The effect of exercise training on clinical outcomes in patients with the metabolic syndrome: a systematic review and meta-analysis

Ostman, Cecilia; Smart, Neil A.; Morcos, D.; Duller, A.; Ridley, William E; Jewiss, Daniel

doi:10.1186/s12933-017-0590-y

Cited by 175 publications

(145 citation statements)

References 44 publications

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“…Increased physical activity (PA) reduces the cardiometabolic risk factors present in the MetS. 7,8 A recent systematic review showed a negative linear relationship between leisure-time PA and MetS incidence, concluding that any amount of leisure-time PA was more beneficial than none and that individuals exceeding current PA guidelines had substantially lower MetS incidence. 9 Moreover, data from a few large population-based samples indicate that active participants with clustered CVD risk factors have similar risks of CVD and all-cause mortality to active participants without risk factors.…”

Section: Introductionmentioning

confidence: 99%

Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome – a 20-year follow-up of a population-based cohort of 60-year-olds

Ekblom-Bak

Halldin

Vikström

et al. 2020

European Journal of Preventive Cardiology

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Aims The purpose of this study was to analyse the association of leisure-time physical activity of different intensities at baseline, and cardiovascular disease incidence, cardiovascular disease mortality and all-cause mortality in a population-based sample of 60-year-old men and women with and without established metabolic syndrome, for more than 20 years of follow-up. A secondary aim was to study which cardiometabolic factors may mediate the association between physical activity and long-term outcomes. Methods A total of 3693 participants (53% women) underwent physical examination and laboratory tests, completed an extensive questionnaire at baseline 1997–1999 and were followed until their death or until 31 December 2017. First-time cardiovascular disease events and death from any cause were ascertained through regular examinations of national registers. Results Metabolic syndrome prevalence was 23.0%. In metabolic syndrome participants, light physical activity attenuated cardiovascular disease incidence (hazard ratio = 0.71; 95% confidence interval 0.50–1.00) compared to sedentary (reference) after multi-adjustment. Moderate/high physical activity was inversely associated with both cardiovascular disease and all-cause mortality, but became non-significant after multi-adjustment. Sedentary non-metabolic syndrome participants had lower cardiovascular disease incidence (0.47; 0.31–0.72) but not significantly different cardiovascular disease (0.61; 0.31–1.19) and all-cause mortality (0.92; 0.64–1.34) compared to sedentary metabolic syndrome participants. Both light and moderate/high physical activity were inversely associated with cardiovascular disease and all-cause mortality in non-metabolic syndrome participants ( p<0.05). There were significant variations in several central cardiometabolic risk factors with physical activity level in non-metabolic syndrome participants. Fibrinogen mediated the protective effects of physical activity in non-metabolic syndrome participants. Conclusion Physical activity of different intensities attenuated cardiovascular risk and mortality in 60-year old men and women with metabolic syndrome during a 20-year follow-up.

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Section: Introductionmentioning

confidence: 99%

Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome – a 20-year follow-up of a population-based cohort of 60-year-olds

Ekblom-Bak

Halldin

Vikström

et al. 2020

European Journal of Preventive Cardiology

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“…It was suggested that multidisciplinary group approach is an effective and economically feasible strategy in the control of metabolic parameters (26). It was also reported that modifying diet together with frequent physical exercise can reduce the triglycerides concentration as well as SBD and DBP (24,27,28). The need for implementing effective lifestyle modifications to prevent MetS and its health consequences has been indicated (24,29).…”

Section: Resultsmentioning

confidence: 99%

Effect of Behaviour Change Communication on Metabolic Syndrome and Its Markers among Ethiopian Adults: Randomized Controlled Trial

