The effect of evening primrose oil on labor induction and cervical ripening: A systematic review and <scp>meta‐analysis</scp>

Moradi, Maryam; Niazi, Azin; Miri, Hamid Heidarian; Lopez, Violeta

doi:10.1002/ptr.7147

Cited by 15 publications

(17 citation statements)

References 27 publications

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“…The results of a meta-analysis by Moradi et al . [ 19 ] showed no significant difference in Bishop Scores before and after in the intervention and control groups. Based on the current meta-analysis of four studies, the effectiveness of oral consumption of evening primrose on cervical maturation was not confirmed.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of the Effect of Vaginal Use of Primrose Oil with Misoprostol on Cervical Preparation of Prim Gravid Women: A Double-Blind Clinical Trial

Shahraki

Mirhoseini

Movahedi

et al. 2023

Advanced Biomedical Research

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Background: This study compares the effect of vaginal administration of evening primrose oil with misoprostol on cervical preparation in prim gravid women at ≥40 weeks gestation. Materials and Methods: This was a double-blind randomized clinical trial conducted in Isfahan, Iran during 2019-2020 on 110 prim gravid pregnant women with a gestational age of 40 weeks and more and cephalic presentation of the fetus with the obstetrical indication for pregnancy termination. After obstetric examinations to rule out cephalo pelvic disproportion and calculation of the Bishop score by the researcher, patients were randomized to receive 25 μg misoprostol tablets ( n = 55) or 1000 mg evening primrose oil Pearls ( n = 55) administrated vaginally by a midwife. We compared Bishop's score before and after the intervention, time of cervical ripening, a dose of intervention for cervical ripening, need to induce labor, the interval between cervical preparation and induction of labor, duration of oxytocin use, need for cesarean section, and its cause, Apgar score at 5 and 10 minutes, neonatal birth weight. Results: Mean baseline Bishop Score was not significant between the groups ( P = 0.45); after the intervention, it was significantly higher in the primrose oil group ( P < .001). Significantly fewer patients required cesarean sections in the primrose oil group ( P = 0.03). The other outcomes were. not significant between the groups ( P > 0.05). Conclusion: Misoprostol and primrose oil administration appear to positively affect cervical readiness. Primrose oil resulted in significantly better Bishop Scores and fewer cesarean sections compared to misoprostol in pregnancy 40 weeks and more.

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Section: Discussionmentioning

confidence: 99%

Comparative Study of the Effect of Vaginal Use of Primrose Oil with Misoprostol on Cervical Preparation of Prim Gravid Women: A Double-Blind Clinical Trial

Shahraki

Mirhoseini

Movahedi

et al. 2023

Advanced Biomedical Research

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“…Usually in first pregnancy, the effect of primrose oil capsules taken orally and their effect on cervix in terms of bishop score are determined in 38 to 42 weeks of gestation. 23 Researchers described effective results of oil through vaginal insertion. 24 Further studies are required to see the effect of vaginal insertion.…”

Section: Discussionmentioning

confidence: 99%

An assessment of cervical ripening with evening primrose oil: An obstetrical review

Masood¹,

Ali²,

Imtiaz³

et al. 2022

TPMJ

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Objective: To compare cervical ripening in women having evening primrose oil with those not taking it. Study Design: Retrospective Cohort study. Setting: Department of Obs & Gynae, Abbasi Shaheed Hospital, Karachi. Period: July 2018 to April 2021. Material & Method: Patients were divided into 2 groups, one having evening primrose oil (EPO) 1gm twice daily from 37 weeks till labor, given by her previous birth attendant. Another group was without using evening primrose oil. Both were examined for cervical ripening by bishop score, length of labour and then for need for cesarean section. Statistical plan: SPSS 20. Results: BISHOP score for EPO group (6.1) vs non-EPO group (4.3) was statistically significant (p-value < 0.001). EPO have soft cervical consistency (73.5%), followed by medium (10.2%) and firm (16.3%) while non EPO have firm consistency (41.2%) followed by soft (37.3%) and medium (21.6%). The differences was statistically significant (p-value=0.001). The average length of labor for EPO group was 7.7 hours (±2.5 SD) and Non-EPO was 8.4 hours (±2.4 SD), statistically insignificant. The mode of delivery wasn’t statistically significantly different between two groups. Conclusion: EPO tend to have soft cervical consistency. However mode of delivery between EPO group and Non-EPO group did not have any significant difference.

