The effect of ethanol intake on tendon healing: a histological and biomechanical study in a rat model

Hapa, Onur; Çakıcı, Hüsamettin; Gideroğlu, Kaan; Özturan, Kutay Engin; Kükner, Aysel; Buğdaycı, Güler

doi:10.1007/s00402-009-0877-x

Cited by 24 publications

(22 citation statements)

References 20 publications

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“…One standard drink daily was associated with a 52% increased hospitalization risk. Alcohol has potential direct toxic effects on tendons through inhibition of fibroblast proliferation and collagen synthesis , but may also adversely affect the associated musculature leading to joint destabilization and an increased risk of mechanical injury . Similarly, and consistent with the 5% increased frequency of hospitalization for tendon rupture for each 1 kg/m 2 BMI increase in our cohort with diabetes, there is evidence that adiposity increases the risk of tendon rupture through systemic effects (e.g.…”

Section: Discussionmentioning

confidence: 99%

Incidence and predictors of hospitalization for tendon rupture in Type 2 diabetes: the Fremantle Diabetes Study

Zakaria

Davis

2013

Diabet. Med.

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Section: Discussionmentioning

confidence: 99%

Incidence and predictors of hospitalization for tendon rupture in Type 2 diabetes: the Fremantle Diabetes Study

Zakaria

Davis

2013

Diabet. Med.

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“…The main findings were that the laser-treated animals showed positive effects on the process of tissue repair and produced greater MyoD, myogenin, and VEGF immunoexpression compared to the untreated group (AI). It is known that chronic alcohol consumption leads to progressive alterations in the musculoskeletal system, such as muscle atrophy and decreased skeletal muscle repair 16 . This process may be related to alcohol-induced apoptosis of skeletal muscle, suppressed release of proinflammatory cytokines, diminished neutrophil recruitment, and altered phagocytic and chemotactic functions 16,17 .…”

Section: Discussionmentioning

confidence: 99%

“…It is known that chronic alcohol consumption leads to progressive alterations in the musculoskeletal system, such as muscle atrophy and decreased skeletal muscle repair 16 . This process may be related to alcohol-induced apoptosis of skeletal muscle, suppressed release of proinflammatory cytokines, diminished neutrophil recruitment, and altered phagocytic and chemotactic functions 16,17 . The dose and timing of ethanol exposure can induce variable effects on immune function and on organ tissues.…”

Section: Discussionmentioning

confidence: 99%

Effects of Low-level Laser Therapy on Muscle Repair in Rats with Chronic Alcohol Intake

Céspedes

Assis

Thomaz

et al. 2018

Braz. arch. biol. technol.

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This study aimed to investigate the effects of low-level laser therapy (LLLT) on muscle repair in rats with chronic alcohol intake. Thirty male Wistar rats were distributed into three groups: injured tibialis anterior (TA) muscle without treatment (IC); chronic ingestion of alcohol plus injured TA muscle (AI); and chronic ingestion of alcohol plus injured TA plus LLLT (AIL). Each group was divided into two different subgroups, and rats were sacrificed on days 3 and 7 post-injury. Morphological features in the injured areas were similar with or without alcohol intake (IC and AI); however, LLLT promoted a decrease in the number of inflammatory cells and destroyed zones, as well as improved tissue organization (AIL). In general, alcohol intake caused a decrease in myogenic regulatory factors (MyoD and myogenin) and vascular endothelial growth factor in the AI group. Moreover, LLLT promoted recovery of these factors to the same level as in animals without alcohol intake (IC and AIL). LLLT was able to increase the expression of myogenic and vascular growth factors and stimulate skeletal muscle regeneration in rats with chronic alcohol intake.

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“…Fibroblasts produce and secrete procollagen, which is hydroxilated and glycosilated to form a triple helix configuration. The triple helix bundles cross-link to form the three-dimensional structure and the synthesized collagen fibers are organized and gain a mature structure in the remodeling phase [14].…”

Section: Discussionmentioning

confidence: 99%

The Biomechanical and Histological Effects of Diabetes on Tendon Healing: Experimental Study in Rats

et al. 2016

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The aim of this study was to investigate the biomechanical and histological perspectives of healing of Achilles tendon in diabetic rats and compare the results with non-diabetic subjects. Fifty four adult Wistar Albino rats weighing 300-350 g were used throughout the study. Six animals were excluded from the study and replaced. Rats were randomly assigned to either the experimental or the control group comprised of 24 rats in each. Diabetes was induced in experimental group with streptozotocin. 3 days after the induction of diabetes, both Achilles tendons were transected 5 mm proximal to their insertions to the calcaneal bone and repaired by using 6/0 polypropylene sutures with modified Kessler method. At weeks 2, 4 and 6, eight rats from each group were euthanized. Left Achilles tendons including the repair site were prepared for histological evaluation and right legs were prepared for mechanical testing. When compared to control group, diabetic animals displayed a lower peak force for failure in each of the second, fourth and sixth week. The differences between the groups in each week were found to be significant in statistical assessments (p<0.05). Histologic assessment revealed that the diabetic animals had significantly less amount of fibroblast proliferation and lymphocyte infiltration compared to the control group. There is significant delay in tendon strength at the end of week 2, 4 and 6 postoperatively in the diabetic rats. Therefore diabetic individuals require specific postoperative follow up and rehabilitation procedures.

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The effect of ethanol intake on tendon healing: a histological and biomechanical study in a rat model

Cited by 24 publications

References 20 publications

Incidence and predictors of hospitalization for tendon rupture in Type 2 diabetes: the Fremantle Diabetes Study

Incidence and predictors of hospitalization for tendon rupture in Type 2 diabetes: the Fremantle Diabetes Study

Effects of Low-level Laser Therapy on Muscle Repair in Rats with Chronic Alcohol Intake

The Biomechanical and Histological Effects of Diabetes on Tendon Healing: Experimental Study in Rats

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