The effect of flight‐related behaviour on the risk of venous thrombosis after air travel

Schreijer, A. J. M.; Cannegieter, Suzanne C.; Doggen, Catharina Jacoba Maria; Rosendaal, Frits R.

doi:10.1111/j.1365-2141.2008.07489.x

Cited by 39 publications

(31 citation statements)

References 26 publications

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“…Virchows triad (1). Conditions with venous stasis such as immobilization, bed rest in hospital and physical restriction increase the risk of VTE (1–4). Muscle activity of the legs have important physiological effects such as decreased venous pressure, increased venous flow and edema prevention (5–7).…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular fitness in young males and risk of unprovoked venous thromboembolism in adulthood

Zöller

Sundquist

2016

Annals of Medicine

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Background Whether high cardiovascular fitness is associated with reduced risk of venous thromboembolism (VTE) is unknown. The present study aims to determine whether high cardiovascular fitness reduces the risk of VTE. Methods A Swedish cohort of male conscripts (n=773925) born in 1954–1970 with no history of previous VTE were followed from enlistment (1972–1990) until 2010. Data on cardiovascular fitness using a cycle ergonometric test (maximal aerobic workload in Watt [Wmax]) at conscription were linked with national hospital register data and the Multi-Generation Register. We identified all full-siblings and first-cousin pairs discordant for maximal aerobic workload. This co-relative design allows for adjustment for familial resemblance. Results In total, 3005 (0.39%) males were affected by VTE. Cardiovascular fitness estimated with Wmax was not associated with VTE risk when adjusted for body mass index (BMI). However, cardiovascular fitness estimated with Wmax/kg and adjusted for BMI was associated with reduced risk for VTE (Hazard ratio 0.81, 95% confidence interval 0.78–0.85 per standard deviation compared to mean Wmax/kg). The association was weaker over time and also when examining discordant first cousins and full-sibling pairs. Conclusions These results suggest that there is a relationship between cardiovascular fitness and weight that is important for future VTE risk.

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Section: Introductionmentioning

confidence: 99%

Cardiovascular fitness in young males and risk of unprovoked venous thromboembolism in adulthood

Zöller

Sundquist

2016

Annals of Medicine

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“…4 h, immobility during the fl ight and window seating (especially for obese persons) also increase the risk of VTE. 134 Especially tall or short passengers may have an increased risk. 130 There is no defi nitive evidence that dehydration, travel in economy class, and drinking alcoholic beverages on the fl ight are related to VTE risk.…”

Section: Risk Of Vtementioning

confidence: 99%

Prevention of VTE in Nonsurgical Patients

Falck‐Ytter

Francis

Johanson

et al. 2012

Chest

1,768

485

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“…[10][11][12] Muscle activity of the lower limbs promotes an acute and substantial decrease in venous pressure, elevation of venous flow, and prevention of edema. [13][14][15] It is, therefore, reasonable to assume that regular physical exercise protects against VTE.…”

Section: Introductionmentioning

confidence: 99%

Physical activity and risk of venous thromboembolism. The Tromso study

Borch¹,

Hansen-Krone²,

Brækkan³

et al. 2010

Haematologica

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BackgroundPrevious studies have shown differences in the impact of regular physical exercise on the risk of venous thromboembolism. The inconsistent findings may have depended on differences in study design and specific population cohorts (men only, women only and elderly). We conducted a prospective, population-based cohort to investigate the impact of regular physical exercise on the risk of venous thromboembolism. Design and MethodsRisk factors, including self-reported moderate intensity physical exercise during leisure time, were recorded for 26,490 people aged 25-97 years old, who participated in a population health survey, the Tromsø study, in 1994-95. Incident venous thromboembolic events were registered during the follow-up until September 1, 2007. ResultsThere were 460 validated incident venous thromboembolic events (1.61 per 1000 person-years) during a median of 12.5 years of follow-up. Age, body mass index, the proportion of daily smokers, total cholesterol, and serum triglycerides decreased (P<0.001), whereas high density cholesterol increased (P<0.001) across categories of more physical exercise. Regular physical exercise of moderate to high intensity during leisure time did not significantly affect the risk of venous thromboembolism in the general population. However, compared to inactivity, high amounts of physical exercise (≥3 hours/week) tended to increase the risk of provoked venous thromboembolism (multivariable hazard ratio, 1.30; 95% confidence interval, 0.84-2.0), and total venous thromboembolism in the elderly (multivariable hazard ratio, 1.33; 95% confidence interval, 0.80-2.21) and in the obese (multivariable hazard ratio, 1.49; 95% confidence interval, 0.63-3.50). Contrariwise, compared to inactivity, moderate physical activity (1.0-2.9 hours/week) was associated with a border-line significant decreased risk of venous thromboembolism among subjects under 60 years old (multivariable hazard ratio, 0.72; 95% confidence interval, 0.48-1.08) and subjects with a body mass index of less than 25 kg/m 2 (multivariable hazard ratio, 0.59; 95% confidence interval, 0.35-1.01). ConclusionsOur study showed that regular, moderate intensity physical exercise did not have a significant impact on the risk of venous thromboembolism in a general population. Future studies are required to assess the impact of regular physical exercise on venous thromboembolism risk in different population subgroups.Key words: venous thromboembolism, physical exercise, general population.Citation: Borch KH, Hansen-Krone I, Braekkan SK, Mathiesen EB, Njolstad I, Wilsgaard T, and Hansen J-B. Physical activity and risk of venous thromboembolism. The Tromsø study. Haematologica 2010;95(12):2088-2094. doi:10.3324/haematol.2009 © F e r r a t a S t o r t i F o u n d a t i o n

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The effect of flight‐related behaviour on the risk of venous thrombosis after air travel

Cited by 39 publications

References 26 publications

Cardiovascular fitness in young males and risk of unprovoked venous thromboembolism in adulthood

Cardiovascular fitness in young males and risk of unprovoked venous thromboembolism in adulthood

Prevention of VTE in Nonsurgical Patients

Physical activity and risk of venous thromboembolism. The Tromso study

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