KO cells. A significant delay in cell proliferation was also found in HMGB2-siRNA transfected cells. In summary, spatiotemporal expression of HMGB2 is important for regulation of hepatocyte proliferation and cell size during liver regeneration.

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The Effect of Estrogen on Hepatic Fat Accumulation during Early Phase of Liver Regeneration after Partial Hepatectomy in Rats

Cited by 18 publications

References 38 publications

Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology

Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology

Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women

Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration

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