The effect of experimental pain on motor training performance and sensorimotor integration

Dancey, Erin; Murphy, Bernadette; Srbely, John; Yielder, Paul

doi:10.1007/s00221-014-3966-1

Cited by 36 publications

(93 citation statements)

References 171 publications

(391 reference statements)

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“…25,75 However, associative motor learning in the context of pain-eliciting voluntary movements is not well understood. Animal models show pain-related deficits in motor learning, 23,29 and human studies show that pain can inhibit, 10,37 or facilitate, 16 or not affect motor learning, 31 but these studies do not provide insights into the role that cerebellar circuits play in pain-related adaptive or maladaptive changes in motor learning. The current findings may benefit patients in the future by identifying specific cerebellar targets for interventions such as noninvasive brain stimulation to modulate pain-eliciting movements during rehabilitation.…”

Section: Discussionmentioning

confidence: 94%

“…This is the first study to use the spatially unbiased infratentorial template (SUIT) of the cerebellum 16,17 to examine brain activity during pain and motor processing. We tested the hypothesis that common activation during pain and motor processing will be limited to the well-known superior and inferior cerebellar hand regions (lobules V-VI and VIII).…”

Section: Introductionmentioning

confidence: 99%

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Pain and motor processing in the human cerebellum

Coombes

Misra²

2016

Pain

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Pain-related adaptations in movement require a network architecture that allows for integration across pain and motor circuits. Previous studies addressing this issue have focused on cortical areas such as the midcingulate cortex. Here, we focus on pain and motor processing in the human cerebellum. The goal of this study was to identify areas of activation in the cerebellum, which are common to pain and motor processing, and to determine whether the activation is limited to the superior and inferior cerebellar motor maps or extends into multimodal areas of the posterior cerebellum. Our observations identified overlapping activity in left and right lobules VI and VIIb during pain and motor processing. Activation in these multimodal regions persisted when pain and motor processes were combined within the same trial, and activation in contralateral left lobule VIIb persisted when stimulation was controlled for. Functional connectivity analyses revealed significant correlations in the BOLD time series between multimodal cerebellar regions and sensorimotor regions in the cerebrum including anterior midcingulate cortex, supplementary motor area, and thalamus. The current findings are the first to show multimodal processing in lobules VI and VIIb for motor control and pain processing and suggest that the posterior cerebellum may be important in understanding pain-related adaptations in motor control.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Pain and motor processing in the human cerebellum

Coombes

Misra²

2016

Pain

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“…It would be of interest in further studies to assess both pain-induced modulation in S1 excitability and SAI given the results of recent studies showing that a decrease in S1 excitability induced by non-invasive stimulation results in a reduction of the amount of SAI. At this stage, the impact of nociceptive stimuli on S1 excitability (as measured by the short latency components of somatosensory evoked potentials) remains unclear, especially for cutaneous nociceptive modalities [30,31,40,41,42,43,44,45]. One also needs to consider that the nociceptive modality and the location of the nociceptive stimuli with respect to the tested muscle might influence the results.…”

Section: Discussionmentioning

confidence: 99%

Effect of Experimental Cutaneous Hand Pain on Corticospinal Excitability and Short Afferent Inhibition

et al. 2016

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Sensorimotor integration is altered in people with chronic pain. While there is substantial evidence that pain interferes with neural activity in primary sensory and motor cortices, much less is known about its impact on integrative sensorimotor processes. Here, the short latency afferent inhibition (SAI) paradigm was used to assess sensorimotor integration in the presence and absence of experimental cutaneous heat pain applied to the hand. Ulnar nerve stimulation was combined with transcranial magnetic stimulation to condition motor evoked potentials (MEPs) in the first dorsal interosseous muscle. Four interstimulus intervals (ISI) were tested, based on the latency of the N20 component of the afferent sensory volley (N20−5 ms, N20+2 ms, N20+4 ms, N20+10 ms). In the PAIN condition, MEPs were smaller compared to the NEUTRAL condition (p = 0.005), and were modulated as a function of the ISI (p = 0.012). Post-hoc planned comparisons revealed that MEPs at N20+2 and N20+4 were inhibited compared to unconditioned MEPs. However, the level of inhibition (SAI) was similar in the PAIN and NEUTRAL conditions. This suggests that the interplay between pain and sensorimotor integration is not mediated through direct and rapid pathways as assessed by SAI, but rather might involve higher-order integrative areas.

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“…While several studies have described the immediate effect of pain on motor performance [2], its effect on motor learning has been less investigated [3–10]. Among the studies who did look at the effect of pain on motor learning, only a few have considered its impact on the retention of new motor skills [8–10], rather than simply looking at improvement during practice (i.e., skill acquisition).…”

Section: Introductionmentioning

confidence: 99%

Pain Induced during Both the Acquisition and Retention Phases of Locomotor Adaptation Does Not Interfere with Improvements in Motor Performance

et al. 2016

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Cutaneous pain experienced during locomotor training was previously reported to interfere with retention assessed in pain-free conditions. To determine whether this interference reflects consolidation deficits or a difficulty to transfer motor skills acquired in the presence of pain to a pain-free context, this study evaluated the effect of pain induced during both the acquisition and retention phases of locomotor learning. Healthy participants performed a locomotor adaptation task (robotized orthosis perturbing ankle movements during swing) on two consecutive days. Capsaicin cream was applied around participants' ankle on both days for the Pain group, while the Control group was always pain-free. Changes in movement errors caused by the perturbation were measured to assess global motor performance; temporal distribution of errors and electromyographic activity were used to characterize motor strategies. Pain did not interfere with global performance during the acquisition or the retention phases but was associated with a shift in movement error center of gravity to later in the swing phase, suggesting a reduction in anticipatory strategy. Therefore, previously reported retention deficits could be explained by contextual changes between acquisition and retention tests. This difficulty in transferring skills from one context to another could be due to pain-related changes in motor strategy.

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The effect of experimental pain on motor training performance and sensorimotor integration

Cited by 36 publications

References 171 publications

Pain and motor processing in the human cerebellum

Pain and motor processing in the human cerebellum

Effect of Experimental Cutaneous Hand Pain on Corticospinal Excitability and Short Afferent Inhibition

Pain Induced during Both the Acquisition and Retention Phases of Locomotor Adaptation Does Not Interfere with Improvements in Motor Performance

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