The Effect of Fluoride and Strontium Application on Dentin: in Vivo and in Vitro Studies

Abstract

The effectiveness of topical 2% sodium fluoride applied with and without 10% strontium chloride pretreatment was compared in patients complaining of tooth hypersensitivity. In addition the radiopacity of 2% sodium fluoride and 25% strontium chloride treated dentin was studied in vitro. Reduction of sensitivity to cold and mechanical stimuli was evaluated during a period of 3 months by pain scoring in the exposed cervical dentin of homologous teeth on the two sides of the jaws. There was a significant decrease in the sensitivity of the exposed cervical dentin after treatment with sodium fluoride solution with or without pretreatment with strontium chloride solution. At the end of the experimental period the combined strontium and fluoride treatment was found to be more effective than that of fluoride alone in reducing sensitivity to cold. The increase in radiodensity of dentin samples immersed in strontium chloride was statistically significant, while there was no significant increase in density for the samples immersed in sodium fluoride solutions. A mineralization process is possibly the effective means by which fluoride or strontium diminishes sensitivity of dentin.

Strontium effects on root dentin tubule occlusion and nanomechanical properties

“…The mechanistic study design focused on elucidation of the interaction of strontium with dentin rather than the mechanism of action in fully formulated dentifrices. Strontium can substitute for Ca in hydroxyapatite to form Sr-Ca-hydroxyapatite [15,17,18,20]. This substitution can occur naturally in our daily acidic food consumption with the presence of strontium [19,42] or be induced in dental calcified tissues [15,21] or synthesized [20,43,44] in various strontium/calcium ratios.…”

“…Strontium can substitute for Ca in hydroxyapatite to form Sr-Ca-hydroxyapatite [15,17,18,20]. This substitution can occur naturally in our daily acidic food consumption with the presence of strontium [19,42] or be induced in dental calcified tissues [15,21] or synthesized [20,43,44] in various strontium/calcium ratios. Synthesized strontium apatite has been reported to demonstrate higher solubility than hydroxyapatite, and the solubility increases with greater strontium substitution (strontium ratio) [43,44].…”

“…Dedhiya et al confirmed a calcium strontium apatite Ca 6 Sr 4 (PO 4 ) 6 (OH) 2 is formed by the substitution of intracrystalline calcium in apatite by strontium [18]. Gedalia et al reported a significant increase of radiodensity after immersing sound and etched dentin in a 25% (w/w) strontium chloride solution for 24 h. Increased radiodensity was due to formation of Ca-Sr apatite [15]. Strontium has shown high affinity to dentin and apatite similar to other metals used for treating hypersensitivity such as zinc and tin.…”

“…Several chemicals such as fluoride help to deliver Ca and P into tubules [13], and strontium salts, either strontium chloride or strontium acetate, are found to be very effective in reducing dentin hypersensitivity [14]. Strontium also was reported to have the ability to improve radiodensity and if given prenatally it improves caries resistance [15,16].…”

Denti̇n Hassasi̇yeti̇ni̇n Tanisi, Etyoloji̇si̇ Ve Güncel Tedavi̇ Yaklaşimlari: Derleme

“…Birçok klinik çalışmada açığa çıkmış kök yü-zeylerinde, florlu diş macunları ve konsantre flor solüs-yonlarının dentin hassasiyeti tedavisinde etkili ajanlar olduğu gösterilmiştir. [32][33][34] NaF uygulamasından sonra fluorürün ağız sıvılarıyla hızlıca çözülerek kaybolması nedeniyle topikal uygulamanın sınırlı etkiye sahip olduğu için tek seferde dentin kanallarını tıkamaya yeterli olmadıkları için birkaç defa uygulanmaları gerektiği belirtilmiştir. 35 Florit cilasının etkili bir şekilde dentin hassasiyetini azalttığı ve bu etkinin 6 ay devam ettiğini bildirmiştir.…”