The effect of fluoride on the transformation of amorphous calcium phosphate into crystalline apatite

Hasvold, Ö.; Dahm, Sverre

doi:10.1007/bf02064119

Cited by 10 publications

(4 citation statements)

References 5 publications

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“…23 GA enhanced the formation of amorphous calcium-phosphate and inhibited the conversion rate to apatite like fluoride. 24 Additionally, the GA-HAP crystals were tested and directly observed using ATR-FTIR and fluorescence microscopy. The apatite structure and the PO 4 3À group were showed in the ATR-FTIR spectra.…”

Section: Discussionmentioning

confidence: 99%

Effects of gallic acid on the morphology and growth of hydroxyapatite crystals

Tang¹,

He²,

Cheng³

et al. 2015

Archives of Oral Biology

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Section: Discussionmentioning

confidence: 99%

Effects of gallic acid on the morphology and growth of hydroxyapatite crystals

Tang¹,

He²,

Cheng³

et al. 2015

Archives of Oral Biology

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“…Contamination by fluoride is also believed to be important. Fluoride has been found to reduce markedly and control dental caries, , enhance the rate of crystal growth, and act as a key factor in the transformation of minerals . It can easily substitute at the site of the hydroxide of HAp as the two ions have the same charge and similar radius.…”

Section: Problems Of the Conventional Methodsmentioning

confidence: 99%

“…Fluoride has been found to reduce markedly and control dental caries, 65,66 enhance the rate of crystal growth, 67 and act as a key factor in the transformation of minerals. 68 It can easily substitute at the site of the hydroxide of HAp as the two ions have the same charge and similar radius. Kamiya et al 69 reported that the substitution of hydroxide by fluoride significantly increased the stability of HAp, which was supported by Moreno et al, 70 who thought that it was due to surface effects.…”

Section: Contamination By Other Ionsmentioning

confidence: 99%

Calcium Phosphate Solubility: The Need for Re-Evaluation

Pan

Darvell

2008

Crystal Growth & Design

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The determination of the solubility of calcium phosphates by the conventional large excess of solid method has been demonstrated to be inappropriate. The problem lies in incongruent dissolution, leading to phase transformations, and lack of detailed solution equilibria: all calculations have been based on simplifications, which are only crudely approximate. The absolute solid-titration approach shows excellent reliability and reproducibility. Using solid titration, the true solubility isotherm of hydroxyapatite (HAp) has been found to lie substantially lower than previously reported. In addition, contrary to wide belief, dicalcium phosphate dihydrate (DCPD) is not the most stable phase below pH ∼4.2, where calcium-deficient HAp is less soluble. The misunderstanding here arises from the metastability of DCPD, which nucleates much more easily than HAp at low pH. Such results indicate that the Ca−P system is in need of complete reappraisal. The solid-titration method can be extended to other complex systems.

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“…The influence of fluoride on the crystallization pathways of HAP has been investigated. For example, it has been reported that fluoride can suppress the formation of octacalcium phosphate (OCP) by accelerating the hydrolysis OCP and promoted the formation of apatite nanorods directly on the amorphous surface. , However, fluoride can also increase the lifetime of ACP and retard the crystallization process. − Thus, despite intense investigation, the roles of fluoride in the formation and transformation of ACP remain elusive.…”

Section: Introductionmentioning

confidence: 99%

Mineralization Pathways of Amorphous Calcium Phosphate in the Presence of Fluoride

Song,

Cai,

et al. 2023

Crystal Growth & Design

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Amorphous calcium phosphate (ACP) has been widely reported as a metastable precursor during the mineralization of calcium phosphates in bone and enamel. Although the influence of fluoride on the crystallization of hydroxyapatite (HAP) has been extensively investigated, the mineralization pathways of ACP in the presence of fluoride are not fully understood. Here, using a combination of in situ monitoring and ex situ characterizations, we show that fluoride exhibits little effect on the formation and particle size of ACP nanospheres from a supersaturated calcium phosphate solution. However, the stability of ACP increases with increasing concentration of free fluoride ions in solution. We show that the aggregation of ACP nanospheres into larger spheres is an important step during ACP crystallization, which drives the nucleation of plate-like nanocrystals on the surface of ACP nanospheres and induces subsequent crystallization of ACP via a dissolutionrecrystallization pathway. In the presence of fluoride, the aggregation of ACP nanospheres and the nucleation of crystalline phases are retarded, thus stabilizing the amorphous phase. In addition, fluoride promotes the formation rod-like crystals on the surface of ACP nanospheres, which grow both outward from solution ions and inward from ACP nanospheres. These results significantly improve our understanding of the mineralization pathways of ACP and explain the inhibitory effect of fluoride during ACP crystallization.

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The effect of fluoride on the transformation of amorphous calcium phosphate into crystalline apatite

Cited by 10 publications

References 5 publications

Effects of gallic acid on the morphology and growth of hydroxyapatite crystals

Effects of gallic acid on the morphology and growth of hydroxyapatite crystals

Calcium Phosphate Solubility: The Need for Re-Evaluation

Mineralization Pathways of Amorphous Calcium Phosphate in the Presence of Fluoride

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