The effect of exercise and nettle supplementation on oxidative stress markers in the rat brain

Toldy, Anna; Stadler, Krisztián; Sasvári, Mária; Jakus, Judit; Jung, Kyung Jin; Chung, Hae Young; Berkes, István; Nyakas, Csaba; Radák, Zsolt

doi:10.1016/j.brainresbull.2005.02.028

Cited by 91 publications

(43 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nettle is reported to have medical (Viegi et al, 2003), antioxidative (Toldy et al, 2005) and growth-stimulating (Krusiński, 2004) properties. It is hypothesized that it may also affect protein and lipid metabolism and improve the quality of pig products.…”

Section: Introductionmentioning

confidence: 99%

The effect of nettle (<i>Urtica dioica</i>) extract on fattening performance and fatty acid profile in the meat and serum lipids of pigs

Szewczyk¹,

Hańczakowska²,

Witkiewicz³

2006

J. Anim. Feed Sci.

View full text Add to dashboard Cite

From a body weight of 60 to 112 kg, forty-two pigs were fed a standard diet that was either not supplemented (control) or supplemented with a dried water extract of nettle (NE) at a rate of 500 (group LN) or 1000 mg/kg (group HN). Protein deposition was greater in LN than in HN or control pigs. The higher level of NE resulted in decreased body weight gains and increased loin eye area. NE induced changes in the fatty acid profile of meat, but in the blood, it failed to affect the total cholesterol (TC) concentration , while decreasing the HDL level and TC/HDL ratio.

show abstract

Section: Introductionmentioning

confidence: 99%

The effect of nettle (<i>Urtica dioica</i>) extract on fattening performance and fatty acid profile in the meat and serum lipids of pigs

Szewczyk¹,

Hańczakowska²,

Witkiewicz³

2006

J. Anim. Feed Sci.

View full text Add to dashboard Cite

show abstract

“…Studies have shown that synergistic effects of exercise and dietary supplementation have positive effects by attenuating the oxidative stress in the aging rat brain [16,17]. Therefore, the present study was hypothesized to investigate the combined effects of exercise and Dh supplementation in curtailing oxidative stress in the aging rat brain.…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise

et al. 2016

View full text Add to dashboard Cite

The synergistic effects of physical exercise and diet have profound benefits on brain function. The present study was aimed to determine the effects of exercise and Decalepis hamiltonii (Dh) on age-related responses on the antioxidant status in discrete regions of rat brain. Male Wistar albino rats of 4 and 18 months old were orally supplemented with Dh extract and swim trained at 3 % intensity for 30 min/day, 5 days/ week, for a period of 30 days. Supplementation of 100 mg Dh aqueous extract/kg body weight and its combination with exercise significantly elevated the antioxidant enzyme activities irrespective of age. Age-related and region-specific changes were observed in superoxide levels, and protein carbonyl and malondialdehyde contents, and were found to be decreased in both trained and supplemented groups. Levels of total thiols, protein, and nonprotein thiols decreased with age and significantly increased in the SW-T(?100 mg) groups. Our results demonstrated that the interactive effects of two treatments enhanced the antioxidant status and decreased the risk of protein and lipid oxidation in the rat brain.

show abstract

“…17 The level of oxidative protein damage, assessed by reactive carbonyl derivatives, was not changed as a result of regular exercise and oxidant and antioxidant treatment. Toldy et al 18 have similarly reported no effect of regular exercise on brain reactive carbonyl derivatives. 4 and linked to ameliorative function.…”

Section: Discussionmentioning

confidence: 96%

The effect of exercise and oxidant–antioxidant intervention on the levels of neurotrophins and free radicals in spinal cord of rats

et al. 2008

View full text Add to dashboard Cite

Study design: This study was designed to investigate the effects of oxidant and antioxidant treatment, as well as regular exercise, on neurotrophin levels in the spinal cord of rats. Objectives: Reactive oxygen species (ROS) play a role in neurodegenerative diseases, but ROS at moderate levels could stimulate biochemical processes through redox-sensitive transcription. Methods: Exercised or sedentary animals were injected subcutaneously with hydrogen peroxide (H 2 O 2 ), N-tert butyl-a-phenyl nitrone (PBN) or saline for the last 2 weeks of a 10-week experimental period to challenge redox balance. Free radical (FR) concentration was evaluated in the spinal cord by electron spin resonance, protein carbonyls, brain-derived neurotrophic factor (BDNF), glial cell linederived neurotrophic factor (GDNF) levels and the mRNA expression of BDNF receptor and tyrosine kinase receptor B (TrKB). Setting: Research Institute of Sport Science, Semmelweis University, Budapest, Hungary. Results: Exercise or PBN decreased the concentration of FR, whereas the carbonyl content did not change. BDNF was significantly decreased in exercised sham and sedentary PBN-treated groups, and its content correlated with the level of FR. GDNF was significantly increased in sedentary H 2 O 2 -treated groups. No differences were observed in TrkB mRNA expression among groups. Conclusions: Results suggest that regular exercise alone and PBN in sedentary animals can successfully decrease FR levels in the spinal cord. Redox alteration seems to affect the levels of GDNF and BDNF, which might have clinical consequences, as neurotrophins play an important role in cellular resistance and regeneration.

show abstract

The effect of exercise and nettle supplementation on oxidative stress markers in the rat brain

Cited by 91 publications

References 33 publications

The effect of nettle (<i>Urtica dioica</i>) extract on fattening performance and fatty acid profile in the meat and serum lipids of pigs

The effect of nettle (<i>Urtica dioica</i>) extract on fattening performance and fatty acid profile in the meat and serum lipids of pigs

Age-related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise

The effect of exercise and oxidant–antioxidant intervention on the levels of neurotrophins and free radicals in spinal cord of rats

Contact Info

Product

Resources

About