The Effect of Fibrin Glue Application as a Sealant in Protecting Colon Anastomosis with Continues Suture Compared to Simple Interrupted Suture in Intraperitoneal Infection Condition Measured by Tissue Hydroxyproline Level (Wistar Rat Study)

Abstract

Background: Anastomotic leakage is a serious complication in gastrointestinal surgery, especially in peritonitis condition. Simple interrupted suture is the gold standard for intestinal anastomosis; however, it has a greater risk of contamination by peritoneal fluid. Fibrin glue has been used as a barrier to protect the intestinal anastomotic suture by increasing hydroxyproline levels. But its benefit in continuous suture is still debatable.Objective: To determine the effect of fibrin glue as a sealent in protecting colon anastomosis with continuous suture compared to simple interrupted suture in intraperitoneal infection conditions. Method:In this experimental study, the rats were divided into two groups: control group (Groups 1 and 2) and experimental group (Groups 3 and 4). Group 1 and 3 were performed by simple interrupted, while the others by continuous suture. Full-thickness incisions were made on the left colon and fibrin glue was applied over the sutures in experimental groups. The samples were taken on day 10.