The effect of etomidate induction on plasma cortisol levels in children undergoing cardiac surgery

The Effect of Etomidate on Intracranial Pressure and Systemic Blood Pressure in Pediatric Patients with Severe Traumatic Brain Injury

“…17,18 Whereas a decrease in plasma cortisol production has also been reported after single dose administration of etomidate, this effect seems to be transient and has not been associated with any clinical signs of adrenal insufficiency or increased mortality. 1,19 A decrease in adrenocorticotropic (ACTH) hormone -stimulated cortisol production was also found after single-dose etomidate in critically ill adults without any discernable effect on morbidity and mortality. 1 Others have shown no effect of single-dose etomidate on adrenal function.…”

Adrenocortical response in infants undergoing cardiac surgery with cardiopulmonary bypass and circulatory arrest*

“…However, standard anesthetic management of the age group included in this study consisted of a balanced technique including the use of an opioid infusion (generally morphine), isoflurane, and pancuronium with the addition of lorazepam during CPB. Anesthetic agents such as etomidate and isoflurane have been shown to decrease the cortisol response during CPB, (11,12) but etomidate was not used as an induction agent in our patients, and the uniform use isoflurane should have minimized any effects it might have had on cortisol responses among groups.…”

Fonction surrénalienne après bolus d’étomidate en chirurgie cardiaque : une étude rétrospective

“…Dans le contexte d'une administration d'hypnotiques et de sédatifs morphiniques, la responsabilité de l'étomidate dans la survenue d'une insuffisance surrénalienne d'origine médicamenteuse semble plausible [12]. La seule étude ayant documenté les effets endocriniens d'une dose d'étomidate chez des patients non sélectionnés candidats à une chirurgie cardiaque a été réalisée chez des enfants [14]. Ce travail a conclu quel' étomidate altère la fonction surrénalienne au cours de la période postopératoire sans en décrire les éventuelles conséquences.…”