The Effect of Exercise Intensity on Anthropometric Parameters and Renal Damage in High Fructose- Induced Mice

Sari, Dewi Ratna; Ramadhan, Roy Novri; Agustin, Dini; Munir, Misbakhul; Izzatunnisa, Nabilah; Susanto, Joni; Halim, Shariff; Pranoto, Adi; Rejeki, Purwo Sri

doi:10.47197/retos.v51.101189

Cited by 3 publications

(2 citation statements)

References 84 publications

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“…Mice were used as an experimental unit because it is similar to human genetic, physiology, and biochemical characteristics (Herrmann et al, 2019). Mice were housed under standard conditions -ambient temperature 24 ± 2 °C, humidity 55 ± 10%, 12 h light/dark cycle (lights on from 7:00 to 19:00) (Ruanpang et al, 2018;Sari et al, 2024). Exclusion criteria were given to mice that were found deformed, injured, or inflamed on the limbs (front and back).…”

Section: Animalsmentioning

confidence: 99%

FNIP-1 Expression in Mice Muscle Negatively Correlated with Myoglobin Level and Endurance Performance on Treadmill Run Test

Yuliastrid,

Purwanto,

Kusnanik

et al. 2024

Retos

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Previously, FNIP-1 was found to play a critical role in the coupling of mitochondria function to restore ATP. Mitochondria was need to be supplied sufficient oxygen by myoglobin in the myocyte. We proposed that FNIP-1 also regulated myoglobin levels to support endurance performance. This study aimed to investigate whether FNIP-1 expression in muscle was correlated with myoglobin level and endurance performance on the treadmill run test. Male adult balb/c mice performed a run on the treadmill for as long as possible. The duration of running was measured as endurance performance. Its calf muscles were analyzed for myoglobin level and FNIP-1 expression. Lower FNIP-1 expression in calf muscle was found on higher levels of myoglobin and the longer duration of running on a treadmill. The Pearson test showed that the P value was <0.05, which indicated that there was a correlation between FNIP-1 and myoglobin with a score of -0.77, which indicated that there was a negative correlation. The Spearman test also showed that the P value was <0.05, which indicated that there was a correlation between FNIP-1 and endurance performance with a score of -0.70, which indicated that there was a negative correlation. So, FNIP-1 expression negatively correlated with myoglobin level and endurance performance of mice. Further study needs to investigate the FNIP-1 expression in human muscle to look at its correlation with the level of lactate, oxygen saturation (SaO2), oxygen fraction (FiO2), and maximum volume of oxygen uptake (VO2 max). Keywords: FNIP-1, muscle, endurance, myoglobin, healthy lifestyle.

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Section: Animalsmentioning

confidence: 99%

FNIP-1 Expression in Mice Muscle Negatively Correlated with Myoglobin Level and Endurance Performance on Treadmill Run Test

Yuliastrid,

Purwanto,

Kusnanik

et al. 2024

Retos

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“…Therefore, the aim of this study was to investigate the effects of one session of moderate-intensity continuous (MICT) training on the circulatory levels of FGF-21, resistin and adiponectin in physically inactive young adults. We selected MICT as exercise program given its previously described benefits in different contexts of health and disease (Collados-Gutiérrez & Gutiérrez Vilahú, 2023;Farhani et al, 2022;Sari et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Acute effects of moderate-intensity constant training on circulatory fibroblast growth factor 21, resis-tin, and adiponectin of physically inactive young adults

