The effect of exercise on depression and gut microbiota: Possible mechanisms

Yao, Mingchen; Qu, Yaqi; Zheng, Yalin; Guo, Hao

doi:10.1016/j.brainresbull.2024.111130

Brain Research Bulletin

2025

DOI: 10.1016/j.brainresbull.2024.111130

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The effect of exercise on depression and gut microbiota: Possible mechanisms

Mingchen Yao,

Yaqi Qu,

Yalin Zheng

et al.

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The Gut Microbiota’s Role in Neurological, Psychiatric, and Neurodevelopmental Disorders

Charitos,

Inchingolo,

Ferrante

et al. 2024

Nutrients

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Aim: This article aims to explore the role of the human gut microbiota (GM) in the pathogenesis of neurological, psychiatric, and neurodevelopmental disorders, highlighting its influence on health and disease, and investigating potential therapeutic strategies targeting GM modulation. Materials and Methods: A comprehensive analysis of the gut microbiota’s composition and its interaction with the human body, particularly, its role in neurological and psychiatric conditions, is provided. The review discusses factors influencing GM composition, including birth mode, breastfeeding, diet, medications, and geography. Additionally, it examines the GM’s functions, such as nutrient absorption, immune regulation, and pathogen defense, alongside its interactions with the nervous system through the gut–brain axis, neurotransmitters, and short-chain fatty acids (SCFAs). Results: Alterations in the GM are linked to various disorders, including Parkinson’s disease, multiple sclerosis, depression, schizophrenia, ADHD, and autism. The GM influences cognitive functions, stress responses, and mood regulation. Antibiotic use disrupts GM diversity, increasing the risk of metabolic disorders, obesity, and allergic diseases. Emerging therapies such as probiotics, prebiotics, and microbiota transplantation show promise in modulating the GM and alleviating symptoms of neurological and psychiatric conditions. Conclusions. The modulation of the GM represents a promising approach for personalized treatment strategies. Further research is needed to better understand the underlying mechanisms and to develop targeted therapies aimed at restoring GM balance for improved clinical outcomes.

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The Gut Microbiota’s Role in Neurological, Psychiatric, and Neurodevelopmental Disorders

Charitos,

Inchingolo,

Ferrante

et al. 2024

Nutrients

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show abstract

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The effect of exercise on depression and gut microbiota: Possible mechanisms

Cited by 1 publication

References 303 publications

The Gut Microbiota’s Role in Neurological, Psychiatric, and Neurodevelopmental Disorders

The Gut Microbiota’s Role in Neurological, Psychiatric, and Neurodevelopmental Disorders

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