The effect of extracts from ginger rhizome on inflammatory mediator production

Lantz, R. Clark; Chen, G.J.; Sarihan, M.; Solyom, Aniko M; Jolad, Shivanand D.; Timmermann, Barbara N.

doi:10.1016/j.phymed.2006.03.003

Cited by 257 publications

(186 citation statements)

References 14 publications

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“…Apesar de ser uma excelente ferramenta para determinar a atividade antioxidante de compostos redutores e de ser aplicável a sistemas hidrofílicos e lipofílicos, 69 este método mostra uma baixa seletividade do radical na reação com compostos doadores de hidrogênio. 50 . Resultados: Média ± DP de reduzir radicais livres.…”

Section: Resultsunclassified

“…[28][29][30] Seus extratos e seus principais compostos pungentes, os gingeróis, têm mostrado recentemente variada atividade biológica, incluindo efeito como agentes antineoplásicos, 26,[31][32][33][34][35][36][37][38][39][40] antiespasmódicos e antieméticos, 41 inibidores de enzimas, 42 anti-hemorrágicos, 43 antifúngicos, 44 inibitórios da sínte-se de oxido nítrico, 45 protetores de células neurais, 46 anti-reumáticos, 47 microbicidas, 10 antiinflamatórios e antioxidantes. 36,40,[48][49][50] De modo geral, os trabalhos presentes na literatura descrevem vários estudos relacionados com as principais atividades apresentadas pelos extratos ativos de alecrim e gengibre e seus principais compostos, mostrando que apesar dos mecanismos biológicos pelos quais os principais componentes dos extratos ativos destas plantas manifestam seus efeitos nos sistemas celulares não terem sido ainda completamente elucidados, 28,30 existe um grande interesse na utilização deste tipo de compostos, principalmente do ponto de vista terapêutico.…”

Section: Introductionunclassified

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Avaliação do potencial antioxidante de extratos ativos de plantas obtidos por extração com fluido supercrítico

Justo¹,

Moraes²,

Barreto³

et al. 2008

Quím. Nova

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Recebido em 23/10/07; aceito em 30/4/08; publicado na web em 19/9/08 EVALUATION OF THE ANTIOXIDANT POTENTIAL OF PLANT EXTRACTS OBTAINED BY SUPERCRITICAL FLUID EXTRACTION. The aim of this work was to evaluate the antioxidant properties of ginger and rosemary extracts, obtained by supercritical extraction. The extracts were characterized by HPLC, GC-MS, phenolic compounds content and antioxidant activity. The main active compounds were identified and high content of phenolic compounds was observed. The extracts presented high antioxidant activity against the free radicals ABTS•+ (350 and 200 mM Trolox/g, for ginger and rosemary, respectively) and DPPH• (145 and 80 mM Trolox/g, for ginger and rosemary, respectively). These results suggested that the attained extracts are potential substitutes of synthetic antioxidants used in chemical, food and pharmaceutical industries.Keywords: active plant extracts; supercritical fluid extraction; antioxidant activity. introduçãoOs recursos naturais continuam sendo importantes fontes de substâncias e precursores com grande potencial terapêutico, não apenas pelo grande número de espécies vegetais com propriedades medicinais inexploradas, mas principalmente pela variedade de metabólitos primários e secundários por elas sintetizados. Uma porcentagem considerável da população que vive em países em desenvolvimento faz uso da medicina tradicional, incluindo as plantas medicinais nos cuidados primários da saúde. 1 A busca de novos agentes farmacologicamente ativos, através da triagem de fontes naturais, tem levado à descoberta de muitos fármacos úteis clinicamente e que desempenham um importante papel no tratamento de várias doenças. Especificamente na terapia de enfermidades infecciosas e do câncer, estima-se que mais de 75 e 60%, respectivamente, dos fármacos atualmente empregados são derivados de fontes naturais, 2,3 sendo muito deles compostos com atividade antioxidante que podem agir em diversos níveis da seqüência oxidativa nos sistemas biológicos. 4,5 A família Labiatae compreende 150 gêneros com aproximadamente 3500 espécies, nativas principalmente do Mediterrâneo, embora algumas tenham origem na Austrália, Sudoeste da Ásia e América do Sul. As principais espécies desta família são o alecrim, a sálvia, o orégano, o tomilho, o manjericão, a manjerona e a menta. Dentre estas espécies, os extratos ativos de alecrim e sálvia têm sido os mais estudados nos últimos anos. Antropologistas e arqueologistas têm encontrado evidências do uso do alecrim como planta medicinal desde a época do Egito antigo. 6 As propriedades antioxidantes dos extratos de alecrim (Rosmarinus officinalis Labiatae) têm recebido considerável atenção nos últimos anos. Na indústria de alimentos, seus efeitos antioxidativos têm se mostrado superiores aos do antioxidante sintético BHA e semelhantes aos do BHT. Comercialmente, tem sido usado em combinação com tocoferóis, observando-se sinergismo entre o alecrim e o α-tocoferol (o extrato de alecrim regenera o tocoferol). O alecrim também tem demonstrado efeito sinérgi...

