The effect of ethnic origin on nuchal translucency at 10–14 weeks of gestation

Chen, Min; Lam, Yung Hang; Tang, Mary Hoi Yin; Lee, Chin Peng; Sin, Sai Yuen; Tang, Rebecca; Wong, H. S.; Wong, Sai Fun

doi:10.1002/pd.363

Cited by 54 publications

(30 citation statements)

References 16 publications

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“…The 95th percentile NT thickness at a CRL between 75 and <85 mm (2.10 mm) was thinner than the accepted fixed cut-off point (≥2.5 mm). Several studies have reported significant differences in NT thickness measurements among ethnic groups [6,7,8]; however, this was clinically insignificant, as only a small proportion of DS fetuses had an NT thickness at 95th percentile values. A reason for the differences between our study and these earlier ones could be that to acquire the NT measurement, we used the average from three measurements instead of the largest measurement.…”

Section: Discussionmentioning

confidence: 99%

“…This variation could be explained by several factors such as study design, NT cut-off value, gestational age at measurement, selection bias, verification bias, and operator’s experience. Recent studies [6,7,8] have also suggested that there may be significant differences in NT measurements among fetuses of different ethnic origins. This finding may have a potential impact on the screening efficacy of NT, suggesting that, in screening for chromosomal defects, the use of a single cut-off value for fetal NT may be inappropriate [9].…”

Section: Introductionmentioning

confidence: 99%

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Distribution of Normal Nuchal Translucency Thickness: A Multicenter Study in Thailand

Kor-anantakul

Suntharasaj

Suwanrath

et al. 2010

Gynecol Obstet Invest

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Aims: To establish the normative data distribution of nuchal translucency (NT) thickness in Thai fetuses. Methods: A cross-sectional multicenter study was conducted among 6,455 women with singleton pregnancies and gestational age between 10 and 14 weeks. For each case, the fetal crown-rump length (CRL) and NT were measured by transabdominal ultrasound. Transvaginal ultrasounds were used in poorly visualized cases. The distribution values of the NT thicknesses and their corresponding 10-mm CRL intervals between 45 and 84 mm were examined to obtain the median and 95th percentiles. Quantile regression modeling across the CRLs was performed to obtain the reference values. Results: Transabdominal ultrasound measurements were successfully done on 6,347 fetuses with 39 cases by the transvaginal route. Fetuses with CRL between 45 and 84 mm and normal outcomes made up a total of 4,352 cases. The mean (SD) gestational age, CRL and NT thickness were 12.5 (0.7) weeks, 60.2 (9.7) mm, and 1.15 (0.38) mm, respectively. The mean normal NT increased linearly with CRL. The quantile regression equation to predict the 95th percentile of the NT thickness (mm) was 0.727 + [0.017 × CRL (mm)]. Conclusions: The NT thickness in normal Thai fetuses was found to be thinner than in both Caucasian and other Asian populations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distribution of Normal Nuchal Translucency Thickness: A Multicenter Study in Thailand

Kor-anantakul

Suntharasaj

Suwanrath

et al. 2010

Gynecol Obstet Invest

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“…Within a few years, the Danish Fetal Database, which started to collect data on all Danish pregnancies from January 1, 2008, will allow further investigations on the topic [16] . Maternal ethnic origin is known to affect NT [17][18][19] , but we did not adjust for this factor, since the Danish population is mainly Caucasian [20] and only Danish-speaking women were invited to participate in the study (approximately 96% of the participants in the study were Caucasian). In addition, Spencer et al [19] found that average weight and frequency of smokers differed between ethnic groups, and concluded that this may contribute to the observed association between ethnicity and NT.…”

Section: Discussionmentioning

confidence: 99%

Maternal Smoking, Obesity and Male Fetal Sex Predispose to a Large Nuchal Translucency Thickness in Healthy Fetuses

et al. 2010

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Objectives: Our aim was to evaluate the effect of fetal sex, smoking and body mass index (BMI) on nuchal translucency (NT). Methods: We analyzed data from 7,357 women with a normal singleton live birth outcome with information on smoking, BMI and sex of the infant. NT measurements were converted to multiples of the median (MoM_NT) using a previously reported linear regression analysis. Results: The odds ratio (OR) for MoM_NT >95th centile was 1.5 (95% CI 1.2–1.9) for smokers compared to nonsmokers and 1.4 (95% CI 1.1–1.7) for male fetuses compared to female fetuses. Obese women (BMI ≧30) had an increased OR for a large NT of 1.7 (95% CI 1.2–2.6) compared to normal weight women. Obese smokers carrying a male fetus had an OR of 4.2 (95% CI 1.7–10.1) of a MoM_NT >95th centile compared to normal weight nonsmoking women with a female fetus. The effects of smoking, obesity status and fetal sex were independent of each other. Conclusions: Smoking, obesity and male sex are associated to a MoM_NT >95th centile. This may affect screening performance and entail unnecessary anxiety in these women. Further investigations, including fetuses with adverse outcome, are needed.

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“…It is well known the need to correct biochemical markers, such as the free fraction of β-HCG and pregnancyassociated plasma protein-A (PAPP-A), in addition to ultrasound markers, like NT measurement in the first trimester for Down syndrome, in different ethnical groups [3].…”

Section: Introductionmentioning

confidence: 99%

Reference values of nuchal translucency thickness in a Brazilian population sample: experience from a single center

Júnior¹,

Pires²,

Martins³

et al. 2013

Journal of Perinatal Medicine

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The effect of ethnic origin on nuchal translucency at 10–14 weeks of gestation

Abstract: Although there were statistically significant differences in NT measurements between different ethnic groups, it was clinically insignificant, as reflected by similar screen-positive rates.

Cited by 54 publications

References 16 publications

Distribution of Normal Nuchal Translucency Thickness: A Multicenter Study in Thailand

Distribution of Normal Nuchal Translucency Thickness: A Multicenter Study in Thailand

Maternal Smoking, Obesity and Male Fetal Sex Predispose to a Large Nuchal Translucency Thickness in Healthy Fetuses

Reference values of nuchal translucency thickness in a Brazilian population sample: experience from a single center

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