The Effect of Extraction Condition on The Polyphenol Content and Antioxidant Activity of Curcuma zedoaria (Christm.) Roscoe Rhizome

Marliani, Lia; Budiana, Wempi; Anandari, Yonara

doi:10.15416/ijpst.v4i2.12770

Cited by 9 publications

(15 citation statements)

References 3 publications

(5 reference statements)

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“…), masingmasing 800 g simplisia di ekstraksi menggunakan metode maserasi dengan pelarut etanol 96% sebanyak 4000 ml, dilakukan dengan penggantian pelarut sebanyak 3x24 jam. Setelah selesai kemudian ekstrak yang didapat dipekatkan menggunakan rotary evaporator untuk memperoleh ekstrak pekat [8] . [19] .…”

Section: Karakterisasi Simplisiaunclassified

“…Pemastian mutu simplisia yang digunakan dalam pengujian dengan parameter uji kadar abu total, kadar sari larut air, kadar sari larut etanol dan susut pengeringan menunjukkan simplisia memenuhi standar mutu [18] sebagaimana yang ditampilkan dalam Tabel I. Proses ekstraksi dilakukan menggunakan metode maserasi karena senyawa yang terkandung dalam ekstrak uji yaitu senyawa golongan kurkuminoid mempunyai sifat tidak stabil dalam pemanasan. Waktu kontak yang lebih lama antara pelarut dan simplisia memungkinkan proses penarikan senyawa aktif lebih optimal [8,21] . mengakibatkan terhambatnya pertumbuhan mikroba [23] .…”

Section: Hasil Dan Pembahasanunclassified

“…[2,4] . Selain memiliki aktivitas antioksidan [8] , rimpang temu putih juga dapat menghambat pertumbuhan bakteri maupun jamur [9][10][11] . [12] .…”

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Penapisan Fitokimia, Kadar Kurkuminoid dan Aktivitas Antibakteri Temu Hitam (Curcuma aeruginosa (Christm) Roscoe.), Temu Putih (Curcuma zedoaria Roxb.) dan Temulawak (Curcuma xanthorrhiza Roxb.)

Marliani

Sukmawati

Juanda

et al. 2021

HMJ

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The content of secondary metabolites in the rhizome of the Curcuma genus such as Black turmeric (Curcuma aeruginosa Roxb.), White turmeric (Curcuma zedoaria (Christm.) Roscoe) and Java turmeric (Curcuma xanthorrhiza Roxb.) play a role in various pharmacological activities. One of them is the content of the curcuminoid compounds which have been proved to have antibacterial activity. This study aims to screen the content of secondary metabolite compounds, determine curcuminoid content and verify the antibacterial activity of the extracts of Black turmeric (Curcuma aeruginosa Roxb.), White turmeric (Curcuma zedoaria (Christm.) Roscoe) and Java turmeric (Curcuma xanthorrhiza Roxb.). Extraction was carried out by the maceration method using 95% ethanol as solvent. Phytochemical screening was tested for the content of alkaloid, polyphenols, flavonoids, quinones, tannins, saponins, and steroids/ triterpenoids compounds. Determination of curcuminoid content by UV-Vis Spectrophotometry method. The antibacterial activity test was carried out by the microdilution method against Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acne bacteria. The results of phytochemical screening showed that the three extracts contained polyphenols and flavonoids. Quinone compounds are only contained in the extract of Black turmeric and Java turmeric. Saponin compounds were only detected in Black turmeric and White turmeric extracts. Meanwhile, steroid/ triterpenoid compounds were detected in the extract of White turmeric and Java turmeric. The results of curcuminoid content determination on the three extracts showed that the Java turmeric extract had the highest content of curcuminoids (16.07 ± 0.023 mg CE/g extract). The results of the antibacterial test showed the strongest activity of the three test samples shown by Java turmeric extract with a minimum inhibitory concentration (MIC) value of 64 mg/mL against Staphylococcus aureus bacteria; 256 mg/mL against Staphylococcus epidermidis bacteria; and 32 mg/mL against the Propionibacterium acne bacteria. These results indicate that Java turmeric extract is more active against Propionibacterium acne bacteria.

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Section: Karakterisasi Simplisiaunclassified

Section: Hasil Dan Pembahasanunclassified

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Penapisan Fitokimia, Kadar Kurkuminoid dan Aktivitas Antibakteri Temu Hitam (Curcuma aeruginosa (Christm) Roscoe.), Temu Putih (Curcuma zedoaria Roxb.) dan Temulawak (Curcuma xanthorrhiza Roxb.)

