The effect of fecal microbiota transplantation on autistic-like behaviors in Fmr1 KO mice

Goo, Nayeon; Bae, Ho Jung; Park, Keontae; Kim, Jae-Hoon; Jeong, Yongwoo; Cai, Mudan; Cho, Kyungnam; Kim, Dong-Hyun; Ryu, Jong Hoon

doi:10.1016/j.lfs.2020.118497

Cited by 34 publications

(26 citation statements)

References 52 publications

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“…Deficits in the gut microbial composition and their metabolic contents such as vitamin and neurotransmitters may be involved in the development of autistic-like social behaviors in these autism mice [ 107 ]. Importantly, children with autism showed a significant improvement in autistic and gastrointestinal symptoms after treatment with fecal microbiota transplantation [ 108 ], and these benefits prolong for years as reported in a follow-up study with the same participants [ 109 ].…”

Section: Influence Of Gut Microbe-regulated Neurotransmitter Synthesis On Cognitionmentioning

confidence: 99%

Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

2021

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Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among the metabolic, peripheral immune, and central nervous systems via the microbiota–gut–brain axis. However, it is not well understood how the gut microbiome and neurons in the brain mutually interact or how these interactions affect normal brain functioning and cognition. We summarize the mechanisms whereby the gut microbiota regulate the production, transportation, and functioning of neurotransmitters. We also discuss how microbiome dysbiosis affects cognitive function, especially in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.

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Section: Influence Of Gut Microbe-regulated Neurotransmitter Synthesis On Cognitionmentioning

confidence: 99%

Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

2021

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“…Studies performed in animal models showed that FMT is effective is transferring/restoring disease-associated features: (i) FMT using fecal transplants derived from normal mice into a mouse model of Parkinson’s disease reduced Parkinson-related signatures, namely, microglia and astrocyte activation in the substantia nigra, gut microbial dysbiosis, and decreased fecal SCFAs, and it alleviated physical impairment and increased striatal dopamine and serotonin content ( Sun et al, 2018 ); (ii) FMT using fecal transplants obtained from people with major depression into normal mice induced behavioral and physiological features characteristic of depression, including anhedonia and anxiety-like behaviors ( Kelly et al, 2016 ); (iii) FMT from normal mice to the Fmr1 KO mice (an animal model of Fragile X syndrome) ameliorated the autistic-like behaviors, especially memory deficits and social withdrawal ( Goo et al, 2020 ).…”

Section: Microbiota-targeted Strategies: From Phage Therapy To Pre/probiotic Approaches For Brain Pathologiesmentioning

confidence: 99%

Gut and Brain: Investigating Physiological and Pathological Interactions Between Microbiota and Brain to Gain New Therapeutic Avenues for Brain Diseases

Deidda

Biazzo

2021

Front. Neurosci.

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Brain physiological functions or pathological dysfunctions do surely depend on the activity of both neuronal and non-neuronal populations. Nevertheless, over the last decades, compelling and fast accumulating evidence showed that the brain is not alone. Indeed, the so-called “gut brain,” composed of the microbial populations living in the gut, forms a symbiotic superorganism weighing as the human brain and strongly communicating with the latter via the gut–brain axis. The gut brain does exert a control on brain (dys)functions and it will eventually become a promising valuable therapeutic target for a number of brain pathologies. In the present review, we will first describe the role of gut microbiota in normal brain physiology from neurodevelopment till adulthood, and thereafter we will discuss evidence from the literature showing how gut microbiota alterations are a signature in a number of brain pathologies ranging from neurodevelopmental to neurodegenerative disorders, and how pre/probiotic supplement interventions aimed to correct the altered dysbiosis in pathological conditions may represent a valuable future therapeutic strategy.

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“…Beneficial effects of FMT on ASD have also been described in murine models. Indeed, Goo et al observed that FMT from normal to Fmr1 KO mice significantly ameliorated autistic-like behaviors, especially cognitive dysfunctions and social withdrawal behaviors [71]. These results suggest that FMT may be a promising approach to treat ASD-related symptoms, but further investigations are needed in order to establish the optimal protocol and donor type.…”

Section: Gut Microbial-based Treatmentsmentioning

confidence: 99%

Gut Reactions: How Far Are We from Understanding and Manipulating the Microbiota Complexity and the Interaction with Its Host? Lessons from Autism Spectrum Disorder Studies

Lombardi

Troisi

2021

Nutrients

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Autism is a group of neurodevelopmental disorders, characterized by early onset difficulties in social communication and restricted, repetitive behaviors and interests. It is characterized by familial aggregation, suggesting that genetic factors play a role in disease development, in addition to developmentally early environmental factors. Here, we review the role of the gut microbiome in autism, as it has been characterized in case-control studies. We discuss how methodological differences may have led to inconclusive or contradictory results, even though a disproportion between harmful and beneficial bacteria is generally described in autism. Furthermore, we review the studies concerning the effects of gut microbial-based and dietary interventions on autism symptoms. Also, in this case, the results are not comparable due to the lack of standardized methods. Therefore, autism-specific microbiome signatures and, consequently, possible microbiome-oriented interventions are far from being recognized. We argue that a multi-omic longitudinal implementation may be useful to study metabolic changes connected to microbiome changes.

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The effect of fecal microbiota transplantation on autistic-like behaviors in Fmr1 KO mice

Cited by 34 publications

References 52 publications

Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

Gut and Brain: Investigating Physiological and Pathological Interactions Between Microbiota and Brain to Gain New Therapeutic Avenues for Brain Diseases

Gut Reactions: How Far Are We from Understanding and Manipulating the Microbiota Complexity and the Interaction with Its Host? Lessons from Autism Spectrum Disorder Studies

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