2015
DOI: 10.1111/anae.13274
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The effect of fibreoptic bronchoscopy in acute respiratory distress syndrome: experimental evidence from a lung model

Abstract: SummaryFlexible bronchoscopy is essential for appropriate care during mechanical ventilation, but can significantly affect mechanical ventilation of the lungs, particularly for patients with acute respiratory distress syndrome. We aimed to describe the consequences of bronchoscopy during lung‐protective ventilation in a bench study, and thereby to determine the optimal diameter of the bronchoscope for avoiding disruption of the protective‐ventilation strategy during the procedure. Immediately following the ins… Show more

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Cited by 15 publications
(19 citation statements)
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“…For example, we observed an increase of 10 cmH 2 O in total-PEEP and Pplat directly after insertion of the adult bronchoscopes into the 7.0mm tracheal tube. The increase in Pplat was almost identical to that of the PEEP under these conditions, as previously demonstrated [10]. In contrast, the paediatric and prototype bronchoscopes did not disrupt lung-protective ventilation; there was no clinically significant modification of pulmonary pressures.…”
Section: Resultssupporting
confidence: 82%
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“…For example, we observed an increase of 10 cmH 2 O in total-PEEP and Pplat directly after insertion of the adult bronchoscopes into the 7.0mm tracheal tube. The increase in Pplat was almost identical to that of the PEEP under these conditions, as previously demonstrated [10]. In contrast, the paediatric and prototype bronchoscopes did not disrupt lung-protective ventilation; there was no clinically significant modification of pulmonary pressures.…”
Section: Resultssupporting
confidence: 82%
“…Thus, it was important to confirm our experimental results using an animal model. We obtained similar results regardless of the model used; a substantial rise in total-PEEP with an adult bronchoscope, and no effect of bronchoscopy on the ventilatory MV (l.min -1 ) 10 20 30 Pressure (cmH2O) 10 20 30…”
Section: Discussionsupporting
confidence: 53%
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“…We would like to invite Nay et al. to explain in detail how they managed to simulate acute respiratory distress syndrome (ARDS) in the lung models used in their recent study of fibreoptic bronchoscopy , as to date, artificial models have been unable to replicate accurately the complex pathophysiology of the ARDS lung.…”
mentioning
confidence: 99%