Marliani

Sukmawati

Juanda

et al. 2021

HMJ

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“…Polifenol dikenal dengan antioksidan yang kuat dapat mencegah pembentukan radikal bebas. Selain sebagai antioksidan, rimpang C. zedoaria memiliki manfaat sebagai obat, diantaranya antiinflamasi, anti kanker dan anti mikroba [3].…”

Section: Pendahuluanunclassified

PEMBUATAN SERBUK INSTAN KUNYIT PUTIH (Curcuma zedoaria (Bergius) Roscoe.) DAN KACANG MERAH (Phaseolus vulgaris L.) SEBAGAI ANTIOKSIDAN

Sabilah¹,

Andriani²,

Suharti³

2020

J. Holist. Heal. Sci.

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Latar Belakang: Radikal bebas dapat memicu penyebab beberapa penyakit seperti kanker, gangguan fungsi ginjal, serangan jantung dan katarak. Antioksidan alami dapat membantu menetralisir radikal bebas dalam tubuh manusia. Serbuk instan kunyit putih dan kacang merah ini memiliki kandungan kaya akan antioksidan karena kunyit putih dan kacang merah mengandung polifenol yang dikenal sebagai antioksidan. Tujuan Penelitian: Penelitian ini bertujuan untuk membuat sediaan serbuk instan kunyit putih (Curcuma zedoaria) dan kacang merah (Phaseolus vulgaris L.) sebagai antioksidan serta mencari formulasi terbaik berdasarkar uji organoleptik selama 3 minggu. Metode: Disain penelitian ini adalah penelitian tindakan, yang terdiri dari tahap perencanan, pelaksanaan, pengamatan dan refleksi atau evaluasi. Penelitian ini dibagi menjadi dua tahap yaitu tahap pertama, proses pembuatan sedian serbuk instan dengan metode kristalisasi dan tahap kedua, uji organoleptik sediaan serbuk instan. Hasil: Hasil penelitian dari pembuatan serbuk instan kunyit putih dan kacang merah menghasilkan jumlah yang berbeda-beda yaitu FI 164 gram, FII 361 gram dan FIII 541 gram. Hasil uji organoleptik dari ketiga sampel menunjukan tidak adanya perubahan yang signifikan dalam hal bau, bentuk, rasa dan warna. Formula terbaik setelah uji organoleptik selama 3 minggu yaitu FII 1:1 (sari 400 ml : gula 400 g). Simpulan: Penelitian ini menunjukan bahwa serbuk instan kunyit putih dan kacang merah yang memiliki formulasi terbaik berdasarkan uji organoleptik selama 3 minggu yaitu pada FII 1:1 (sari 400 ml : gula 400 g).

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“…Polyphenols are thought to be a potential antioxidants of this plant (3). The Phenolic or polyphenols were include to flavonoids, which are known to be modifiers biological response, functions as metal chelators and eradicating free radicals (4).…”

Section: Introductionmentioning

confidence: 99%

Liver Histopathological Change and Malondialdehyde Level of Rattus Norvegicus on Administration of Curcuma Zedoaria and Paracetamol Toxic Dose

Tania

Misuari

Yudhayana

et al. 2021

IJMLST

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High doses of paracetamol create necrosis in the liver and produce free radicals. When liver function decreased in a long time, it will lead to severe liver damage and it will be irreversible. Rhizome of Curcuma zedoaria has the potential effect as an antioxidant, it is assumed that its properties inhibit the formation of free radicals which formed from toxic doses of paracetamol. The aim of this study was to examine the histological structure of the liver and to determine MDA levels in the administration of C. zedoaria toxic dose and paracetamol on the Rattus norvegicus. The study was used twenty-four rats divided into four groups (positive control: CMC 0.5%; negative control: paracetamol 1.35g/kg body weight; treatment group 1 (T1): C. zedoaria 105 mg/200g and paracetamol 1.35g/kg Body weight 2 hours later, and treatment group 2 (T2): paracetamol 1.35g/ kg Body weight and C. zedoaria 105 mg/200g 2 hours later). The Kruskall-Wallis test results showed MDA level did not significantly different between groups (p = 0.087). Hepatocellular changes were observed descriptively with Hematoxylin-eosin staining. Positive control showed greater hepatocellular changes rather than other groups, hepatocyte cells were enlarged with cytoplasm showing eosinophilic granules infiltrates, enlarged irregular nuclei, nucleolus prominent, there are many necrosis cells.

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The Effect of Extraction Condition on The Polyphenol Content and Antioxidant Activity of Curcuma zedoaria (Christm.) Roscoe Rhizome

Cited by 9 publications

References 3 publications

Penapisan Fitokimia, Kadar Kurkuminoid dan Aktivitas Antibakteri Temu Hitam (Curcuma aeruginosa (Christm) Roscoe.), Temu Putih (Curcuma zedoaria Roxb.) dan Temulawak (Curcuma xanthorrhiza Roxb.)

Penapisan Fitokimia, Kadar Kurkuminoid dan Aktivitas Antibakteri Temu Hitam (Curcuma aeruginosa (Christm) Roscoe.), Temu Putih (Curcuma zedoaria Roxb.) dan Temulawak (Curcuma xanthorrhiza Roxb.)

PEMBUATAN SERBUK INSTAN KUNYIT PUTIH (Curcuma zedoaria (Bergius) Roscoe.) DAN KACANG MERAH (Phaseolus vulgaris L.) SEBAGAI ANTIOKSIDAN

Liver Histopathological Change and Malondialdehyde Level of Rattus Norvegicus on Administration of Curcuma Zedoaria and Paracetamol Toxic Dose

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