The Effect of Ethanol Extract <i>Mymercodia pendans</i> on Paracetamol-Induced Hepatotoxicity in White Rats

Merdana, I Made; Watiniasih, Ni Luh; Sudira, I Wayan; Samsuri,

doi:10.1088/1755-1315/248/1/012045

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…12 Liver injuries often exhibit various histopathological findings, including congestion, degeneration, and necrosis. 23 In our research, we observed several findings such as hepatic parenchyma degeneration, cellular degeneration, and necrotic areas in the histopathological examination of liver tissues. Similar outcomes were obtained in another study that evaluated the antiandrogenic effects of Propylparaben (PrP).…”

Section: Discussionmentioning

confidence: 60%

Investigation of the Combined Effects of Propylparaben and Methylparaben on Biochemical and Histological Parameters in Male Rats

İnkaya¹

2023

J Clin Pract Res

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Objective: This research aimed to study the effects of co-exposure to methylparaben and propylparaben (MeP+PrP) on renal and hepatic parameters in male rats. Materials and Methods: MeP and PrP were mixed at a ratio of 1:1. MeP+PrP doses were administered to 42-day-old male rats on a daily basis for 30 days. Each of the five groups consisted of six male rats, including three MeP+PrP dose groups with daily combination doses of 10 mg/kg bw, 100 mg/kg bw, and 500 mg/kg bw. The other two groups included the positive control group exposed to a daily dose of 50 mg/kg bw Bisphenol-A (BPA), and the corn oil control group used as a vehicle. At the end of the procedure period, liver and kidney tissues were obtained from histopathological analysis, morphometric analysis was performed on kidney tissue, and hematological and biochemical parameters were examined. Results: Histopathological changes, such as tubular degeneration, edema, fibrous tissue formation, and congestion, were observed in the kidney tissue, while degeneration, edema, and congestion were observed in the liver tissue. Statistical analysis comparing the administered groups to the corn oil control group revealed significant variations in biochemistry and hematological markers. Conclusion: These findings demonstrate that co-exposure to MeP and PrP alters biochemical and hematological parameters and negatively affects the liver and kidney tissues of male rats.

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Section: Discussionmentioning

confidence: 60%

Investigation of the Combined Effects of Propylparaben and Methylparaben on Biochemical and Histological Parameters in Male Rats

İnkaya¹

2023

J Clin Pract Res

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“…These compounds are very effective against free radicals, thereby protecting the kidneys from gentamicin-induced nephrotoxicity (Khalid et al 2011;Javaid et al 2012;Jaeschke et al 2012). Another study also showed the hepatoprotective ability of M. pendans, protecting rat liver from free radicals due to the induction of toxic doses of paracetamol (Merdana et al 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, there is important to explore the properties of these antioxidant compounds in eradicating free radicals' scavengers (Khalid et al 2011). Previous studies showed that its extract exhibited the ability as hepato-protector at a dose of 250 mg/kg/day in rats (Merdana et al 2019).…”

Section: Introductionmentioning

confidence: 95%

“…Also, it contains five types of flavonoids, namely: kaempferol, lutelin, routine, quercetin, and apigenin (Engida et al 2015). These active compounds are antioxidant (Wimpy, 2014), anticancerous (Soeksmanto et al 2010;Yap et al 2017), antibacterial (Gartika et al 2018), anti-inflammatory (Islamoyo et al 2018), immunomodulatory (Hertiani et al 2010), hepato-protector (Merdana et al 2019) in nature and also accelerate healing processes (Epsilawati et al 2019). Therefore, there is important to explore the properties of these antioxidant compounds in eradicating free radicals' scavengers (Khalid et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Ethanolic Extract of Myrmecodia pendans on Gentamicin Induced Nephrotoxicity in Wistar Rats

2021

Int J Vet Sci

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The purpose of the study was to investigate the nephroprotective effect of the Myrmecodia pendans extract on Wistar rats. The nephrotoxicity of the animals was induced through intra-peritoneal administration of 100mg/kg/day of gentamicin for ten days. The effect of M. pendans extract at a dose of 250mg/kg/day was concurrently monitored in some rats by assessing their serum creatinine levels, blood urea nitrogen (BUN) and the histopathological parameters. The mean of serum creatinine in control group was 1.17±0.18mg/dl and in nephrotoxic group it was 2.22±0.29 mg/dl, while in group given the extract were 1.38±0.19 and 1.27±0.15mg/dl, respectively. In that group also sequentially showed BUN levels of 24.27±2.6, 108.13±11.58, 30.70±4.23 and 27.28±2.84mg/dl, respectively. Nephrotoxicity was induced in the animals injected with gentamicin, which showed a significant (P<0.05) increase in creatinine and BUN compared with control group. The results also showed that the M. pendans ethanolic extracts significantly (P<0.05) prevented the increase in the levels of serum creatinine, BUN and reduced renal histopathological damage such as hydropic degeneration, vascular congestion and tubular necrosis. Therefore, the ethanolic extract of M. pendans exhibits a nephroprotective activity.

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Liver Histopathological Change and Malondialdehyde Level of Rattus Norvegicus on Administration of Curcuma Zedoaria and Paracetamol Toxic Dose

Tania

Misuari

Yudhayana

et al. 2021

IJMLST

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High doses of paracetamol create necrosis in the liver and produce free radicals. When liver function decreased in a long time, it will lead to severe liver damage and it will be irreversible. Rhizome of Curcuma zedoaria has the potential effect as an antioxidant, it is assumed that its properties inhibit the formation of free radicals which formed from toxic doses of paracetamol. The aim of this study was to examine the histological structure of the liver and to determine MDA levels in the administration of C. zedoaria toxic dose and paracetamol on the Rattus norvegicus. The study was used twenty-four rats divided into four groups (positive control: CMC 0.5%; negative control: paracetamol 1.35g/kg body weight; treatment group 1 (T1): C. zedoaria 105 mg/200g and paracetamol 1.35g/kg Body weight 2 hours later, and treatment group 2 (T2): paracetamol 1.35g/ kg Body weight and C. zedoaria 105 mg/200g 2 hours later). The Kruskall-Wallis test results showed MDA level did not significantly different between groups (p = 0.087). Hepatocellular changes were observed descriptively with Hematoxylin-eosin staining. Positive control showed greater hepatocellular changes rather than other groups, hepatocyte cells were enlarged with cytoplasm showing eosinophilic granules infiltrates, enlarged irregular nuclei, nucleolus prominent, there are many necrosis cells.

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The Effect of Ethanol Extract Mymercodia pendans on Paracetamol-Induced Hepatotoxicity in White Rats

Cited by 3 publications

References 16 publications

Investigation of the Combined Effects of Propylparaben and Methylparaben on Biochemical and Histological Parameters in Male Rats

Investigation of the Combined Effects of Propylparaben and Methylparaben on Biochemical and Histological Parameters in Male Rats

The Effect of Ethanolic Extract of Myrmecodia pendans on Gentamicin Induced Nephrotoxicity in Wistar Rats

Liver Histopathological Change and Malondialdehyde Level of Rattus Norvegicus on Administration of Curcuma Zedoaria and Paracetamol Toxic Dose

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