The effect of fish bone bioactive peptides on the wound healing process: an in vitro study on keratinocytes

Iosăgeanu, Andreea; Oancea, Anca; Ilie, Daniela Elena; Anton, Elena Daniela; Crăciunescu, Oana

doi:10.25083/rbl/26.3/2692-2699

Cited by 7 publications

(2 citation statements)

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“…Oral administration of peptides extracted from various fish species and their by-products, such as collagen hydrolysates, demonstrates retention of moisture over the face along with enhanced viscoelastic properties and reduced sebum levels [145]. Enzymatic protein hydrolysates derived from the bones of silver carp and isolated peptides showed higher efficiency in stimulating metabolism of keratinocytes and wound healing activities, demonstrating the promising nature of bone peptides in care of wounds in the cutaneous region [146].…”

Section: Wound Healing Property Of Fish Waste Protein Hydrolysatesmentioning

confidence: 99%

Exploiting of Secondary Raw Materials from Fish Processing Industry as a Source of Bioactive Peptide-Rich Protein Hydrolysates

et al. 2021

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Developing peptide-based drugs are very promising to address many of the lifestyle mediated diseases which are prevalent in a major portion of the global population. As an alternative to synthetic peptide-based drugs, derived peptides from natural sources have gained a greater attention in the last two decades. Aquatic organisms including plants, fish and shellfish are known as a rich reservoir of parent protein molecules which can offer novel sequences of amino acids in peptides, having unique bio-functional properties upon hydrolyzing with proteases from different sources. However, rather than exploiting fish and shellfish stocks which are already under pressure due to overexploitation, the processing discards, regarded as secondary raw material, could be a potential choice for peptide based therapeutic development strategies. In this connection, we have attempted to review the scientific reports in this area of research that deal with some of the well-established bioactive properties, such as antihypertensive, anti-oxidative, anti-coagulative, antibacterial and anticarcinogenic properties, with reference to the type of enzymes, substrate used, degree of particular bio-functionality, mechanism, and wherever possible, the active amino acid sequences in peptides. Many of the studies have been conducted on hydrolysate (crude mixture of peptides) enriched with low molecular bioactive peptides. In vitro and in vivo experiments on the potency of bioactive peptides to modulate the human physiological functions beneficially have demonstrated that these peptides can be used in the prevention and treatment of non-communicable lifestyle mediated diseases. The information synthesized under this review could serve as a point of reference to drive further research on and development of functionally active therapeutic natural peptides. Availability of such scientific information is expected to open up new zones of investigation for adding value to underutilized secondary raw materials, which in turn paves the way for sustainability in fish processing. However, there are significant challenges ahead in exploring the fish waste as a source of bioactive peptides, as it demands more studies on mechanisms and structure–function relationship understanding as well as clearance from regulatory and statutory bodies before reaching the end user in the form of supplement or therapeutics.

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Section: Wound Healing Property Of Fish Waste Protein Hydrolysatesmentioning

confidence: 99%

Exploiting of Secondary Raw Materials from Fish Processing Industry as a Source of Bioactive Peptide-Rich Protein Hydrolysates

et al. 2021

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“…In practical applications, antioxidant peptides have demonstrated effectiveness in various contexts. For instance, they have shown promising results in reducing lipid oxidation in meat [23]. Additionally, incorporating antioxidant peptides into the formulation of flour for biscuit production has led to notable improvements in both the nutritional value and antioxidant capacity of the final product [24].…”

Section: Introductionmentioning

confidence: 99%

Valorization of Yellowfin Tuna Tails: An Approximation to Circular Bioeconomy

Sisa Allayca,

Martínez-Alvarez,

Gómez-Estaca

et al. 2024

Preprint

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This study investigates the valorization potential of yellowfin tuna tails for the production of high-value commercial products. Muscle and skins were firstly mechanically separated by using a specifically designed device. The muscle was then used as a nitrogen source for the growth of the proteolytic enzymes-producer Bacillus subtilis, whereas the skins were employed for gelatin extrac-tion. The proteases from Bacillus subtilis were partially purified and used to produce antioxidant peptides from gelatin obtained. The gelatin obtained formed a gel upon cooling, with gelling and melting temperatures at 16 ºC and 22 ºC, respectively, and Bloom Strength of ≈ 160. RSM was used to determine the optimal hydrolysis conditions to obtain the highest antioxidant activity (35.96%, measured as DPPH radical scavenging activity), which were 50°C / 6.5 IU of enzyme. The findings emphasize the importance of an integrated approach to maximize the value of tuna by-products, promoting sustainability in the frame of circular bioeconomy. Overall, these results contribute to the efficient utilization of tuna by-products, waste reduction, and enhance economic viability of the tuna industry.

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Extraction of Bioactive and Nutraceuticals from Marine Sources and Their Application

Rathod,

Reddy,

Čagalj

et al. 2024

Methods and Protocols in Food Science

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The effect of fish bone bioactive peptides on the wound healing process: an in vitro study on keratinocytes

Cited by 7 publications

References 0 publications

Exploiting of Secondary Raw Materials from Fish Processing Industry as a Source of Bioactive Peptide-Rich Protein Hydrolysates

Exploiting of Secondary Raw Materials from Fish Processing Industry as a Source of Bioactive Peptide-Rich Protein Hydrolysates

Valorization of Yellowfin Tuna Tails: An Approximation to Circular Bioeconomy

Extraction of Bioactive and Nutraceuticals from Marine Sources and Their Application

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