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Section: Resultsunclassified

Section: Introductionunclassified

Avaliação do potencial antioxidante de extratos ativos de plantas obtidos por extração com fluido supercrítico

Justo¹,

Moraes²,

Barreto³

et al. 2008

Quím. Nova

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“…Several lines of evidence have been provided, mostly in different animal models of inflammation, and to a much lesser extent in humans or human cells, of the effectiveness of either ginger or of compounds isolated there from against inflammation and its mediators. [26,30] Here, in this study, we studied the anti-inflammatory properties of synthesized flavonoids from naturally occurring phenolic compounds by using different in vitro assays viz. ;…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Antioxidant, anti‐inflammatory, and enzyme inhibitory activity of natural plant flavonoids and their synthesized derivatives

Nile

Keum

Nile

et al. 2017

J Biochem & Molecular Tox

111

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The synthesized flavonoid derivatives were examined for their antioxidant, anti-inflammatory, xanthine oxidase (XO), urease inhibitory activity, and cytotoxicity. Except few, all the flavonoids under this study showed significant antioxidant activity (45.6%-85.5%, 32.6%-70.6%, and 24.9%-65.5% inhibition by DPPH, ferric reducing/antioxidant power, and oxygen radical absorption capacity assays) with promising TNF-inhibitory activity (42%-73% at 10 M) and IL-6 inhibitory activity (54%-81% at 10 M) compared with that of control dexamethasone. The flavonoidsO 7 -hexyl chrysin, showed an inhibition with IC 50 values (4.5-8.1 g/mL), more than allopurinol (8.5 g/mL) at 5 M against XO and showing more than 50% inhibition at a final concentration (5 mM) with an IC 50 value of ranging from 4.8 to 7.2 ( g/mL) in comparison with the positive control thiourea (5.8 g/mL) for urease inhibition. Thus, the flavonoid derivatives may be considered as potential antioxidant and antigout agents.

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“…Many studies were carried out on the pungent constituents of fresh and dried ginger rhizomes. Among the pharmacological effects demonstrated are antiplatelets, antioxidant, anti-tumor, anti-rhino viral, anti-hepatotoxicity, anti-arthritic effect and anti-inflammatory [3][4][5]. The 6-Gingerol is an important active principle of plant which has been used as a marker compound for quality control and standardization of the plant and its formulations.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Method for Densitometric Analysis of 6-Gingerol in Herbal extracts and Polyherbal Formulation

Jain¹,

Tatiya²,

Bagul³

2011

J Anal Bioanal Techniques

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ValidationLinearity: The linear regression data for the calibration curves showed good linear relationship over the concentration range 150-900ng/spot. Linear regression equation was found to be Y = 4.103x+398.6 (r 2 = 0.9981). The result is expressed in Table 1. Precision:The precision of the developed HPTLC method was expressed in terms of % relative standard deviation (% R.S.D.). The results depicted revealed high precision of the method is presented in Table 2.Repeatability: Ruggedness of the method was per-formed by applying 400ng by two different analyst keeping same experimental and environmental conditions. The % R.S.D was found to be 0.45. LOD and LOQ: Detection limit and quantification limit was calculated by the method as described in Specificity. The LOQ and LOD were 24.13ng and 63.83ng. This indicates that adequate sensitivity of the method. Robustness:The standard deviation of peak areas was calculated for each parameter and % R.S.D. was found to be less than 2 %. Accuracy:The proposed method when used for extraction and subsequent estimation of both the drug from pharmaceutical dosage forms after over spotting with 80, 100 and 120 % of additional drug; afforded recovery of 98.2 -99.63 % as listed in Table 3. Paramaters 6-GingerolLinearity range (ng/spot) 150-900Calibration curve equation y = 4.103x + 398.6Correlation coefficient 0.9981

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The effect of extracts from ginger rhizome on inflammatory mediator production

Cited by 257 publications

References 14 publications

Avaliação do potencial antioxidante de extratos ativos de plantas obtidos por extração com fluido supercrítico

Avaliação do potencial antioxidante de extratos ativos de plantas obtidos por extração com fluido supercrítico

Antioxidant, anti‐inflammatory, and enzyme inhibitory activity of natural plant flavonoids and their synthesized derivatives

Development and Validation of a Method for Densitometric Analysis of 6-Gingerol in Herbal extracts and Polyherbal Formulation

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