Carrasco-Molina,

Iuspa-Santelices,

Flores-Ojeda

et al. 2024

Retos

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Introduction: physical inactivity affects metabolic health, and it has been described that physical exercise is able to counter these disturbances. Fibroblast growth factor (FGF) 21, resistin, and adiponectin are known cytokines that are sensitive to physical inactivity and exercise, however, their acute behaviour after one session of exercise in physically inactive young adults is unclear. Therefore, this study aimed to investigate the effects of a session of moderate-intensity continuous training (MICT) on the circulatory levels of FGF21, resistin, and adiponectin of physically inactive young adults. Material and methods: quasi-experimental study, where 20 physically inactive young adults, with body mass indexes between 18 and 30 kg/m2 were included. All performed one MICT session, with an intensity of 60% of their heart rate reserve on a treadmill for 30 minutes. Anthropometric measurements were evaluated (weight, height, waist and hip circumferences, lean and fat mass) prior to exercise, and venous blood samples were taken before and after exercise, where glycemia, insulin, lipid profiles, transaminases, FGF21, resistin, and adiponectin were assessed. Results: one MICT session decreased the circulatory levels of insulin (median 23.5 vs 10.9 µUI/ml; p<0.05) and FGF21 (median 527 vs 409 pg/ml; p<0.05). On the other hand, resistin and adiponectin levels did not change after exercise (both p>0.05). Conclusion: one MICT session decreased FGF21 plasma levels, whereas it did not modify resistin and adiponectin circulatory levels. The specific mechanisms behind this different behavior are needed to be elucidated in future studies. Keywords: exercise, sedentary behavior, metabolic syndrome, endurance training, cytokines

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The Effect of Difference Training Intensity on Increased Adiponectin Levels in High-fructose-induced Mice (Mus musculus)

Puspita,

Rejeki,

Sari

et al. 2024

Rev. Investig. Innov. Cienc. Salud

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Introduction. The consumption of fructose in excessive quantities has been implicated in the onset of obesity and a spectrum of metabolic dysfunctions. Physical exercise is posited as a potent intervention to ameliorate obesity-induced metabolic anomalies, ostensibly through the elevation of adiponectin concentrations. However, the underlying molecular mechanisms of this effect remain inadequately understood. Objective. This study aims to demonstrate the impact of exercise intensity on increasing adiponectin levels in high-fructose-induced mice, highlighting the underlying molecular mechanisms. Methods. The experiment was carried out on 36 male mice (Mus musculus), aged ±8 weeks, with body weight ± 20 – 25 grams, in healthy condition and without defects. Mice were randomly divided into four groups. Control group without training (CN; n = 9); the low-intensity swimming training group with a 3% load of the mice's body weight (LI; n = 9); the moderate-intensity swimming training group with a 6% load of the mice's body weight (MI; n = 9); the heavy intensity swimming training group with a 9% load of the mice's body weight (HI; n = 9). The frequency of swimming training was carried out 3 times/week for 8 weeks, and the duration of swimming training was calculated as 80% of the maximum swimming time every session. All groups were orally (oral ad libitum) given 30% fructose solution for 8 weeks. Adiponectin levels were quantified via ELISA. Statistical interrogation employed one-way ANOVA and Tukey's HSD post hoc test, with a significance threshold set at 5%. Results. The results indicated a statistically significant divergence in adiponectin levels (p ≤ 0.001). Tukey's HSD post hoc test analysis revealed substantial disparities between CN and LI (p = 0.196), CN and MI (p = 0.0001), CN and HI (p = 0.001), LI and MI (p = 0.001), LI and HI (p = 0.001), and MI and HI (p = 0.001). Conclusion. This study found that moderate-intensity swimming training was more optimal in increasing adiponectin levels in fructose-induced mice compared to high-intensity, low-intensity, and control groups. Additionally, this research identified specific molecular pathways activated by moderate-intensity training, providing new insights for therapeutic interventions in tackling obesity-related metabolic dysfunctions.

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The Effect of Exercise Intensity on Anthropometric Parameters and Renal Damage in High Fructose- Induced Mice

Cited by 3 publications

References 84 publications

FNIP-1 Expression in Mice Muscle Negatively Correlated with Myoglobin Level and Endurance Performance on Treadmill Run Test

FNIP-1 Expression in Mice Muscle Negatively Correlated with Myoglobin Level and Endurance Performance on Treadmill Run Test

Acute effects of moderate-intensity constant training on circulatory fibroblast growth factor 21, resis-tin, and adiponectin of physically inactive young adults

The Effect of Difference Training Intensity on Increased Adiponectin Levels in High-fructose-induced Mice (Mus musculus)

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