2016
DOI: 10.1016/j.ajem.2016.06.003
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The effect of ethyl pyruvate and N-acetylcysteine on ischemia-reperfusion injury in an experimental model of ischemic stroke

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Cited by 30 publications
(20 citation statements)
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“…In various animal models of critical illness treatment with EP has been shown to improve survival and/or amelioration of organ dysfunction, e.g. I/R injury in stroke [ 16 , 36 ], I/R injury in an electrical burn model [ 37 ], brain injury [ 38 ], myocardial I/R injury [ 39 ], and whole body radiation-induced injury [ 40 ]. Anti-inflammatory and anti-oxidative action of EP has also been observed in models using human cells, e.g., in cultured Caco-2 transformed human intestinal epithelial cells [ 41 ], in HUVECs [ 42 ], in A549 human transformed pulmonary epithelial cells [ 43 ], and in A549 human alveolar epithelial cells [ 44 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In various animal models of critical illness treatment with EP has been shown to improve survival and/or amelioration of organ dysfunction, e.g. I/R injury in stroke [ 16 , 36 ], I/R injury in an electrical burn model [ 37 ], brain injury [ 38 ], myocardial I/R injury [ 39 ], and whole body radiation-induced injury [ 40 ]. Anti-inflammatory and anti-oxidative action of EP has also been observed in models using human cells, e.g., in cultured Caco-2 transformed human intestinal epithelial cells [ 41 ], in HUVECs [ 42 ], in A549 human transformed pulmonary epithelial cells [ 43 ], and in A549 human alveolar epithelial cells [ 44 ].…”
Section: Discussionmentioning
confidence: 99%
“…This reaction mixture, diluted derivatized standard solutions (0.625–10.000 nmol/mL), and reagent blanks were injected into the HPLC system (injection volume: 40 μL). The MDA standard was prepared as previously described [ 16 ]. The DNPH derivatives (hydrazones) were separated isocratically on a 5 μm ODS hypersil column (150 x 4.6 mm) guarded by a 5 μm ODS hypersil column (10 x 4.6 mm; Uniguard holder; Thermo Electron Corporation, Cheshire, UK) with a mobile phase consisting of a 0.2% (v/v) acetic acid solution (bidistilled water) containing 50% acetonitrile (v/v).…”
Section: Methodsmentioning
confidence: 99%
“…NAC and EP were administered intraperitoneally after ischemia. A lower percentage of degenerative neurons was observed in rats receiving NAC or EP compared to the I/R group, which indicates that NAC shows neuroprotective efficacy [134]. Sekhon et al have studied the therapeutic effectiveness of NAC to reduce the ischemia-reperfusion injury in brain tissue generated by a focal cerebral ischemia model in rats.…”
Section: Nac In Strokementioning
confidence: 99%
“…Ethyl pyruvate, a ROS scavenger, has been found to ameliorate in different conditions such as sepsis, acute pancreatitis, burn, radiation injury and hemorrhagic shock[98,99]. Turkmen et al[100] reported that ethyl pyruvate has a positive effect on torsion-detorsion associated I/R injury in an experimental rat model.…”
Section: Searchmentioning
confidence: 99%