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“…However, a later systematic review and meta-analysis of 4 trials favored vaginal dosing by demonstrating no difference in Bishop scores with oral consumption of evening primrose oil on cervical ripening. 10 Given the heterogeneity of studies in both these meta-analyses, further research is recommended to further explore the efficacy of evening primrose oil on cervical ripening. However, given the current data, which demonstrate no adverse effects, we can conclude that vaginal administration would be favored over oral administration.…”

Section: Nonpharmaceutical Methodsmentioning

confidence: 99%

“…This meta-analysis describes daily dosing of 1000-mg primrose oil capsules orally or vaginally, ranging from once near time of delivery to daily from the 38th week of pregnancy until time of delivery. However, a later systematic review and meta-analysis of 4 trials favored vaginal dosing by demonstrating no difference in Bishop scores with oral consumption of evening primrose oil on cervical ripening 10 . Given the heterogeneity of studies in both these meta-analyses, further research is recommended to further explore the efficacy of evening primrose oil on cervical ripening.…”

Section: Prior To Inductionmentioning

confidence: 99%

Evidence Based Management of Labor

Zambrano Guevara,

Buckheit,

Kuller

et al. 2024

Obstetrical &Amp; Gynecological Survey

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Importance Induction of labor (IOL) is a common obstetric intervention. Augmentation of labor and active management of the second stage is frequently required in obstetric practice. However, techniques around labor and induction management vary widely. Evidence-based practice regarding induction and labor management can reduce birth complications such as infection and hemorrhage and decrease rates of cesarean delivery. Objective To review existing evidence on IOL and labor management strategies with respect to preparing for induction, cervical ripening, induction and augmentation, and second stage of labor techniques. Evidence acquisition Review of recent original research, review articles, and guidelines on IOL using PubMed (2000–2022). Results Preinduction, pelvic floor training and perineal massage reduce postpartum urinary incontinence and perineal trauma, respectively. Timely membrane sweeping (38 weeks) can promote spontaneous labor and prevent postterm inductions. Outpatient Foley bulb placement in low-risk nulliparous patients with planned IOL reduces time to delivery. Inpatient Foley bulb use beyond 6 to 12 hours shows no benefit. When synthetic prostaglandins are indicated, vaginal misoprostol should be preferred. For nulliparous patients and those with obesity, oxytocin should be titrated using a high-dose protocol. Once cervical dilation is complete, pushing should begin immediately. Warm compresses and perineal massage decrease risk of perineal trauma. Conclusion and relevance Several strategies exist to assist in successful IOL and promote vaginal delivery. Evidence-based strategies should be used to improve outcomes and decrease risk of complications and cesarean delivery. Recommendations should be shared across interdisciplinary team members, creating a model that promotes safe patient care. Target Audience Obstetricians and gynecologists, family physicians Learning Objectives Discuss the current evidence and best practices regarding prelabor interventions to improve delivery outcomes; describe evidence-based methods of cervical ripening; outline data-driven practices to progress induction; and explain methods to improve birth outcomes and reduce risks in the second stage of labor.

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The effect of evening primrose oil on labor induction and cervical ripening: A systematic review and meta‐analysis

Cited by 15 publications

References 27 publications

Comparative Study of the Effect of Vaginal Use of Primrose Oil with Misoprostol on Cervical Preparation of Prim Gravid Women: A Double-Blind Clinical Trial

Comparative Study of the Effect of Vaginal Use of Primrose Oil with Misoprostol on Cervical Preparation of Prim Gravid Women: A Double-Blind Clinical Trial

An assessment of cervical ripening with evening primrose oil: An obstetrical review

Evidence Based Management of Labor

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