The effect of ethane- l-hydroxy-1,1-diphosphonate (EHDP) on necrosis of atherosclerotic lesions

The effects of zoledronic acid on neointimal hyperplasia: a rabbit carotid anastomosis model

“…Accordingly, zoledronic acid, the most potent one in biphosphonates family was shown to inhibit tumor burden and prevent tumor cell metastasis (30). Furthermore, increasing studies have indicated that bisphosphonates could inhibit the development of experimental atherosclerosis (31,32) and neointimal hyperplasia (33,34). Although in most of the studies, biphosphonates have been shown to have inhibitory effects on MMPs in tumor growth and invasion (16,19), their possible inhibitory effects on intimal hyperplasia and MMPs remains unclear.…”

The Interleukin-6 inflammation pathway from cholesterol to aging – Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases

“…The authors concluded that etidronate in clinical dosage may have an antiatherogenic action, at least in type 2 diabetes [123]. In another study, administration of ethane-1-hydroxy-1,1-diphosphonate (EHDP) to swine with pre-established atherosclerosis resulted in lower lesion calcium concentration, smaller lesions and a decrease in the area of lesions involved in necrosis [124]. …”

Myocardial Infarction Risk Among Patients With Fractures Receiving Bisphosphonates

“…Bisphosphonates, which are used to treat and prevent osteoporosis, have been shown to have inhibitory effects on arterial calcification 19 and anti-atherogenic effects 20, 21 in animal models. Additionally, bisphosphonates have been associated with decreased prevalence of cardiovascular calcification in older women.…”