The Effect of Ethanolic Extract of Justicia Secunda on Kidney Function in Female Wistar Rats

Abstract

Purpose: The kidneys serve as the excretory organ of the body. The assessment of serum creatinine, urea, and electrolytes (Na+, K+, HCO3-, Cl-) are crucial and sensitive biochemical markers that are usually involved in the diagnosis of renal impairments (Agbasi et al. 2010; Tietz, 2008; Yakubu et al. 2003).
 Methodology: Thirty-six animals were grouped into 6, with 6 rats in each group. The animals were housed at room temperature in metal cages. Animals in each group had access to clean water and commercial standard rodent pellets. Group 1 (control group) received distilled water, Groups 2-6 were treated orally with low, middle, and high doses of ethanolic extract of Justicia secunda leaves daily for 42 days.
 Findings: A significant increase in the level of urea concentration was observed compared to the control. From the present study, Na+, K+, Cl-, and HCO3 increased significantly in the moderate and high dose groups.
 Unique contribution to theory, policy and practice: In conclusion, this study indicates that ethanolic extract of Justicia secunda increased the serum level of urea, creatinine, and electrolytes.

Sexual Invigorating Potentials of a Combined Extract of Sabicea calycina and Carpolobia lutea on Male Wistar Rats in Crude Oil Challenged Environment

“…This is the time interlude between the introduction of the female to the first mount by the male [20,54]. A mount is when the male rat straddles the female from the back and clasps her flanks with his front feet.…”