Sinaga

Lindstrom

Teshome

et al. 2020

Preprint

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Background: Metabolic syndrome is a global public health problem affecting both developing and developed countries with major consequences on human health, social and economic development. In Ethiopia although there is an increase in the prevalence of metabolic Syndrome due to epidemiologic transition, there is no study that evaluated the effect of interventions. This study aimed to assess the effect of nutrition behaviour change communication on metabolic syndrome and its markers. Method: A individually randomized controlled trial was conducted among Ethiopian adults working in Jimma University from mid of September 2015 to December 30, 2015. A total of 224 participants were randomly allocated into intervention (n=112) and controls (n=112) groups. The list of administrative and academic staff involved in the baseline survey was used as a sampling frame. Data on socio-demographic, anthropometric, biochemical and clinical parameters were collected using trained data collectors. Difference in the differences in metabolic syndrome and its components between baseline and end line were compared by the intervention status. Multivariable logistic and linear regression models were used to isolate independent predictors of metabolic syndrome and its components, respectively. Results: Overall, there was significant difference (P<0.001) in the prevalence of metabolic syndrome between intervention (11.6%) and control groups (37.5%) on the end line survey. On multivariable logistic regression analyses, control groups were 8.5 times more likely to have metabolic syndrome compared to intervention groups (AOR=8.53, 95%CI: 3.60, 20.21, P <0.001). There was a significant mean difference in differences in most components of metabolic syndrome and other lipid profiles except HDL (P=0.717) in the intervention group. The mean difference in differences in waist circumference was 6.3 cm (P<0.001), while that of systolic blood pressure (BP) and diastolic BP were 6.1 mmHg (P< 0.001) and 3.6 mmHg (P=0.001), respectively. Likewise the difference of differences between intervention and control groups was 30.7 mg/dl (P<0.001) for T.Cholesterol, 55.5 mg/dl (P<0.001) for triglycerides, 21.9 mg/dl (P=0.015) for LDL and 22.2 mg/dl (P<0.001) for fasting blood sugar. Further multivariable linear regression analyses showed that after adjusting for many variables, there was a significant difference in difference between intervention groups in components of metabolic syndrome. For the intervention group the mean difference in differences was 6.1cm (β=6.1, P<0.001) for waist circumference and 4.2 mm Hg (β=4.2, P<0.05) for diastolic blood pressure and 6.5 mmHg (β=6.5, P<0.001) for systolic blood pressure compared with controls. Similarly, the mean difference in differences was higher in the intervention group by 19.9 mg/dl (β=19.9, P<0.05) for FBS, 57.5 mg/dl for TG (β=57.5, P<0.05), 24.40 mg/dl for LDL (β=24.4, P<0.05) and 30.9mg/dl for T.Cholestrol (β=30.9, P<0.001). This trial is retrospectively registered on Pan African Clinical Trial Registration with unique identification number of PACTR202003465339638. Conclusion: There was strong positive effect of behaviour change communication on metabolic syndrome and its components. The results imply the need for enhancing behaviour change interventions using various strategies at the community and health facility levels to curb the emerging burden of chronic non-communicable diseases in Ethiopia. Future research should examine the sustainability of such behaviour changes using a community based study.

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“…Exercise is widely accepted as a useful means for both the prevention and treatment of metabolic diseases (Ostman et al 2017). The underlying mechanisms of the beneficial impact of exercise on metabolic health are not yet fully understood.…”

Section: Skeletal Muscle Metabolism Is Crucial In Controlling Systemimentioning

confidence: 99%

RabGAPs in skeletal muscle function and exercise

Espelage

Al-Hasani

Chadt

2020

Journal of Molecular Endocrinology

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The two closely related RabGAPs TBC1D1 and TBC1D4 are key signaling factors of skeletal muscle substrate utilization. In mice, deficiency in both RabGAPs leads to reduced skeletal muscle glucose transport in response to insulin and lower GLUT4 abundance. Conversely, Tbc1d1 and Tbc1d4 deficiency results in enhanced lipid use as fuel in skeletal muscle, through yet unknown mechanisms. In humans, variants in TBC1D1 and TBC1D4 are linked to obesity, insulin resistance and type 2 diabetes. While the specific function in metabolism of each of the two RabGAPs remains to be determined, TBC1D1 emerges to be controlling exercise endurance and physical capacity, whereas TBC1D4 may rather be responsible for maintaining muscle insulin sensitivity, muscle contraction, and exercise. There is growing evidence that TBC1D1 also plays an important role in skeletal muscle development, since it has been found to be associated to meat production traits in several livestock species. In addition, TBC1D1 protein abundance in skeletal muscle is regulated by both, insulin receptor and insulin-like growth factor-1 (IGF-1) receptor signaling. This review focuses on the specific roles of the two key signaling factors TBC1D1 and TBC1D4 in skeletal muscle metabolism, development and exercise physiology.

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The effect of exercise training on clinical outcomes in patients with the metabolic syndrome: a systematic review and meta-analysis

Cited by 175 publications

References 44 publications

Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome – a 20-year follow-up of a population-based cohort of 60-year-olds

Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome – a 20-year follow-up of a population-based cohort of 60-year-olds

Effect of Behaviour Change Communication on Metabolic Syndrome and Its Markers among Ethiopian Adults: Randomized Controlled Trial

RabGAPs in skeletal muscle function and exercise

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