The effect of fibromyalgia treatment on tinnitus

Çıl, Özge Çağlar; Zateri, Çoşkun; Güçlü, Oğuz; Oymak, Sibel; Tezcan, Erkan

doi:10.1016/j.amjoto.2020.102390

Cited by 12 publications

(6 citation statements)

References 22 publications

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“…Regarding the non-coincidental relationship between tinnitus and headache, as well as the probable common pathophysiological mechanisms linked by both entities, one should expect that, similarly to headache sufferers, tinnitus patients would have a vitamin D deficiency and may benefit from vitamin D supplementation [ 43 ]. Fibromyalgia is another pain condition associated with tinnitus and vitamin D, as the incidence of tinnitus is high in fibromyalgia patients, and fibromyalgia treatment improves tinnitus [ 44 ]. Interestingly, a recent review showed an association between vitamin D deficiency and fibromyalgia, so both entities may be related to vitamin D [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

The role of vitamin D in subjective tinnitus—A case-control study

et al. 2021

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Regarding the high prevalence of vitamin D (25(OH)D) deficiency in the population and its possible association with ear diseases, we aimed to investigate the 25(OH)Dserum level in patients with subjective, nonpulsating tinnitus and its effect on tinnitus severity. The study included 201 tinnitus patients and 99 controls. Patient clinical information, including tinnitus characteristics and severity according to Tinnitus Handicap Inventory (THI), loudness assessed by Visual Analogue Scale (VAS), audiometry, and the blood level of vitamin D, was recorded. The level of 25(OH)D in tinnitus patients was significantly decreased compared with the controls (19.86 ± 7.53 and 27.43 ± 8.85 ng/ml, respectively; P value < 0.0001). More patients in the tinnitus group were deficient in vitamin D, compared with the controls (50.7% vs. 22.2% respectively, p < 0.0001). Tinnitus patients with a lower serum level of 25(OH)D (≤15 ng/dl) were significantly younger, had a higher degree of tinnitus severity measured with THI and VAS scales, had higher triglyceride and TSH levels, and a lower HDL level compared with individuals who had higher 25(OH)D level (>15 ng/dl). There was a strong correlation between the 25(OH)D level and THI. Our findings suggest that a large proportion of tinnitus patients suffers from vitamin D deficiency and that the vitamin D level correlates with tinnitus impact. We recommend a vitamin D assessment for all tinnitus patients.

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Section: Resultsmentioning

confidence: 99%

The role of vitamin D in subjective tinnitus—A case-control study

et al. 2021

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“…Koca et al [ 16 ] found that FM patients had more otologic symptoms, including tinnitus and high level of oxidative stress. In another study, 74.3% of 101 FM patients had tinnitus despite having audiological test results in the normal range [ 7 ]. Herein, we confirm that fibromyalgia frequently accompanies tinnitus.…”

Section: Discussionmentioning

confidence: 99%

“…Some patients with FM have distressing neuropsychiatric symptoms and functional impairments [ 2 ]. It is well-known that otologic symptoms such as dizziness, hearing loss, and tinnitus also often associate with FM [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Tinnitus on Fibromyalgia

Chung

Jang

2021

J Rheum Dis

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Objective Fibromyalgia (FM) is a disorder characterized by chronic diffuse pain and enhanced pain response to stimuli and is caused by central sensitization Tinnitus also is related to central sensitization So we investigated the impact of tinnitus on FM Methods We included 22 FM patients with tinnitus and 25 FM patients without tinnitus We assessed a range of symptoms using the Widespread Pain Index; Symptom Severity Score scale; Visual Analogue Scale of pain; and the Korean versions of the Fibromyalgia Impact Questionnaire (FIQ), the Insomnia Severity Index, and the Short-form Health Survey (SF-36) Information about the severity of tinnitus in FM patients was evaluated using the Korean version of the Tinnitus Handicap Questionnaire (THQ-K) Results There were significant differences between the group that had mild tinnitus (THQ<38) and the group that had moderate-to-severe tinnitus (THQ≥38) for FIQ score (p=0025) and for the physical functioning (p=0003), social functioning (p=0035), and mental health (p=0017) components of the SF-36 Also, after dividing patients into 2 groups according to insomnia severity, significant differences were observed in FIQ score (p=0002) and in body pain (p=0001), general health (p=0008), vitality (p=0003), social functioning (p=0003), role limitation due to emotional condition (p=0001), and mental health (p<0001) components of the SF-36 Conclusion The FM patients with severe tinnitus had more functional impairments and lower quality of life than those with mild tinnitus Severe insomnia also was accompanied by worse health status and lower quality of life

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“…Fibromyalgia is characterized by widespread and chronic pain often accompanied by cognitive decline, anxiety, depression [1]. Currently, fibromyalgia treatment has shown limited clinical efficacy, partly due to the treatment is mostly a single analgesic treatment, which not only makes patients addicted to drugs but can also have adverse effects on their emotions and cognition [2][3][4]. Secondly, the impact of sensory processing disorders on patients may surpass the pain itself.…”

Section: Introductionmentioning

confidence: 99%

Abnormal characteristic static and dynamic functional network connectivity in fibromyalgia attention network

Wang,

Long,

Xie

et al. 2024

Preprint

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Background and purpose: Fibromyalgia is a commonly observed pain disorder linked to cognitive impairments, encompassing challenges in attention, memory, and executive processing. It has been proposed that fibromyalgia may be caused by changes in attention network. However, the neural network mechanisms underlying the relationship between the intrinsic fluctuations of functional connectivity in the brain network and clinical symptoms remain unclear. Methods: 46 fibromyalgia patients and 36 healthy controls underwent resting-state functional MRI (rs-fMRI). We employed static functional network connectivity (sFNC) and dynamic functional network connectivity (dFNC) to investigate the potential relationship between alterations in sensory integration and attention networks in fibromyalgia and clinical features. Results: Patients with fibromyalgia had reduced functional connectivity within the visual network (VIN), the auditory network (AUN), the default mode network (DMN), and the sensorimotor network (SMN). The decrease in functional connectivity in VIN and DMN was correlated with pain levels, while an increase in functional connectivity between SMN and the posterior dorsal attention network (DAN) was associated with symptoms. dFNC further observed that patients in state 4 show increased functional coupling between the ventral attention network (VAN) and both SMN and DMN, and the number of transitions between states positively correlated with pain levels. Conclusion: dFNC offered additional insights for understanding the pathophysiological mechanisms underlying fibromyalgia. Fibromyalgia patients exhibited increased in the attention network and reduced functionality in visual and auditory networks, which might contribute to the diminished attention towards external environmental stimuli and heightened sensitivity self-perception sensations observed in fibromyalgia.

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The effect of fibromyalgia treatment on tinnitus

Cited by 12 publications

References 22 publications

The role of vitamin D in subjective tinnitus—A case-control study

The role of vitamin D in subjective tinnitus—A case-control study

The Impact of Tinnitus on Fibromyalgia

Abnormal characteristic static and dynamic functional network connectivity in fibromyalgia attention network

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