The Effect of Exercise Training Intensity on Quality of Life in Heart Failure Patients: A Systematic Review and Meta-Analysis

Ostman, Cecilia; Jewiss, Daniel; Smart, Neil A.

doi:10.1159/000448088

Cited by 45 publications

(42 citation statements)

References 48 publications

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“…In fact, several studies, including systematic reviews and meta-analytic data, indicate that PE is capable of leading to changes in the pathophysiological course of different CVD, such as hypertension (HTN), coronary artery disease/myocardial infarction (MI) and heart failure (HF) 7,8,9,10 . Although the clinical effects of PE on the different CVD are already known, the mechanisms associated with such changes must still be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Exercise training on cardiovascular diseases: Role of animal models in the elucidation of the mechanisms

Rodrigues¹,

Feriani²,

Gambassi³

et al. 2017

Motriz: rev. educ. fis.

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Cardiovascular diseases, which include hypertension, coronary artery disease/myocardial infarction and heart failure, are one of the major causes of disability and death worldwide . On the other hand, physical exercise acts in the prevention and treatment of these conditions. In fact, several experiments performed in human beings have demonstrated the efficiency of physical exercise to alter clinical signals observed in these diseases, such as high blood pressure and exercise intolerance. However, even if human studies demonstrated the clinical efficiency of physical exercise, most extensive mechanisms responsible for this phenomenon still have to be elucidated. In this sense, studies using animal models seem to be a good option to demonstrate such mechanisms. Therefore, the aims of the present study are describing the main pathophysiological characteristics of the animal models used in the study of cardiovascular diseases, as well as the main mechanisms associated with the benefits of physical exercise.

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Section: Introductionmentioning

confidence: 99%

Exercise training on cardiovascular diseases: Role of animal models in the elucidation of the mechanisms

Rodrigues¹,

Feriani²,

Gambassi³

et al. 2017

Motriz: rev. educ. fis.

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“…A meta-analysis on 35 randomized controlled trials showed that isolated progressive resistance training exerted beneficial effects in lower (standardized MD, 0.57; 95% CI, -0.17 to -0.96) and upper [1.43 (0.73-2.13)] body strength. In addition, progressive resistance training plus aerobic training was more effective in both strength and fitness than aerobic training alone (Ostman et al, 2017). Twelve-month resistance in combination with aerobic exercise at a 2 days/week frequency may improve muscle strength and cardiorespiratory fitness in all age groups (Ciolac et al, 2014).…”

Section: Resistance and Aerobic Exercise And MImentioning

confidence: 93%

“…Exercise training concerns planned and organized body movement to improve physical capacities; examples include swimming, yoga, aerobic and resistance/strength exercise, and so on (Tulpule and Tulpule, 1980;Ferrera et al, 2014;Moraes-Silva et al, 2017;Ostman et al, 2017). After MI, Exercise training may induce positive effects; improve QoL, metabolic equivalents (METs), circulation function, and heart rate; and lower the risk of chronic disease and all-cause mortality (Greif et al, 1995;Adams et al, 2017;Elshazly et al, 2018;Mora and Valencia, 2018) (as shown in Figure 1).…”

Section: The Benefits Of Exercise For MImentioning

confidence: 99%

The Beneficial Role of Exercise Training for Myocardial Infarction Treatment in Elderly

et al. 2020

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Worldwide, elderly people have a higher prevalence of myocardial infarction (MI), which is associated with body function aging and a sedentary lifestyle. In addition to medication, exercise training is a well-established supplementary method to prevent and treat cardiovascular diseases (CVDs). Substantial evidence has shown the value of different intensity exercise programs in the prevention and treatment of MI, and exercise rehabilitation programs are also applicable to elderly patients with MI. Although exercise rehabilitation programs could significantly improve function, quality of life (QoL), and lower mortality and morbidity for people with MI, such programs are underused because their mechanisms are not accurately elucidated. To promote the application of exercise therapy for MI, this review summarizes the benefits and mechanisms of exercise rehabilitation for post-MI patients and provides rationalized proposals for outpatient cardiac rehabilitation.

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“…The physiological benefits of exercise training have long been appreciated. Research has demonstrated enormous cardiovascular benefits including decreased blood pressure in hypertensive individuals ( 1 ), improved glycemic control in diabetics ( 2 ), improved blood lipid profiles ( 3 ), and improved quality of life in heart failure patients ( 4 ). Exercise has also been shown to have beneficial effects on the vasculature including improvements in endothelial function ( 5 ) and atherosclerosis and plaque stability ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

An “Exercise” in Cardiac Metabolism

Kolwicz

2018

Front. Cardiovasc. Med.

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Research has demonstrated that the high capacity requirements of the heart are satisfied by a preference for oxidation of fatty acids. However, it is well known that a stressed heart, as in pathological hypertrophy, deviates from its inherent profile and relies heavily on glucose metabolism, primarily achieved by an acceleration in glycolysis. Moreover, it has been suggested that the chronically lipid overloaded heart augments fatty acid oxidation and triglyceride synthesis to an even greater degree and, thus, develops a lipotoxic phenotype. In comparison, classic studies in exercise physiology have provided a basis for the acute metabolic changes that occur during physical activity. During an acute bout of exercise, whole body glucose metabolism increases proportionately to intensity while fatty acid metabolism gradually increases throughout the duration of activity, particularly during moderate intensity. However, the studies in chronic exercise training are primarily limited to metabolic adaptations in skeletal muscle or to the mechanisms that govern physiological signaling pathways in the heart. Therefore, the purpose of this review is to discuss the precise changes that chronic exercise training elicits on cardiac metabolism, particularly on substrate utilization. Although conflicting data exists, a pattern of enhanced fatty oxidation and normalization of glycolysis emerges, which may be a therapeutic strategy to prevent or regress the metabolic phenotype of the hypertrophied heart. This review also expands on the metabolic adaptations that chronic exercise training elicits in amino acid and ketone body metabolism, which have become of increased interest recently. Lastly, challenges with exercise training studies, which could relate to several variables including model, training modality, and metabolic parameter assessed, are examined.

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The Effect of Exercise Training Intensity on Quality of Life in Heart Failure Patients: A Systematic Review and Meta-Analysis

Cited by 45 publications

References 48 publications

Exercise training on cardiovascular diseases: Role of animal models in the elucidation of the mechanisms

Exercise training on cardiovascular diseases: Role of animal models in the elucidation of the mechanisms

The Beneficial Role of Exercise Training for Myocardial Infarction Treatment in Elderly

An “Exercise” in Cardiac Metabolism

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